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Antibody to streptococcal opacity factor in human sera

  • W. R. Maxted (a1), Jean P. Widdowson (a1) and Cherry A. M. Fraser (a1)

Summary

Two tests are described for detecting antibody to the type-specific opacity factor (OF) of group A streptococci. This antibody was detected among patients convalescent from streptococcal sore throat in two communities in which out-breaks due to opacity factor-producing strains of group A streptococci occurred.

In an outbreak due to streptococci of M-type 22 there was a close correspondence between the distribution of anti-OF and of bactericidal M-antibody for the type. In a smaller outbreak due to M-type 58 streptococci, however, M-antibody was detected more often than antibody of OF.

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Copyright

References

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Gooder, H. (1961). Association of a serum opacity reaction with serological type in Streptococcus pyogenes. Journal of General Microbiology 25, 347–52.
Krumweide, E. (1954). Studies on a lipoproteinase of group A streptococci. Journal of Experimental Medicine 100, 629–39.
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Maxted, W. R., Widdowson, Jean P., Fraser, Cherry M., Ball, Ly. C. & Bassett, D. C. J. (1973). The use of the serum opacity reaction in the typing of group A streptococci. Journal of Medical Microbiology (to be published).
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Widdowson, Jean P., Maxted, W. R., Grant, Doris L. & Pinney, Alison M. (1971). The relationship between M-antigen and opacity factor in group A streptococci. Journal of General Microbiology 65, 6980.
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