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The development and use of a test to identify resistance to the anticoagulant difenacoum in the Norway rat (Rattus norvegicus)*

  • R. Redfern (a1) and J. E. Gill (a1)

Summary

Feeding tests were carried out in the laboratory to obtain basic data on the susceptibility of wild Norway rats to difenacoum. The results were used to derive a standard test procedure for the identification of difenacoum resistance in warfarin-susceptible and resistant rats. Details are given of tests on rats from suspected difenacoum-resistant infestations on farms.

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Copyright

References

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Boyle, C. M. (1960). Case of apparent resistance of Rattus norvegicus Berkenhout to anticoagulant poisons. Nature, London 188, 517.
Drummond, D. C. & Wilson, E. J. (1968). Laboratory investigations of resistance to warfarin of Rattus norvegicus Berk, in Montgomeryshire and Shropshire. Annals of Applied Biology 61, 303–12.
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Hadler, M. R., Redfern, R. & Rowe, F. P. (1975). Laboratory evaluation of difenacoum as a rodenticide. Journal of Hygiene 74, 441–8.
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Rennison, B. D. & Hadler, M. R. (1975). Field trials of difenacoum against warfarin-resistant infestations of Rattus norvegicus. Journal of Hygiene 74, 449–55.
Rowe, F. P. & Redfern, R. (1965). Toxicity tests on suspected warfarin-resistant house mice (Mus musculus L.). Journal of Hygiene 63, 417–25.
Rowe, F. P. & Redfern, R. (1968). Comparative toxicity of the two anticoagulants, coumatetralyl and warfarin to wild house mice (Mus musculus L.). Annals of Applied Biology 62, 355–61.
World Health Organization (1975). Instructions for determining the susceptibility or resistance of rodents to anticoagulant rodenticides. W.H.O./V.B.C./75.595.

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