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Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)

  • H. E. Larson (a1), D. A. J. Tyrrell (a1), C. H. Bowker (a2), C. W. potter (a3) and G. C. Schild (a4)...

Summary

Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong/8/73. Preliminary experiments showed that the 30c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the ‘current’ 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but the vaccine prepared from the current strain gave more.

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References

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Aymard-Henry, M., Coleman, M. T., Dowdle, W. R., Laver, W. G., Schild, G. C. & Webster, R. G. (1973). Influenzavirus neuraminidase and neuraminidase-inhibition test procedures. Bulletin of the World Health Organization 48, 199.
Fazekas De St Groth, S. & Hannoun, C. (1973). Selection by immunological presence of dominant mutants of influenza virus A/Hong Kong/68. Comptes Rendus Hebdomadaires des Séances de l'Académie des Sciences, Paris (Section D) 276, 1917.
Hannoun, C. (1973). Progress in influenza vaccination. 1) A vaccine against future strains. Nouvelle Presse Medicale 2, 1199.
Hobson, D., Curry, R. L., Beare, A. S. & Ward-Gardener, A. (1972). The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B virus. Journal of Hygiene 70, 767.
Hoskins, T. W., Davies, J. R., Allchin, A., Miller, C. L. & Pollock, T. M. (1973). Controlled trial of inactivated vaccine containing the A/Hong Kong strain during an outbreak of influenza due to the A/England/42/72 strain. Lancet ii, 116.
Laver, W. G., Downie, J. C. & Webster, R. G. (1974). Studies on the antigenic variation in influenza virus. Evidence for multiple antigenic determinants on the haemagglutinin subunits of A/Hong Kong/68 and A/England/72 strains. Virology 59, 230.
Lecomte, J. & Tyrrell, D. A. J. (1976). Isolation of anti-haemagglutinin antibodies with an influenza A virus immunoadsorbent. Journal of Immunological Methods 13, 355.
Morris, C. A., Freestone, P. S., Stealey, V. M. & Oliver, P. R. (1975). Recombinant WRL 105 strain live attenuated influenza vaccine. Lancet ii, 196.
Mostow, S. R., Schoenbaum, S. C., Dowdle, W. R., Coleman, M. T. & Kaye, H. S. (1969). Studies with inactivated influenza vaccines purified by zonal centrifugation. 1. Adverse reactions and serological responses. Bulletin of the World Health Organization 41, 525.
Schild, G. C., Oxford, J. S., Dowdle, W. R., Coleman, M., Pereira, M. S. & Chakra-Verty, P. (1974). Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic ‘drift’ for the Hong Kong virus. Bulletin of the World Health Organization 51, 1.
Stiver, H. G., Graves, P., Eickhoff, T. C. & Meiklejohn, G. (1973). Efficacy of ‘Hong Kong’ vaccine in preventing England variant influenza in 1972. New England Journal of Medicine 289, 1267.
Stuart-Harris, C. H. & Schild, G. C. (1976). Influenza. The Viruses and the Disease. London, Arnold.
Tyrrell, D. A. J., Buckland, R., Rubenstein, D. & Sharpe, D. M. (1970). Vaccination against Hong Kong influenza in Britain. Journal of Hygiene 68, 359.
Virelizier, J. L., Postlethwaite, R., Schild, G. C. & Allison, A. C. (1974). Antibody responses to antigenic determinants of influenza virus haemagglutinin. 1. Thymus dependence of antibody formation and thymus independence of immunological memory. Journal of Experimental Medicine 140, 1559.
Westwood, M., Woodward, P. M. & Perkins, F. T. (1971). The British reference preparation for influenza virus haemagglutinin. Journal of Hygiene 69, 263.

Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)

  • H. E. Larson (a1), D. A. J. Tyrrell (a1), C. H. Bowker (a2), C. W. potter (a3) and G. C. Schild (a4)...

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