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The health status of a village population, 7 years after a major Q fever outbreak

  • G. MORROY (a1) (a2), W. VAN DER HOEK (a3), Z. D. NANVER (a1), P. M. SCHNEEBERGER (a4), C. P. BLEEKER-ROVERS (a5), J. VAN DER VELDEN (a2) and R. A. COUTINHO (a6)...

Summary

From 2007 to 2010, The Netherlands experienced a major Q fever outbreak with more than 4000 notifications. Previous studies suggested that Q fever patients could suffer long-term post-infection health impairments, especially fatigue. Our objective was to assess the Coxiella burnetii antibody prevalence and health status including fatigue, and assess their interrelationship in Herpen, a high-incidence village, 7 years after the outbreak began. In 2014, we invited all 2161 adult inhabitants for a questionnaire and a C. burnetii indirect fluorescence antibody assay (IFA). The health status was measured with the Nijmegen Clinical Screening Instrument (NCSI), consisting of eight subdomains including fatigue. Of the 70·1% (1517/2161) participants, 33·8% (513/1517) were IFA positive. Of 147 participants who were IFA positive in 2007, 25 (17%) seroreverted and were now IFA negative. Not positive IFA status, but age <50 years, smoking and co-morbidity, were independent risk factors for fatigue. Notified participants reported significantly more often fatigue (31/49, 63%) than non-notified IFA-positive participants (150/451, 33%). Although fatigue is a common sequel after acute Q fever, in this community-based survey we found no difference in fatigue levels between participants with and without C. burnetii antibodies.

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Copyright

Corresponding author

*Author for correspondence: G. Morroy, Medical Consultant in Communicable Disease Control, Department of Infectious Disease Control, Municipal Health Service Hart voor Brabant, Vogelstraat 2, 5212VL 's-Hertogenbosch, The Netherlands. (Email: g.morroy@ggdhvb.nl)

References

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The health status of a village population, 7 years after a major Q fever outbreak

  • G. MORROY (a1) (a2), W. VAN DER HOEK (a3), Z. D. NANVER (a1), P. M. SCHNEEBERGER (a4), C. P. BLEEKER-ROVERS (a5), J. VAN DER VELDEN (a2) and R. A. COUTINHO (a6)...

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