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High burden of RSV hospitalization in very young children: a data linkage study

  • N. HOMAIRA (a1), J.-L. OEI (a1) (a2), K-A. MALLITT (a1), M. E. ABDEL-LATIF (a3), L. HILDER (a4), B. BAJUK (a5), K. LUI (a1), M. FERSON (a6) (a7), A. NURKIC (a6), G. M. CHAMBERS (a4), W. RAWLINSON (a8) (a9) (a10), T. SNELLING (a11) (a12) (a13) and A. JAFFE (a1) (a14)...

Summary

Linked administrative population data were used to estimate the burden of childhood respiratory syncytial virus (RSV) hospitalization in an Australian cohort aged <5 years. RSV-coded hospitalizations data were extracted for all children aged <5 years born in New South Wales (NSW), Australia between 2001 and 2010. Incidence was calculated as the total number of new episodes of RSV hospitalization divided by the child-years at risk. Mean cost per episode of RSV hospitalization was estimated using public hospital cost weights. The cohort comprised of 870 314 children. The population-based incidence/1000 child-years of RSV hospitalization for children aged <5 years was 4·9 with a rate of 25·6 in children aged <3 months. The incidence of RSV hospitalization (per 1000 child-years) was 11·0 for Indigenous children, 81·5 for children with bronchopulmonary dysplasia (BPD), 10·2 for preterm children with gestational age (GA) 32–36 weeks, 27·0 for children with GA 28–31 weeks, 39·0 for children with GA <28 weeks and 6·7 for term children with low birthweight. RSV hospitalization was associated with an average annual cost of more than AUD 9 million in NSW. RSV was associated with a substantial burden of childhood hospitalization specifically in children aged <3 months and in Indigenous children and children born preterm or with BPD.

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Copyright

Corresponding author

*Author for correspondence: Dr N. Homaira, Discipline of Paediatrics, School of Women's and Children's Health, UNSW Australia, Level-3, Emergency Wing, Sydney Children's Hospital, Randwick, NSW 2031, Australia. (Email: n.homaira@unsw.edu.au)

References

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1. Leader, S, Kohlhase, K. Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999. Pediatric Infectious Disease Journal 2002; 21: 629632.
2. Hall, CB. Respiratory syncytial virus and parainfluenza virus. New England Journal of Medicine 2001; 344: 1917–28.
3. Yun, BY, et al. Viral etiology and epidemiology of acute lower respiratory tract infections in Korean children. Pediatric Infectious Disease Journal 1995; 14: 10541059.
4. Weissenbacher, M, et al. Etiologic and clinical evaluation of acute lower respiratory tract infections in young Argentinian children: an overview. Reviews of Infectious Diseases 1990; 12 (Suppl. 8): S889–98.
5. Simoes, EA. Respiratory syncytial virus infection. Lancet 1999; 354: 847852.
6. Iwane, MK, et al. Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004; 113: 17581764.
7. Shay, DK, et al. Bronchiolitis-associated hospitalizations among US children, 1980–1996. Journal of the American Medical Association 1999; 282: 14401446.
8. Holman, RC, et al. Infectious disease hospitalizations among American Indian and Alaska native infants. Pediatrics 2003; 111: E176182.
9. Holman, RC, et al. Respiratory syncytial virus hospitalizations among American Indian and Alaska Native infants and the general United States infant population. Pediatrics 2004; 114: e437444.
10. Madhi, SA, et al. Respiratory syncytial virus associated illness in high-risk children and national characterisation of the circulating virus genotype in South Africa. Journal of Clinical Virology 2003; 27: 180189.
11. Dede, A, et al. Respiratory syncytial virus infections in Central Australia. Journal of Paediatrics and Child Health 2010; 46: 3539.
12. Ranmuthugala, G, Brown, L, Lidbury, BA. Respiratory syncytial virus – the unrecognised cause of health and economic burden among young children in Australia. Communicable Disease Intelligence Quarterly Report 2011; 35: 177184.
13. Lister, S, Mcintyre, P, Menzies, R. The epidemiology of respiratory syncytial virus infections in NSW children, 1992–1997. New South Wales Public Health Bulletin 2000; 11: 119123.
14. De Silva, LM, Hanlon, MG. Respiratory syncytial virus: a report of a 5-year study at a children's hospital. Journal of Medical Virology 1986; 19: 299305.
15. Roche, P, Lambert, S, Spencer, J. Surveillance of viral pathogens in Australia: respiratory syncytial virus. Communicable Disease Intelligence Quarterly Report 2003; 27: 117122.
16. Torzillo, PJ, Chang, AB. Acute respiratory infections among Indigenous children. Medical Journal of Australia 2014; 200: 559560.
17. Australian Government. The health and welfare of Australia's Aboriginal and Torres Strait Islander people an overview. Australian Institute of Health and Welfare, 2011.
18. Schindeler, SK, et al. Evaluation of alternative respiratory syndromes for specific syndromic surveillance of influenza and respiratory syncytial virus: a time series analysis. BMC Infectious Diseases 2009; 9: 190.
19. Irvine, KA, Taylor, LK. The Centre for Health Record Linkage: fostering population health research in NSW. NSW Public Health Bulletin 2011; 22: 1718.
20. Bancalari, E, Claure, N, Sosenko, IR. Bronchopulmonary dysplasia:changes in pathogenesis, epidemiology and definition. Seminars in Neonatology 2003; 8: 6371.
21. Moutquin, JM. Classification and heterogeneity of preterm birth. An International Journal of Obstetrics & Gynaecology 2003; 110 (Suppl. 20): 3033.
22. NSW Government Ministry of Health. Costs of Care Standards 2009/10. 2011.
23. Karron, RA, et al. Severe respiratory syncytial virus disease in Alaska native children. RSV Alaska Study Group. Journal of Infectious Diseases 1999; 180: 4149.
24. Vos, T, et al. Burden of disease and injury in Aboriginal and Torres Strait Islander Peoples: the Indigenous health gap. International Journal of Epidemiology 2009; 38: 470477.
25. Hall, CB, et al. The burden of respiratory syncytial virus infection in young children. New England Journal of Medicine 2009; 360: 588598.
26. Khuri-Bulos, N, et al. Burden of respiratory syncytial virus in hospitalized infants and young children in Amman, Jordan. Scandinavian Journal of Infectious Diseases 2010; 42: 368374.
27. Nokes, DJ, et al. Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya. Clinical Infectious Diseases 2008; 46: 5057.
28. Henderson, J, et al. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatric Allergy and Immunology 2005; 16: 386392.
29. Sigurs, N, et al. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. American Journal of Respiratory and Critical Care Medicine 2000; 161: 15011507.
30. NSW Government. NSW Health Activity Based Management Portal. 2013–2014.
31. Pelletier, AJ, Mansbach, JM, Camargo, CA. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics 2006; 118: 24182423.
32. Resch, B. Burden of respiratory syncytial virus infection in young children. World Journal of Clinical Pediatrics 2012; 1: 812.
33. Mackman, RL, et al. Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. Journal of Medicinal Chemistry 2015; 58: 16301643.
34. DeVincenzo, JP, et al. Oral GS-5806 activity in a respiratory syncytial virus challenge study. New England Journal of Medicine 2014; 371: 711722.
35. Iwane, MK, et al. Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004; 113: 17581764.
36. Boyce, TG, et al. Rates of hospitalization for respiratory syncytial virus infection among children in medicaid. Journal of Pediatrics 2000; 137: 865870.
37. Groothuis, JR, Gutierrez, KM, Lauer, BA. Respiratory syncytial virus infection in children with bronchopulmonary dysplasia. Pediatrics 1988; 82: 199203.
38. Parnes, C, et al. Palivizumab prophylaxis of respiratory syncytial virus disease in 2000–2001: results from The Palivizumab Outcomes Registry. Pediatric Pulmonology 2003; 35: 484489.
39. Romero, JR. Palivizumab prophylaxis of respiratory syncytial virus disease from 1998 to 2002: results from four years of palivizumab usage. Pediatric Infectious Disease Journal 2003; 22: S4654.
40. Byington, CL, et al. Respiratory syncytial virus-associated mortality in hospitalized infants and young children. Pediatrics 2015; 135: e24–31.

Keywords

High burden of RSV hospitalization in very young children: a data linkage study

  • N. HOMAIRA (a1), J.-L. OEI (a1) (a2), K-A. MALLITT (a1), M. E. ABDEL-LATIF (a3), L. HILDER (a4), B. BAJUK (a5), K. LUI (a1), M. FERSON (a6) (a7), A. NURKIC (a6), G. M. CHAMBERS (a4), W. RAWLINSON (a8) (a9) (a10), T. SNELLING (a11) (a12) (a13) and A. JAFFE (a1) (a14)...

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