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Impact of type 2 diabetes on manifestations and treatment outcome of pulmonary tuberculosis

  • C. S. WANG (a1) (a2), C. J. YANG (a2), H. C. CHEN (a1) (a2), S. H. CHUANG (a1), I. W. CHONG (a2), J. J. HWANG (a2) and M. S. HUANG (a2)...

Summary

Diabetes mellitus (DM) is a known risk factor for pulmonary tuberculosis (PTB). This study aimed to determine if type 2 DM alters manifestations and treatment outcome of PTB. Records of 217 consecutive culture-proven PTB patients were analysed retrospectively. The manifestations and treatment outcomes of 74 patients with type 2 DM (PTB-DM group) were compared to 143 patients without DM (PTB group). PTB-DM patients showed higher frequencies of fever, haemoptysis, positive acid-fast bacilli sputum smears, and consolidation, cavity, and lower lung field lesions on chest radiographs, and higher mortality rate. Furthermore, type 2 DM, age ⩾65 years, and extensive radiographic disease were factors independently associated with an unfavorable outcome. This study confirmed that clinical manifestations and chest radiographs of PTB patients associated with type 2 DM significantly depart from the typical presentation. Type 2 DM seems to have a negative effect on treatment outcome of PTB.

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Copyright

Corresponding author

*Author for correspondence: Dr M. S. Huang, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan. (Email: yyw0302@yahoo.com.tw)

References

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1.Dye, C, et al. Evolution of tuberculosis control and prospects for reducing tuberculosis incidence, prevalence, and deaths globally. Journal of the American Medical Association 2005; 293: 27672775.
2.Alisjahbana, B, et al. Diabetes mellitus is strongly associated with tuberculosis in Indonesia. International Journal of Tuberculosis and Lung Disease 2006; 10: 696700.
3.Mugusi, F, et al. Increased prevalence of diabetes mellitus in patients with pulmonary tuberculosis in Tanzania. Tubercle 1990; 71: 271276.
4.Kim, SJ, et al. Incidence of pulmonary tuberculosis among diabetics. Tubercle and Lung Disease 1995; 76: 529533.
5.Ponce-De-Leon, A, et al. Tuberculosis and diabetes in southern Mexico. Diabetes Care 2004; 27: 15841590.
6.Stevenson, CR, et al. Diabetes and the risk of tuberculosis: a neglected threat to public health? Chronic Illness 2007; 3: 228245.
7.Wild, S, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 10471053.
8.Perez-Guzman, C, et al. Atypical radiological images of pulmonary tuberculosis in 192 diabetic patients: a comparative study. International Journal of Tuberculosis and Lung Disease 2001; 5: 455461.
9.Perez-Guzman, C, et al. Progressive age-related changes in pulmonary tuberculosis images and the effect of diabetes. American Journal of Respiratory and Critical Care Medicine 2000; 162: 17381740.
10.Shaikh, MA, et al. Does diabetes alter the radiological presentation of pulmonary tuberculosis. Saudi Medical Journal 2003; 24: 278281.
11.Rieder, HL, et al. Surveillance of tuberculosis in Europe. Working Group of the World Health Organization (WHO) and the European Region of the International Union Against Tuberculosis and Lung Disease (IUATLD) for uniform reporting on tuberculosis cases. European Respiratory Journal 1996; 9: 10971104.
12.Tuddenham, WJ. Glossary of terms for thoracic radiology: recommendations of the Nomenclature Committee of the Fleischner Society. American Journal of Roentgenology 1984; 143: 509517.
13.WHO. Global tuberculosis control: surveillance, planning, financing. WHO report, 2006. Geneva, World Health Organization (WHO/HTM/TB/2006.362). (http://www.who.int/tb/publications/global_report/2006/pdf/full_report.pdf). Accessed 1 December 2007.
14.Restrepo, BI, et al. Type 2 diabetes and tuberculosis in a dynamic bi-national border population. Epidemiology and Infection 2007; 135: 483491.
15.Shetty, N, et al. An epidemiological evaluation of risk factors for tuberculosis in South India: a matched case control study. International Journal of Tuberculosis and Lung Disease 2006; 10: 8086.
16.Singla, R, et al. Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients. International Journal of Tuberculosis and Lung Disease 2006; 10: 7479.
17.Stevenson, CR, et al. Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health 2007; 7: 234.
18.Alisjahbana, B, et al. The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clinical Infectious Diseases 2007; 45: 428435.
19.Nissapatorn, V, et al. Tuberculosis in diabetic patients: a clinical perspective. Southeast Asian Journal of Tropical Medicine and Public Health 2005; 36: 213220.
20.Bacakoglu, F, et al. Pulmonary tuberculosis in patients with diabetes mellitus. Respiration 2001; 68: 595600.
21.al-Wabel, AH, et al. Symptomatology and chest roentgenographic changes of pulmonary tuberculosis among diabetics. East African Medical Journal 1997; 74: 6264.
22.Wang, JY, Lee, LN, Hsueh, PR. Factors changing the manifestation of pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease 2005; 9: 777783.
23.Hendy, M, Stableforth, D. The effect of established diabetes mellitus on the presentation of infiltrative pulmonary tuberculosis in the immigrant Asian community of an inner city area of the United Kingdom. British Journal of Diseases of the Chest 1983; 77: 8790.
24.Weaver, RA. Unusual radiographic presentation of pulmonary tuberculosis in diabetic patients. American Review of Respiratory Disease 1974; 109: 162163.
25.Koziel, H, Koziel, MJ. Pulmonary complications of diabetes mellitus. Pneumonia. Infectious Disease Clinics of North America 1995; 9: 6596.
26.Glass, EJ, et al. Impairment of monocyte ‘lectin-like’ receptor activity in type 1 (insulin-dependent) diabetic patients. Diabetologia 1987; 30: 228231.
27.Repine, JE, Clawson, CC, Goetz, FC. Bactericidal function of neutrophils from patients with acute bacterial infections and from diabetics. Journal of Infectious Diseases 1980; 142: 869875.
28.Nijland, HM, et al. Exposure to rifampicin is strongly reduced in patients with tuberculosis and type 2 diabetes. Clinical Infectious Diseases 2006; 43: 848854.
29.Gwilt, PR, Nahhas, RR, Tracewell, WG. The effects of diabetes mellitus on pharmacokinetics and pharmacodynamics in humans. Clinical Pharmacokinetics 1991; 20: 477490.
30.Weiner, M, et al. Association between acquired rifamycin resistance and the pharmacokinetics of rifabutin and isoniazid among patients with HIV and tuberculosis. Clinical Infectious Diseases 2005; 40: 14811491.
31.Bagdade, JD. Infection in diabetes, predisposing factors. Postgraduate Medicine 1976; 59: 160164.

Impact of type 2 diabetes on manifestations and treatment outcome of pulmonary tuberculosis

  • C. S. WANG (a1) (a2), C. J. YANG (a2), H. C. CHEN (a1) (a2), S. H. CHUANG (a1), I. W. CHONG (a2), J. J. HWANG (a2) and M. S. HUANG (a2)...

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