Skip to main content Accessibility help
×
Home

The burden of rotavirus gastroenteritis in children presenting to a paediatric hospital

  • E. INGLIS (a1), A. KESSON (a2), A. T. NEWALL (a3), K. MACARTNEY (a4) and C. R. MacINTYRE (a3)...

Summary

The aim of this study was to determine the burden, management and outcomes of rotavirus infection in young children presenting to a tertiary paediatric hospital in Sydney, Australia. All laboratory-confirmed cases of rotavirus in children aged <5 years were identified and medical records reviewed. In 2004, 80 children aged <5 years presented to the hospital with rotavirus gastroenteritis confirmed by stool testing. Infants aged <24 months comprised 75% of cases, with more males than females affected. Most children (86%) acquired rotavirus infection in the community, with a mean length of hospital admission of 2·3 days. There were eight cases of nosocomial infection at a rate of 3/10 000 admissions. The rates of intravenous fluid management (46%) and antibiotic use (28%) were high, reflecting the severity of disease presenting in a hospital setting. These data will help inform the assessment of the recently introduced rotavirus vaccination programme in Australia.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The burden of rotavirus gastroenteritis in children presenting to a paediatric hospital
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The burden of rotavirus gastroenteritis in children presenting to a paediatric hospital
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The burden of rotavirus gastroenteritis in children presenting to a paediatric hospital
      Available formats
      ×

Copyright

Corresponding author

*Author for correspondence: Dr A. T. Newall, School of Public Health and Community Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia. (Email: a.newall@unsw.edu.au)

References

Hide All
1. Parashar, UD, et al. Global illness and deaths caused by rotavirus disease in children. Emerging Infectious Diseases 2003; 9: 565572.
2. Galati, JC, et al. The burden of rotavirus-related illness among young children on the Australian health care system. Australia & New Zealand Journal of Public Health 2006; 30: 416421.
3. Beers, MH, Berkow, R (eds) The Merck Manual of Diagnosis and Therapy, 17th edn. NJ: Merck Research Laboratories: Whitehouse Station, 1999.
4. Elliott, EJ, Backhouse, JA, Leach, JW. Pre-admission management of acute gastroenteritis. Journal of Paediatrics and Child Health 1996; 32: 1821.
5. Liddle, JLM, et al. Rotavirus gastroenteritis: impact on young children, their families and the health system. Medical Journal of Australia 1997; 167: 304307.
6. Velazquez, FR, et al. Rotavirus infections in infants as protection against subsequent infections. New England Journal of Medicine 1996; 335: 10221028.
7. Murphy, TV, et al. Intussusception among infants given an oral rotavirus vaccine. New England Journal of Medicine 2001; 344: 564752.
8. Ruiz-Palacios, GM, et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. New England Journal of Medicine 2006; 35: 1122.
9. Vesikari, T, et al. Safety and efficacy of a pentavalent human–bovine (WC3) reassortant rotavirus vaccine. New England Journal of Medicine 1996; 354: 2333.
10. Australian Government Department of Health and Ageing. The Australian Immunisation Handbook, 8th edn. Canberra, 2003.
11. National Center for Health Statistics. The International Classification of Diseases, 9th revision, clinical modification. Ann Arbor, MI: US National Center for Health Statistics, 1978.
12. Ferson, MJ. Hospitalisations for rotavirus gastroenteritis among children under five of age in New South Wales. Medical Journal of Australia 1996; 164: 273276.
13. Ardern-Holmes, SL, et al. Trends in hospitalization and mortality from rotavirus disease in New Zealand infants. Pediatric Infectious Diseases Journal 1999; 18: 614619.
14. Malek, MA, et al. Diarrhea- and rotavirus-associated hospitalizations among children less than 5 years of age: United States, 1997 and 2000. Pediatrics 2006; 117: 18871892.
15. Newall, AT, et al. Burden of severe rotavirus disease in Australia. Journal of Paediatrics and Child Health 2006; 42: 521.
16. Kirkwood, CN, et al. Report of the Australian Rotavirus Surveillance Program 2003–2004. Communicable Disease Intelligence 2004; 28: 481485.
17. Parashar, UD, et al. Rotavirus and severe childhood diarrhea. Emerging Infectious Diseases 2006; 12: 304306.
18. Jin, S, et al. Trends in hospitalizations for diarrhea in United States children from 1979 through 1992: estimates of the morbidity associated with rotavirus. Pediatric Infectious Diseases Journal 1996; 15: 397404.
19. Elliott, EJ, Dalby-Payne, JR. Acute infectious diarrhoea and dehydration in children. Medical Journal of Australia 2004; 181: 565570.
20. Gavin, N, Merrick, N, Davidson, B. Efficiacy of glucose-based oral rehydration therapy. Paediatrics 1996; 98: 4551.
21. Fonseca, BK, Holdgate, A, Craig, JC. Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Archives of Pediatrics & Adolescent Medicine 2004; 158: 483490.
22. NSW Health Department. Acute management of young children and infants with gastroenteritis. Clinical practice guidelines, 2002.
23. Rodriguez-Baez, N, et al. Astrovirus, adenovirus, and rotavirus in hospitalized children: prevalence and association with gastroenteritis. Journal of Pediatric Gastroenterology and Nutrition 2002; 35: 6468.
24. Harrington, M, Butler, K, Cafferkey, M. Rotavirus infection in hospitalised children: incidence and impact on healthcare resources. Irish Journal of Medical Science 2003; 172: 3336.
25. Gianino, P, et al. Incidence of nosocomial rotavirus infections, symptomatic and asymptomatic, in breast-fed and non-breast-fed infants. Journal of Hospital Infection 2002; 50: 1317.
26. Hsu, VP, et al. Use of active surveillance to validate international classification of diseases code estimates of rotavirus hospitalizations in children. Pediatrics 2005; 115: 7882.
27. Newall, AT, et al. The cost-effectiveness of rotavirus vaccination in Australia. Vaccine 2007; 25: 88518860.

Keywords

The burden of rotavirus gastroenteritis in children presenting to a paediatric hospital

  • E. INGLIS (a1), A. KESSON (a2), A. T. NEWALL (a3), K. MACARTNEY (a4) and C. R. MacINTYRE (a3)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed