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The epidemiology and surveillance of visceral leishmaniasis in the Campania region of Italy. The value of zymodeme typing

  • L. Gradoni (a1), R. Pizzuti (a2), L. di Martino (a3), M. Gramiccia (a1), R. Pempinello (a4), G. B. Gaeta (a5), M. Ferrara (a6), S. Scotti (a6) and S. Altieri (a4)...

Summary

Although human visceral leishmaniasis (VL) is a notifiable disease in Italy, there is evidence that the actual number of cases is far higher than that notified. A programme for active surveillance of VL in the 14 Italian endemic regions was launched by the Istituto Superiore di Sanità. We report data collected during a 3-year period of active surveillance in Campania, a south Tyrrhenian region covering 4·5% of the Italian territory. Out of 120 clinically suspected cases referred to medical and diagnostic references centres, there were 52 confirmed VL cases (17·3/year), i.e. 10-fold more than previously notified. Most of the infection sites were in rural areas or peripheral districts of towns in hilly parts of Naples province. An epidemic cluster of 10 cases was identified in a microfocus of Caserta province. The biochemical analysis of 23 Leishmania stocks showed a zymodeme composition indicating Campania as an old and well-established focus of VL. The data obtained emphasize that the present notification system for VL in Italy is inadequate.

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Copyright

Corresponding author

*Dr L. Gradoni, Laboratorio di Parasitologia, Istituto Superiore di Sanità, Viale Regina Elena 299-00161 Roma, Italy.

References

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1.Gramiccia, M, Gradoni, L, Angelici, MC. Epidemiology of Mediterranean leishmaniasis caused by Leishmania infantum: isoenzyme and kDNA analysis for the identification of parasites from man, vectors and reservoirs. In: Hart, DT, ed. Leishmaniases. The current status and new strategies for control. NATO ASI ser. A. New York: Plenum Press, 1989; 2137.
2.Gramiccia, M, Gradoni, L, Troiani, M. HIV-Leishmania co-infections in Italy. Isoenzyme characterization of Leishmania causing visceral leishmaniasis in HIV patients. Trans R Soc Trop Med Hyg 1992; 86: 161–3.
3.Pozio, E, Gradoni, L, Gramiccia, M. La leishmaniose canine en Italie de 1910 à 1983. Ann Parasitol Hum Comp 1985; 60: 543–53.
4.Gradoni, L, Pozio, E, Gramiccia, M, Maroli, M, Bettini, S. Leishmaniasis in Tuscany (Italy). VII. Studies on the role of the black rat, Rattus rattus, in the epidemiology of visceral leishmaniasis. Trans R Soc Trop Med Hyg 1983; 77: 427–31.
5.Bettini, S, Gramiccia, M, Gradoni, L, Atzeni, MC. Leishmaniasis in Sardinia. II. Natural infection of Phlebotomus perniciosus, Newstead, 1911, by Leishmania infantum Nicolle, 1908, in the province of Cagliari. Trans R Soc Trop Med Hyg 1986; 80: 458–9.
6.Maroli, M, Gramiccia, M, Gradoni, L. Natural infection of Phlebotomus perfiliewi with Leishmania infantum in a cutaneous leishmaniasis focus of the Abruzzi region, Italy. Trans R Soc Trop Med Hyg 1987; 81: 596–8.
7.Bettini, S, Gramiccia, M, Gradoni, L, Pozio, E, Mugnai, S, Maroli, M. Leishmaniasis in Tuscany (Italy). VIII. Human population response to leishmanin in the focus of Monte Argentario (Grosseto) and epidemiological evaluation. Ann Parasitol Hum Comp 1983; 58: 539–47.
8.Gramiccia, M, Bettini, S, Gradoni, L et al. Leishmaniasis in Sardinia. 5. Leishmanin reaction in the human population of a focus of low endemicity of canine leishmaniasis. Trans R Soc Trop Med Hyg 1990; 84: 371–4.
9.Bettini, S, Maroli, M, Gradoni, L. Leishmaniasis in Tuscany (Italy). IV. An analysis of all recorded human cases. Trans R Soc Trop Hyg 1981; 75: 338–44.
10.Cardarelli, A. Nosografia della pseudoleucemia splenica (infettiva) dei bambini. Boll R Accad Med Chir Napoli (Naples) 1890; 2: 1744.
11.Pampiglione, S, Bettini, S. Bibliografia italiana delle leishmaniosi dalle origini al 1980. Ann 1st Super Sanità (Rome) 1981; 17: 11150.
12.Gradoni, L, Scalone, A, Gramiccia, M. Estimation of population risk of leishmanial infections in Italy. Trans R Soc Trop Med Hyg. Submitted.
13.Gradoni, L, Scalone, A, Gramiccia, M. HIV-Leishmania co-infections in Italy: serological data as an indication of the sequence of acquisition of the two infections. Trans R Soc Trop Med Hyg 1993; 87: 94–6.
14.Evans, DA. Leishmania. In: Taylor, AER, Baker, JR, eds. In vitro methods for parasite cultivation. London: Academic Press, 1987: 5275.
15.di Martino, L, Pettoello Mantovani, M, Gradoni, L, Gramiccia, M, Guandalini, S. Low dosage combination of meglumine antimoniate plus allopurinol as first choice treatment of infantile visceral leishmaniasis in Italy. Trans R Soc Trop Med Hyg 1990; 84: 534–5.
16.Davidson, RN, Croft, SL, Scott, A, Maini, M, Moody, AH, Bryceson, ADM. Liposomal amphotericin B in drug-resistant visceral leishmaniasis. Lancet 1991; 337: 1061–2.
17.Maroli, M, Bettini, S. Leishmaniasis in Tuscany (Italy): I. An investigation on phlebotomine sandflies in Grosseto Province. Trans R Soc Trop Med Hyg 1977; 71: 315–21.
18.Lysenko, AJ, Beljaev, AE. Quantitative approaches to epidemiology. In: Peters, W, Killick-Kendrick, R, eds. The leishmaniases in biology and medicine. Vol. I. Biology and epidemiology. London: Academic Press, 1987: 263–90.
19.Gradoni, L, Gramiccia, M, Mancianti, F, Pieri, S. Effectiveness of control measures against canine leishmaniasis in the isle of Elba, Italy. In: Hart, DT, ed. Leishmaniasis. The current status and new strategies for control. NATO ASI ser A, New York: Plenum Press, 1989; 71–6.
20.World Health Organization. Control of the leishmaniases. Tech Rep Ser No. 793, 1990: 158.
21.Sokal, JE. Measurement of delayed skin-test responses. N Eng J Med 1975; 293: 501–2.
22.Pampiglione, S, Manson-Bahr, PEC, La Placa, M, Borgatti, MA, Musumeci, S. Studies on Mediterranean leishmaniasis. 3. The leishmanin skin test in kala-azar. Trans R Soc Trop Med Hyg 1975; 69: 60–8.
23.Di Martino, L, Vajro, P, Nocerino, A, Scotti, S, Napolitano, G, Vegnente, A. Fulminant hepatitis in an Italian infant with visceral leishmaniasis. Trans R Soc Trop Med Hyg 1992; 86: 34.
24.Gramiccia, M, Gradoni, L, Di Martino, L, Romano, R, Ercolini, D. Two syntopic zymodemes of Leishmania infantum cause human and canine visceral leishmaniasis in the Naples area, Italy. Acta Trop 1992; 50: 357–9.
25.Jeannel, D, Tuppin, P, Brucker, G, Danis, M, Gentilini, M. Leishmaniasis in France. Lancet 1989; ii: 804.
26.Scarlata, F, Infantino, D, Giordano, S, Cascio, A. Monitoraggio della leishmaniosi viscerale in Sicilia nel biennio 1990–1991. Parasitologia 1992; 34 (suppl 1): 158–9.
27.Pampiglione, S, La, Placa M, Schlick, G. Studies on Mediterranean leishmaniasis. I. An outbreak of visceral leishmaniasis in northern Italy. Trans R Soc Trop Med Hyg 1974; 68: 349–59.

The epidemiology and surveillance of visceral leishmaniasis in the Campania region of Italy. The value of zymodeme typing

  • L. Gradoni (a1), R. Pizzuti (a2), L. di Martino (a3), M. Gramiccia (a1), R. Pempinello (a4), G. B. Gaeta (a5), M. Ferrara (a6), S. Scotti (a6) and S. Altieri (a4)...

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