Hostname: page-component-68945f75b7-z7ghp Total loading time: 0 Render date: 2024-08-05T16:11:08.684Z Has data issue: false hasContentIssue false

Antigenic analysis of prototype influenza A (H3N2) strains by the antiserum absorption method

Published online by Cambridge University Press:  15 May 2009

Gy. Tak´tsy
Affiliation:
Department of Virology, National Institute of Public Health, Budapest, Hungary
K. Barb
Affiliation:
Department of Virology, National Institute of Public Health, Budapest, Hungary
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Prototype strains of the influenza A (H3N2) virus can be arranged on a gradient showing the degree of the antigenic drift which the haemagglutinins of the strains have undergone. The demonstration of fine antigenic differences is based on an antiserum absorption test which allows a detailed antigenic analysis of strains. The gradient provides information on variation in strains occurring in different geographical areas and its use may be helpful in differentiating between introduced strains and locally developing variants.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1973

References

REFERENCES

Archetti, I. & Horsfall, F. L. Jr. (1950). Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum. Journal of Experimental Medicine 92, 441–62.CrossRefGoogle ScholarPubMed
Laver, W. G. & Webster, B. G. (1968). Selection of antigenic mutants of influenza viruses. Isolation and peptide mapping of their hemagglutinin proteins. Virology 34, 193202.CrossRefGoogle Scholar
Takátsy, Gy. (1955). The use of spiral loops in serological and virological micro-methods. Acta microbiologica. Academiae scientiarum hungaricae 3, 191202.Google Scholar
Takátsy, Gy. & Barb, K. (1958). Antigenic difference between Hungarian strains of the Asian influenza virus and the prototype strain. Virology 5, 398400.Google Scholar
Takátsy, Gy. & Fübész, J. (1954). The antigenic structure of influenza virus as studied by a simple immune serum absorption test. Acta microbiologica Academiae scientiarum hungaricae 2, 105–19.Google Scholar
Takátsy, Gy. & Fübész, J. (1957). On the antigenic variation of the influenza A virus. Archiv für die gesamte Virusforschung 7, 344–54.Google Scholar
Takátsy, Gy. & Hamae, M. (1955). Recent studies of the antigenic structure of influenza virus by the antibody absorption test. Acta microbiologica Academiae scientiarum hungaricae 3, 203–12.Google Scholar