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Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)

  • H. E. Larson (a1), D. A. J. Tyrrell (a1), C. H. Bowker (a2), C. W. potter (a3) and G. C. Schild (a4)...

Summary

Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong/8/73. Preliminary experiments showed that the 30c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the ‘current’ 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but the vaccine prepared from the current strain gave more.

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Copyright

COPYRIGHT: © Cambridge University Press 1978

References

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  • Cited by 13

  • Access

Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)

  • H. E. Larson (a1), D. A. J. Tyrrell (a1), C. H. Bowker (a2), C. W. potter (a3) and G. C. Schild (a4)...

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