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Comparison of antibody responses and virus shedding following administration of trivalent oral poliomyelitis vaccines prepared either in monkey kidney or human diploid cell substrates

Published online by Cambridge University Press:  15 May 2009

D. S. Freestone ,
A. Kelly ,
R. Ferris ,
R. L. L. Simmons ,
C. Bowkerj ,
E. Letley  and
C. Bye
D. S. Freestone
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
A. Kelly
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
R. Ferris
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
R. L. L. Simmons
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
C. Bowkerj
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
E. Letley
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
C. Bye
Affiliation:
Departments of Clinical Immunology and Chemotherapy and Viral Products Quality Control, The Weilcome Research Laboratories, Beckenham, Kent
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Summary

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Nineteen (22·9%) of 83 sera collected before vaccination from adult volunteers aged 21–64 years were without neutralizing antibody to poliomyeitis at levels of 0·15 i.u./ml for types I and II and 0·1 i.u./ml for type III. Some correlations were found between the history of previous vaccination and the presence of antibody but these were not well defined.

Vaccination with a single dose of trivalent oral polio vaccine elicited fourfold or greater antibody responses to one or more poliomyelitis types in 53 (63·9%) volunteers, the percentage antibody responses being inversely related to the titre of antibody present before vaccination. Types I, II or III poliomyelitis virus were recovered from 76·8 % of faecal samples collected 1 week after vaccination. The percentage recovery progressively declined thereafter until virus was recovered from 10·5 % of samples collected 6 weeks after vaccination.

Type for type, the titres and percentages of antibody responses and virus shedding in faeces were similar following trivalent oral poliomyelitis vaccines whether prepared in monkey kidney or human diploid cell substrates. Some change in reproductive capacity temperature (r.c.t./40) marker was found in faecal isolates from volunteers vaccinated with monkey kidney and human diploid grown vaccines but no change in ‘d’ marker was found.

Type
Research Article
Information
Journal of Hygiene , Volume 84 , Issue 1 , February 1980 , pp. 17 - 28
Copyright
Copyright © Cambridge University Press 1980

References

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