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Epidemic mechanisms of Type A influenza

Published online by Cambridge University Press:  15 May 2009

R. E. Hope-simpson
R. E. Hope-simpson
Affiliation:
Epidemiological Research Unit, 86 Dyer Street, Cirencester, Gloucestershire, England
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Summary

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The antigenic varieties of influenza A virus isolated from 1968 to 1976 in a surveillance of a small, rather remote population were similar to those from England and Wales as a whole, despite frequent antigenic changes during the period. Household studies in the first two H3N2 influenza A epidemics found low attack rates within households, a high proportion (70%) of affected households with only one case of influenza, similar distributions of affected households in the two epidemics by the number of cases of influenza and similar distributions of the influenza cases by the day of their onset in the household outbreak. No serial interval could be demonstrated by cumulating household outbreaks. More than one minor variant was causing influenza contemporaneously in the same villages in several seasons, and different variants were on one occasion found on successive days in bedfellows. The regular occurrence of epidemics in winter was often accompanied by the disappearance of the epidemic variants and their replacement, after a virus-free interval, by new variants.

These epidemiological findings seem best interpreted on the following tentative hypothesis. Influenza A sufferers do not transmit the virus during their illness; instead it rapidly becomes latent in their tissues so that they become symptomless carrier-hosts and develop specific immunity. Next season an extraneous seasonally mediated stimulus reactivates the latent virus residues so that the carrier-host becomes briefly infectious, though symptomless. Antigenic drift occurs because particles reconstituted to be identical with the progenitor virus cannot escape the specific immunity it has provoked in the carrier host. He can shed only mutants also determined by the progenitor virus. From the assortment of mutants shed by the carrier-host, his non-immune companions select that (those) which is best fitted to survive, and it rapidly causes influenzal illness. Epidemics consist largely or entirely of such persons sick with influenza caused by reactivated virus caught from symptomless carrier-hosts.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 1 , August 1979 , pp. 11 - 26
Copyright
Copyright © Cambridge University Press 1979

References

Andrewes, C. H. (1951). The epidemiology of influenza in the light of the 1951 outbreak. Proceedings of the Royal Society of Medicine 44, 803.CrossRefGoogle ScholarPubMed
Andrewes, C. H. (1952). Prospects for prevention of influenza. Transactions & Studies, College of Physicians of Philadelphia 20, 1.Google Scholar
Andrewes, C. H. (1971). Influenza and other puzzles. Radovi Imunoloskog Savoda, Zagreb 8, 39.Google Scholar
Archetti, I. & Horsfall, F. L. JR. (1950). Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum. Journal of Experimental Medicine 92, 441.CrossRefGoogle ScholarPubMed
Burnet, F. M. (1945). The carrier state in influenza. Virus as Organism, p. 107. Cambridge, Massachusetts.Google Scholar
Fazekas De St Groth, S. & Hannoun, C. (1973). Selection of spontaneous mutants of influenza A virus (Hong Kong). Comptes rendu hebdomadaire des séances de l'académie des Sciences de Paris D 276, 1917.Google Scholar
Frolov, A. F., Shcherbinskaia, A. M., Bybalko, S. L., Gavrilov, S. V. & Iatel, T. P. (1978). Phenomenon of prolonged circulation of the influenza A0 virus in the body. My¯krobiolohichniyi zhurnal 40, 102.Google Scholar
Gavrilov, V. I., Asher, D. M., Vyalushkina, S. D., Ratushkina, L. S., Zmieva, R. G. & Tumyan, B. G. (1972). Persistent infection of continuous line of pig kidney cells with a variant of the WSN strain of influenza A0 virus (36405). Proceedings of the Society for Experimental Biology and Medicine 140, 109.CrossRefGoogle Scholar
Golubev, Von D. B., Paramonova, M. S., Medvedeva, M. N. & Poljakov YU, M. (1975). Influenza A2 neuraminidases and their changes during persistence of viruses in tissue cultures. Zeitschrift für gesamte Hygiene 21, 324.Google Scholar
Hope-simpson, R. E. (1948). The period of transmission in certain epidemic diseases. An observational method for its discovery. Lancet ii, 755.CrossRefGoogle Scholar
Hope-simpson, R. E. (1952). The infectiousness of communicable diseases. Lancet ii, 549.Google Scholar
Hope-simpson, R. E. (1970). First outbreak of HongKong influenza in a general practice population in Great Britain. A field and laboratory study. British Medical Journal iii, 74.CrossRefGoogle Scholar
Hope-simpson, R. E. (1979). The influence of season upon type A influenza. In The Impact of Weather and Climate on Animals and Man(Period 1973–1978) (ed. Solco, W.Tromp). London: Heyden. (In the Press.)Google Scholar
Hope-simpson, R. E. & Higgins, P. G. (1969). A respiratory virus study in Great Britain – review and evaluation. Progress in Medical Virology 11, 354.Google ScholarPubMed
Isaacs, A. (1951). The 1951 influenza viruses. Proceedings of the Royal Society of Medicine 44, 801.CrossRefGoogle ScholarPubMed
Langmuir, A. D. & Schoenbaum, S. C. (1976). The epidemiology of influenza. Hospital Practice 11, 49.Google Scholar
Marine, W. M., Mcgowan, J. E. & Thomas, J. E. (1976). Influenza detection: A prospective comparison of surveillance methods and analysis of isolates. American Journal of Epidemiology 104, 248.CrossRefGoogle ScholarPubMed
MenŠÍik, J., Pospisil, Z., Machatkova, M., Tumova, B., Franz, J. & Stumpa, A. (1976). Adaptation of human influenza A/Hong Kong/68 (H3N2) virus to colostrum-deprived, specific-pathogen-free piglets. Zentralblatt für Veterinärmedizin 23B, 638.CrossRefGoogle Scholar
National institutes of health (1973). Epidemiology of influenza - summary of influenza workshop: IV. Journal of Infectious Diseases 128, 361.CrossRefGoogle Scholar
Pereira, M. S. & Chakraverty, P. (1977). The laboratory surveillance of influenza epidemics in the United Kingdom, 1968–1976. Journal of Hygiene 79, 77.CrossRefGoogle ScholarPubMed
Petrescu, A., Bronitki, A., Teodoiu, O., Mihail, A., Popescu, A., Cojita, M. & Petrisor, L. (1976). Virological study of some influenza outbreaks in the period January–March, 1975. Virologie 27, 111.Google ScholarPubMed
Shadrin, A. S., Marinich, I. G. & Taros, L. YU. (1977). Experimental and epidemiological estimation of seasonal climate-geographical features of non-specific resistance of the organism to influenza. Journal of Hygiene Epidemiology Microbiology & Immunology 21, 155.Google Scholar
Wallace, G. W. (1977). Swine influenza and lungworms. Journal of Infectious Diseases 135, 490.CrossRefGoogle ScholarPubMed
Werner, J., Schudrowitz, C. & Kohler, H. (1975). Antigenic variation of neuraminidase of human type A influenza (H3N2) viruses isolated in Berlin (West). Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (Abt.1, Orig. A), 233, 440.Google ScholarPubMed