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Comparison of different vaccines and induced immune response against Campylobacter jejuni colonization in the infant mouse

Published online by Cambridge University Press:  15 May 2009

Alash'le G. Abimiku ,
Jean M. Dolby  and
S. P. Borriello
Alash'le G. Abimiku
Affiliation:
Microbial Pathogenicity Research Group, Division of Communicable Diseases, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
Jean M. Dolby
Affiliation:
Microbial Pathogenicity Research Group, Division of Communicable Diseases, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
S. P. Borriello
Affiliation:
Microbial Pathogenicity Research Group, Division of Communicable Diseases, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
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Summary

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The degree of protection conferred by vaccinated dams on infant mice against colonization by Campylobacter jejuni depended on the bacterial strain, preparation, and route of administration of the vaccine. In some instances of homologous protection, serum bactericidal titres correlated well with protection. However, boiled C. jejuni vaccine, which was non-protective, also elicited a strong bactericidal antibody response. Conversely, bactericidal activity could not be demonstrated against strains capable of cross-protection. There was a good correlation between high campylobacter-specific IgG response and bactericidal activity.

Type
Research Article
Information
Epidemiology & Infection , Volume 102 , Issue 2 , April 1989 , pp. 271 - 280
Copyright
Copyright © Cambridge University Press 1989

References

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