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Effects of chloramphenicol on Chlamydia trachomatis infection in neonatal conjunctivitis and in McCoy cell cultures

Published online by Cambridge University Press:  25 March 2010

D. Hobson ,
D. Stefanidis ,
E. Rees  and
I. A. Tait
D. Hobson
Affiliation:
Department of Medical Microbiology, The University of Liverpool, Liverpool L69 3BX
D. Stefanidis
Affiliation:
Department of Medical Microbiology, The University of Liverpool, Liverpool L69 3BX
E. Rees
Affiliation:
Department of Venereology, Royal Liverpool Hospital, Liverpool L7 8XW
I. A. Tait
Affiliation:
Department of Venereology, Royal Liverpool Hospital, Liverpool L7 8XW
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Summary

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It was found that 26 of 127 infants with chlamydial conjunctivitis had previously received chloramphenicol eye drops. This treatment had delayed the onset and reduced the degree of oedema, congestion and discharge compared with infected infants with no ‘first-line’ chemotherapy, but eye swabs remained positive in 22 (85 %) of the chloramphenicol treated infants.

The problems of designing laboratory tests which might accurately forecast the clinical value, or lack of value of antibiotics in chlamydial infections were investigated. The minimum inhibitory concentration (MIC) of chloramphenicol, against Chlamydia trachomatis in McCoy cell cultures varied widely according to the antibiotic preparation used, the timing and duration of its exhibition in relation to the single step growth cycle of C. trachomatis, and, in particular, the method of examination of infected tissue cultures for residual chlamydial growth after incubation with chloramphenicol.

Type
Research Article
Information
Journal of Hygiene , Volume 89 , Issue 3 , December 1982 , pp. 457 - 466
Copyright
Copyright © Cambridge University Press 1982

References

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