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In vitro method for safety testing of foot-and-mouth disease vaccines

  • E. C. Anderson (a1), P. B. Capstick (a1), G. N. Mowat (a1) and F. B. Leech (a2)

Summary

The susceptibility of the tissue culture system to small amounts of residual live virus was not influenced by the inactivated antigen present. The depth of inoculum over the cell sheet did not affect results. Negative cultures frequently gave positive first (but not second or later) sub-cultures.

Baby hamster kidney cells were always more sensitive than cattle tongues to infection with any of the strains used.

Confidence in the safety test depends on the number of vaccination doses used; the tissue culture test can be made much more reliable than the cattle test because it is not limited to the 15 ml. of inoculum that restricts the cattle test.

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Copyright

References

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Gard, S. (1960). Theoretical considerations in the inactivation of viruses by chemical means. Annals of the New York Academy of Science 83, 638.
Henderson, W. M. (1949). The quantitative study of foot-and-mouth disease. Agricultural Research Council Report Series no.8 London: Her Majesty's Stationery Office.
Henderson, W. M. (1952 a). A comparison of different routes of inoculation of cattle for detection of the virus of foot-and-mouth disease. Journal of Hygiene 50, 183.
Henderson, W. M. (1952 b). Significance of tests for non-infectivity of foot-and-mouth disease vaccines. Journal of Hygiene 50, 195.
Hyslop, N. & Skinner, H. H. (1964). A note on the interpretation of infectivity titres of foot-and-mouth disease virus based on cattle tongue titrations. Bulletin de l'Office International des Épizooties 61, 1091.
Macpherson, I. A. & Stoker, M. G. P. (1962). Polyoma transformation of hamster cell clones—an investigation of genetic factors affecting cell competence. Virology 16, 147.
Lewis, J. A. (1968). A program to fit constants to multiway tables of quantitative and quantal data. Applied Statistics 17, 33.
Peto, S. & Maidment, B. J. (1969). Tables of the upper limit to the estimate of the density of contaminating particles in a medium. Journal of Hygiene 67, 533.
Skinner, H. H. (1951). Propagation of strains of foot-and-mouth disease virus in unweaned white mice. Proceedings of the Royal Society of Medicine 44, 1041.

In vitro method for safety testing of foot-and-mouth disease vaccines

  • E. C. Anderson (a1), P. B. Capstick (a1), G. N. Mowat (a1) and F. B. Leech (a2)

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