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Evidence of increased clinical protection of an MF59-adjuvant influenza vaccine compared to a non-adjuvant vaccine among elderly residents of long-term care facilities in Italy

  • A. IOB (a1), G. BRIANTI (a2), E. ZAMPARO (a3) and T. GALLO (a4)

Abstract

We evaluated whether the increased immunogenicity provided by an MF59-adjuvant influenza vaccine translates into increased protection among the elderly. Residents of 25 long-term care facilities received either the adjuvant or a non-adjuvant vaccine. The odds ratios (OR) of influenza-like illness were calculated for non-adjuvant vs. adjuvant vaccine recipients, also stratifying for chronic cardiovascular, respiratory, and renal diseases. The risk was higher for the non-adjuvant vaccine recipients and highest for those with respiratory disease (OR 2·27, 95% CI 1·09–4·82) and cardiovascular disease (OR 1·88; 95% CI 1·31–2·72). In this study the MF59-adjuvant vaccine provided superior clinical protection among the elderly, especially those with chronic diseases.

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Copyright

Corresponding author

Azienda Servizi Sanitari no. 3, Piazza Baldissera 1,33030 Gemona del Friuli, UD, Italy. (Email: dip@ass3.sanita.fvg.it)

Evidence of increased clinical protection of an MF59-adjuvant influenza vaccine compared to a non-adjuvant vaccine among elderly residents of long-term care facilities in Italy

  • A. IOB (a1), G. BRIANTI (a2), E. ZAMPARO (a3) and T. GALLO (a4)

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