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Antibiotic therapy for acute Q fever in The Netherlands in 2007 and 2008 and its relation to hospitalization

  • F. DIJKSTRA (a1), J. RIPHAGEN-DALHUISEN (a1) (a2), N. WIJERS (a1), E. HAK (a2), M. A. B. VAN DER SANDE (a1) (a3), G. MORROY (a4), P. M. SCHNEEBERGER (a1) (a5), B. SCHIMMER (a1), D. W. NOTERMANS (a1) and W. VAN DER HOEK (a1)...

Summary

Data about the effectiveness of different antibiotic regimens for the treatment of acute Q fever from clinical studies is scarce. We analysed the antibiotic treatment regimens of acute Q fever patients in 2007 and 2008 in The Netherlands and assessed whether hospitalization after a minimum of 2 days antibiotic therapy was related to the initial antibiotic therapy. Clinical data on antibiotic treatment and risk factors of acute Q fever patients were obtained from general practitioner medical records and self-reported by patients. For the 438 study patients, doxycycline was the most commonly prescribed initial antibiotic in both study years. After adjustments for confounding factors, doxycycline (200 mg/day), moxifloxacin, as well as other possibly effective antibiotics [including other new fluoroquinolones and doxycycline (100 mg/day)] showed significant lower risks for hospitalization compared to β-lactam antibiotics and azithromycin (reference group), with the lowest risk for doxycycline (200 mg/day) (odds ratio 0·04, 95% confidence interval 0·01–0·22). These data support current guidelines that recommend doxycycline as the first choice antibiotic for treating acute Q fever.

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Copyright

Corresponding author

*Author for correspondence: Ms. F. Dijkstra, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, PO box 1 – pb 75, 3720 BA Bilthoven, The Netherlands. (Email: frederika.dijkstra@rivm.nl)

References

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Keywords

Antibiotic therapy for acute Q fever in The Netherlands in 2007 and 2008 and its relation to hospitalization

  • F. DIJKSTRA (a1), J. RIPHAGEN-DALHUISEN (a1) (a2), N. WIJERS (a1), E. HAK (a2), M. A. B. VAN DER SANDE (a1) (a3), G. MORROY (a4), P. M. SCHNEEBERGER (a1) (a5), B. SCHIMMER (a1), D. W. NOTERMANS (a1) and W. VAN DER HOEK (a1)...

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