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A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

  • E. J. Stott (a1), E. J. Bell (a1), M. B. Eadie (a1), C. A. C. Ross (a1) and N. R. Grist (a1)...

Extract

Between October 1963 and April 1965, 113 children with respiratory disease and 113 children with diarrhoeal disease were matched for age and time of entry into hospital and studied by virus isolation and serological techniques.

Infections with respiratory syncytial (RS) virus, parainfluenza virus and herpes simplex virus respectively were found in 29, 11 and 12 children in the respiratory illness group but in only 1, 2 and 4 children in the diarrhoeal group. Rhinoviruses were isolated from 10 children in each group and in seven cases were associated with lower respiratory disease. Adenovirus infections were found in nine children with respiratory disease and eight with diarrhoea. Of the 40 enteroviruses isolated 16 were associated with respiratory disease and 24 with diarrhoea.

A poor or delayed serological response in children under 4 months with RS virus infection was observed. Addition of unheated rabbit serum increased the sensitivity of the neutralization test with RS virus.

These findings indicate that respiratory syncytial and parainfluenza virus infections were clearly associated with respiratory illness but the pathogenic role of the other viruses was not clear.

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References

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Beem, M., Wright, F. H., Hamre, D., Egerer, R. & Oehme, M. (1960). Association of the chimpanzee coryza agent with acute respiratory disease in children. New Engl. J. Med. 263, 523.
Bloom, H. H., Forsyth, B. R., Johnson, K. M. & Chanock, R. M. (1963). Relationship of rhinovirus infection to mild upper respiratory disease. J. Am. med. Ass. 186, 38.
Cate, T. R., Couch, R. B., Fleet, W. F., Griffith, W. R., Gerone, P. J. & Knight, V. (1965). Production of tracheobronchitis in volunteers with rhinovirus in a small-particle aerosol. Am. J. Epidem. 81, 95.
Chanock, R. M., Hyun, Wha Kim, Vargosko, A. J., Deleva, A., Johnson, K. M., Cumming, C. & Parrott, R. H. (1961). Respiratory syncytial virus. I. Virus recovery and other observations during 1960 outbreak of bronchiolitis, pneumonia and minor respiratory diseases in children. J. Am. med. Ass. 176, 647.
Chanock, R. M. & Parrott, R. H. (1965). Acute respiratory disease in infancy and childhood: present understanding and prospects for prevention. Pediatrics, Springfield 36, 21.
Clarke, S. K. R., Corner, B. D., Gambier, D. M., Macrae, J. & Peacock, D. B. (1964).Viruses associated with acute respiratory infections. Br. med. J. i, 1536.
Coates, H. V., Kendrick, L. & Chanock, R. M. (1963). Antigenic differences between two strains of respiratory syncytial virus. Proc. Soc. exp. Biol. Med. 112, 958.
Connelly, A. P. & Hamre, D. (1964). Virologic studies on acute respiratory disease in young adults. II. Characteristics and serologic studies of three new rhinoviruses. J. Lab. clin. Med. 63, 30.
Doggett, J. E. & Taylor-Robinson, D. (1965). Serological studies with respiratory syncytial virus. Arch. ges. Virusforsch. 15, 601.
Duncan, I. B. R. (1961). Biological and serological properties of Frater virus—a cytopathogenic agent associated with aseptic meningitis. Arch. ges. Virusforsch. 11, 248.
Duncan, I. B. R. & Bell, E. J. (1961). Human amnion tissue culture in the routine virus laboratory. Br. med. J. ii, 863.
Eadie, M. B., Stott, E. J. & Grist, N. R. (1966). Virological studies in chronic bronchitis.Br. med. J. ii, 671.
Feldman, H. A. & Wang, S. S. (1961). Sensitivity of various viruses to chloroform. Proc. Soc. exp. Biol. Med. 106, 736.
Gardner, P. S., Elderkin, F. M. & Wall, A. H. (1964). Serological study of respiratory syncytial virus infections in infancy and childhood. Br. med. J. ii, 1570.
Grist, N. R., Ross, C. A. C., Bell, E. J. & Stott, E. J. (1966). Diagnostic Methods in Clinical Virology. Oxford, Blackwell Scientific Publications.
Hamparian, V. V., Leagus, M. B., Hilleman, M. R. & Stokes, J. (1964). Epidemiologic investigations of rhinovirus infections. Proc. Soc. exp. Biol. Med. 117, 469.
Hamre, D., Connelly, A. P., Procknow, J. J. (1964). Virologic studies of acute respiratory disease in young adults. III. Some biologic and serologic characteristics of seventeen rhinovirus serotypes isolated October, 1960 to June, 1961. J. Lab. clin. Med. 64, 450.
Hayflick, L. & Moorhead, P. S. (1961). Serial cultivation of human diploid cell strains.Expl Cell Res. 25, 585.
Holzel, A., Parker, L., Patterson, W. H., Cartmel, D., White, L. L. R., Purdy, R., Thompson, K. M. & Tobin, J. O'H. (1965). Virus isolations from throats of children admitted to hospital with respiratory and other diseases, Manchester 1962–4. Br. med. J. i, 614.
Johnson, K. M. & Rosen, L. (1963). Characteristics of five newly recognized enteroviruses recovered from the human oropharynx. Am. J. Hyg. 77, 15.
Ketler, A., Hamparian, V. V. & Hilleman, M. R. (1962). Characterization and classification of Echo 28-rhinovirus-coryzavirus agents. Proc. Soc. exp. Biol. Med. 110, 821.
Lim, K. A. & Benyesh-Melnick, M. (1960). Typing of enteroviruses (Coxsackie and Echo) by combinations of antiserum pools. J. Immun. 84, 409.
Neva, F. A. & Weller, T. H. (1964). Rubella interferon and factors influencing the indirect neutralization test for rubella antibody. J. Immun. 93, 466.
Parkman, P. D., Mundon, F. K., McCown, J. M. & Buescher, E. L. (1964). Studies of rubella. II. Neutralization of virus. J. Immun. 93, 608.
Phillips, C. A., Melnick, J. L. & Grim, C. A. (1965). Characterization of three new rhinovirus serotypes. Proc. Soc. exp. Biol. Med. 119, 798.
Plotkin, S. A. (1964). Virologic assistance in the management of German measles in pregnancy. J. Am. med. Ass. 190, 265.
Portnoy, B., Eckert, H. L. & Salvatore, M. A. (1965). Rhinovirus infection in children with acute lower respiratory disease: evidence against etiological importance. Pediatrics, Springfield 35, 899.
Reilly, C. M., Hoch, S. M., Stokes, J., McClelland, L., Hamparian, V. V., Ketler, A. & Hilleman, M. R. (1962). Clinical and laboratory findings in cases of respiratory illness caused by coryzaviruses. Ann. intern Med. 57, 515.
Ross, C. A. C., Stott, E. J., McMichael, S. & Crowther, I. A. (1964). Problems of laboratory diagnosis of respiratory syncytial virus infection in childhood. Arch. ges. Virusforsch. 14, 553.
Sommerville, R. G. (1958). Enteroviruses and diarrhoea in young persons. Lancet ii, 1347.
Taylor-Robinson, D. & Tyrrell, D. A. J. (1962). Serotypes of viruses (rhinoviruses) isolated from common colds. Lancet i, 452.
Tyrrell, D. A. J. & Chanock, R. M. (1963). Rhinoviruses: a description. Science, N.Y. 141, 152.
Webb, P. A., Johnson, K. M. & Mufson, M. A. (1964). Description of two newly-recognized rhinoviruses of human origin. Proc. Soc. exp. Biol. Med. 116, 845.

A comparative virological study of children in hospital with respiratory and diarrhoeal illnesses

  • E. J. Stott (a1), E. J. Bell (a1), M. B. Eadie (a1), C. A. C. Ross (a1) and N. R. Grist (a1)...

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