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Endotoxin removal from water using microporous polyethylene chopped fibres as a new adsorbent

  • Yosuke Sawada (a1), Reiko Fujii (a1), Ikuo Igami (a1), Atsushi Kawai (a1), Teruo Kamiki (a2) and Makoto Niwaf (a3)...

Summary

A new adsorbent, microporous polyethylene chopped fibre, was produced from a high density polyethylene. This can adsorb lipopolysaccharides (LPS) linearly up to 2 h, and showed the highest capacity to adsorb LPS when compared with two other polyethylene-based adsorbents and a polystyrene-based adsorbent. More than twice as much orange II and 4-nitroquinoline N oxide were adsorbed in the new adsorbent as was LPS. The adsorption isotherm of the new adsorbent for LPS was of Ln type, the correlation between adsorption and concentration of solute was proportional; whereas orange II and 4-nitroquinoline N oxide were of L type (greater adsorption than Ln type); tetrachloroethylene adsorption was of S type, less than Ln type. Adsorption of LPS to the new adsorbent increased when temperature rose, whereas adsorption of orange II and 4-nitroquinoline N oxide decreased. These data suggest that the binding of LPS to the new adsorbent is a hydrophobic interaction, whereas the binding of both orange II and 4-nitroquinoline N oxide is not. The new adsorbent has a greater potential for the removal of endotoxin from tap water than other commercially available adsorbents such as charcoal and Amberlite XAD-2.

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References

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Allingham, M. M., Giles, C. H. & Neustadter, E. L. (1954). Research on monolayers. Part 4. A study of dyeing processes by the use of the unimolecular film balance. Discussion of the Faraday Society 16, 92105.
Bene§, P. & Paulenova, M. (1973). Surface charge and adsorption properties of polyethylene in aqueous solutions of inorganic electrolytes. I. Streaming potential measurement. Kolloid-Zeitschrift und Zeitschrift für Poly mere 251, 766771.
Cradock, J. C., Guder, L. A., Francis, D. L., & Morgan, S. L. (1978). Reduction of pyrogens. Application of molecular filtration. Journal of Pharmacy and Pharmacology 30, 198199.
Ditter, B., Urbascheck, R. & Urbascheck, B. (1983). Ability of various adsorbents to bind endotoxins in vitro and to prevent orally induced endotoxemia in mice. Gastroenterology 84, 15471552.
Freundlich, H. (1926). Colloid and Capillary Chemistry. London: Methuen.
Fujita, Y. & Nakahara, C. (1982). Preparation and application of a new endotoxin determination kit, Pyrodick®, using a chromogenic substrate. In Endotoxins and Their Detection with the Limulus Amoebocyte Lysate Test (ed. Watson, S. W., Levin, J. and Novitsky, T. J.), pp. 173182. New York: A. R. Liss Inc.
Hannecart-Pokorni, E., Dekegel, D. & Dupuydt, F. (1973). Macromolecular structure of lipopolysaccharide from gram-negative bacteria. European Journal of Biochemistry 38, 613.
Harris, N. S. & Feinstein, R. (1976). In vitro process for detecting endotoxin in a biological fluid. U.S. Patent 3,944,391, March 16.
Hou, K., Gerba, C. P., Goyal, S. M. & Zerda, K. S. (1980). Capture of latex beads, bacteria, endotoxin and viruses by charge-modified filters. Applied and Environmental Microbiology 40, 892896.
Iwanaga, S., Morita, T., Harada, T., Nakamura, S., Niwa, M., Takada, K., Kimura, T. & Sakakibara, S. (1978). Chromogenic substrates for horseshoe crab clotting enzymes: its application for the assay of bacterial endotoxins. Haemostasis 7, 183188.
Kaden, H. (1975). The use of asbestos filter beds in the production of sterile and pyrogen-free solutions. Pharmazie 29, 752753.
Kamiki, T., Kawai, A., Igami, I. & Fujii, R. (1982). On a new medical sterile-water equipment utilized hollow fibres. Journal of Antibacterial and Antifungal Agents (Osaka) 10, 239247.
Minobe, S., Sato, T., Tosa, T. & Chibata, I. (1983). Characteristics of immobilized histamine for pyrogen adsorption. Journal of Chromatography 262, 193198.
Minobe, S., Watanabe, T., Sato, T., Tosa, T. & Chibata, I. (1982). Preparation of adsorbents for pyrogen adsorption. Journal of Chromatography 248, 401408.
Niwa, M., Milner, K. C., Ribi, E. & Rudbach, J. A. (1969). Alteration of physical, chemical and biological properties of endotoxin by treatment with mild alkali. Journal of Bacteriology 97, 10691077.
Niwa, M., Umeda, M. & Ohashi, K. (1982). Inactivation and immobilization of endotoxin. A novel endotoxin binding substance, polymyxin-Sepharose. Japanese Journal of Medical Science and Biology (Tokyo) 35, 114115.
Nolan, J. P., McDevitt, J. J. & Goldman, G. S. (1975). Endotoxin binding by charged and uncharged resins. Proceedings of the Society for Experimental Biology and Medicine 149, 766770.
Parkinson, G. (1983). Reverse osmosis: trying for wider applications. Chemical Engineering 90, 2631.
Pegues, A. S., Sofer, S. S., McCallum, R. E. & Hinshaw, L. B. (1979). The removal of 14C labelled endotoxin by activated charcoal. International Journal of Artificial Organs 2, 153158.
Ribi, E., Anacker, R. L., Brown, R., Haskins, W. T., Malmgren, B., Milner, K. C. & Rudbach, J. A. (1966). Reaction of endotoxin and surfactants. I. Physical and biological properties of endotoxin treated with sodium deoxycholate. Journal of Bacteriology 92, 14931509.
Sawada, Y., Fujii, R., Iqami, I., Kawai, A., Kamiki, T. & Miwa, M. (1986). The adsorption of endotoxin molecules in a microporous polyethylene hollow fibre membrane. Journal of Hygiene 97, 91102.
Schneider, H., Kresheck, G. C. & Scheraga, H. A. (1965). Thermodynamic parameters of hydrophobic bound formation in a model system. Journal of Physical Chemistry 69, 13101324.
Shindo, M., Yamamoto, T., Fukunaga, O. & Yamamori, H. (1983). Microporous polyethylene hollow fibers. U.S. Patent 4,401,567, Aug. 30.
Skelly, R. R., Munkenbeck, P. & Morrison, D. C. (1979). Stimulation of T-independent antibody responses by hapten-lipopolysaccharides without repeating polymeric structure. Infection and Immunity 23, 287293.
Sweadner, K. J., Forte, M. & Nelsen, L. L. (1977). Filtration removal of endotoxin (pyrogens) in solutionindiflerentstagesof aggregation. Applied and Environmental Microbiology 34, 382385.
Tsuji, K. & Harrison, S. J. (1979). Limulus amoebocyte lysate–a mean to monitor inactivation of lipopolysaccharide. In Biomedical Application of Horseshoe Crub (Limulidae) (ed. Cohen, E.), pp. 367378. New York: A. R. Liss Inc.

Endotoxin removal from water using microporous polyethylene chopped fibres as a new adsorbent

  • Yosuke Sawada (a1), Reiko Fujii (a1), Ikuo Igami (a1), Atsushi Kawai (a1), Teruo Kamiki (a2) and Makoto Niwaf (a3)...

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