Skip to main content Accessibility help
×
Home

Association between asymptomatic carriage and sporadic (endemic) meningococcal disease in an open community

  • M. E. VERDÚ (a1), P. COLL (a1) (a2), J. A. VÁZQUEZ (a3), F. MARCH (a1), D. FONTANALS (a4), S. BERRÓN (a3), I. PONS (a4), D. VAN ESSO (a5) and G. PRATS (a1) (a2)...

Abstract

We analysed a strain collection representative of the overall Neisseria meningitidis population circulating in an open community (46000 inhabitants, Spain) during an endemic period (30 isolates from patients and 191 from throat cultures of healthy individuals) by both phenotypic and molecular techniques. Almost all patient isolates were assigned to three hyper-virulent lineages (ET-5 complex, ET-37 complex and cluster A4) by both multilocus enzyme electrophoresis (MEE) and pulsed-field gel electrophoresis (PFGE). In contrast, MEE and PFGE assigned 20% and 15% respectively of carrier isolates to the hyper-virulent clones (4% for both methods together). There was also a higher correlation between PFGE and phenotypes associated with virulent clones. These notable differences between the two molecular methods were further observed in more than half the carrier isolates, suggesting that the associations between these strains were distorted by recombination events. However, almost one-third of total endemic strains from symptom-free carriers and almost all patient strains belonged to clones defined by MEE and PFGE, with no known epidemiological connection. These data indicate low transmission and a weak clonal structure for N. meningitidis.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Association between asymptomatic carriage and sporadic (endemic) meningococcal disease in an open community
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Association between asymptomatic carriage and sporadic (endemic) meningococcal disease in an open community
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Association between asymptomatic carriage and sporadic (endemic) meningococcal disease in an open community
      Available formats
      ×

Copyright

Corresponding author

Author for correspondence: Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Av. Sant Antoni Maria Claret, 167 08025 Barcelona, Spain.

Related content

Powered by UNSILO

Association between asymptomatic carriage and sporadic (endemic) meningococcal disease in an open community

  • M. E. VERDÚ (a1), P. COLL (a1) (a2), J. A. VÁZQUEZ (a3), F. MARCH (a1), D. FONTANALS (a4), S. BERRÓN (a3), I. PONS (a4), D. VAN ESSO (a5) and G. PRATS (a1) (a2)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.