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Conversion of Bordetella pertussis to Bordetella parapertussis

Published online by Cambridge University Press:  15 May 2009

Norichika H. Kumazawa  and
Masanosuke Yoshikawa
Norichika H. Kumazawa
Affiliation:
Department of Bacterial Infection, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
Masanosuke Yoshikawa
Affiliation:
Department of Bacterial Infection, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
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The epidemiological and drug susceptibility data on whooping cough suggested a possibility that Bordetella pertussis converts in some way to Bordetella parapertussis. To prove this, B. pertussis strain 75 was treated with N-methyl-N'-nitro-N-nitrosoguanidine and a mutant resistant to staphcillin V and eight mutants resistant to trimethoprim were isolated. The staphcillin V-resistant mutant of B. pertussis agreed with all of the criteria of B. parapertussis and the trimethoprimresistant mutants also agreed with many of these criteria. Thus, a hypothesis is presented that B. parapertussis is a mutant of B. pertussis which appeared in nature probably by a selective pressure of antibiotics.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 1 , August 1978 , pp. 15 - 23
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Bacon, M. F., Overend, W. G., Lloyd, P. H. & Peacocke, A. R. (1967). The isolation, composition and physicochomical properties of deoxyribonucleic acid from Bordetella pertussis. Archives of Biochemistry and Biophysics 118, 352–61.CrossRefGoogle ScholarPubMed
Buchanan, R. E. & Gibbons, N. E. (eds.) (1974). Bergey's Manual of Determinative Bacteriology, 8th ed.Baltimore: Williams & Wilkins.Google Scholar
Lacey, B. W. (1960). Antigenic modulation of Bordetella pertussis. Journal of Hygiene 58, 57–93.CrossRefGoogle ScholarPubMed
Lautrop, H. (1971). Epidemics of parapertussis. Lancet i, 1195–7.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin reagent. The Journal of Biological Chemistry 21, 363–8.Google Scholar
Marmur, J. (1961). A procedure for the isolation of deoxyribonucleic acid from micro-organisms. Journal of Molecular Biology 3, 208–18.CrossRefGoogle Scholar
Miyamoto, Y., Taxizawa, K., Sanetaka, T., Takahashi, T., Takamiya, A., Yamada, M., Nakase, Y., Watanabe, T., Hirose, M., Niwa, T., Fujiki, Y. & Aoki, Y. (1974). An epidemic survey and clinical examination of a regional outbreak of whooping cough. The Journal of the Japanese Association for Infectious Diseases 48, 179–91. (In Japanese.)Google Scholar
Nakase, Y., Takatsu, K. & Kasuga, T. (1969). Antigenic structure and phase variation in Bordetella pertussis. Japanese Journal of Microbiology 13, 283–91.CrossRefGoogle ScholarPubMed
Niwa, M. (1962). Histamine sensitizing factor of Bordetella pertussis. The Journal of Biochemistry 51, 222–91.CrossRefGoogle ScholarPubMed
Schildkraut, C. L., Marmur, J. & Doty, P. (1962). Determination of the base Composition of deoxyribonucleic acid from its buoyant density in CsCl. Journal of Molecular Biology 4, 430–43.CrossRefGoogle ScholarPubMed
Sekiya, K., Watanabe, M., Yamada, M. & Nakase, Y. (1975). Serotyping of recently isolated strains of Bordetella pertussis. Japanese Journal of Bacteriology 30, 507–13. (In Japanese.)Google Scholar
Stanbridge, T. N. & Preston, N. W. (1974). Variation of serotype in strains of Bordetella pertussis. Journal of Hygiene 73, 305–10.CrossRefGoogle ScholarPubMed
Watanabe, M., Sekiya, K., Nakase, Y. & Yamada, M. (1975). Drug susceptibility of Bordetella pertussis and Bordetella parapertussis. Japanese Journal of Bacteriology 30, 501–5. (In Japanese.)Google Scholar