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Genetic marker studies on poliovirus type 1 strains from the Blackburn poliomyelitis outbreak in 1965

Published online by Cambridge University Press:  15 May 2009

Yvonne E. Cossart
Yvonne E. Cossart
Affiliation:
Virus Reference Laboratory, Central Public Health Laboratory, Colindale Avenue, London, N.W. 9
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Genetic marker tests were performed on 61 strains of poliovirus isolated during the Blackburn outbreak from cases or suspected cases and their contacts. The results were correlated with the epidemiological data and good agreement was found for the serological and dextran inhibition tests. The reproductive capacity temperature marker, however, showed inhibition at 39·8° C. of strains otherwise judged to be of naturally occurring type. These strains could be differentiated from those of vaccine origin because they grew readily at 39·2° C. This feature also distinguished the strains isolated in Blackburn from those obtained in the nearby town of Hyde in a simultaneous outbreak.

Dr J. Ardley, Medical Officer of Health, Blackburn, kindly provided a key which enabled the contacts of cases to be traced; and Dr L. Robertson, Public Health Laboratory, Preston, made available his extensive records as well as the many strains isolated in his laboratory.

Type
Research Article
Information
Journal of Hygiene , Volume 66 , Issue 4 , December 1968 , pp. 513 - 518
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Ardley, J. (1966). The health of Blackburn. Ann. Report on the Health Service for the Year 1965.Google Scholar
Cossart, Y. E. (1967 a). Genetic marker studies of poliomyelitis. I. Natural variation. J. Hyg., Camb. 65, 67.CrossRefGoogle Scholar
Cossart, Y. E. (1967 b). Genetic marker studies of poliomyelitis. II. Strains isolated from cases of poliomyelitis associated with the administration of live attenuated vaccine. J. Hyg., Camb. 65, 77.CrossRefGoogle ScholarPubMed
Robertson, L., Tobin, J. O'H., Ardley, J., Darley, A. S. & Cowburn, C. R. (1966). Laboratory findings in two outbreaks of poliomyelitis in the north-west of England in 1965. Proc. XIth European Symp. of Poliomyelitis & Allied Dis.,Rome, 1966.Google Scholar