Skip to main content Accessibility help
×
Home

The Active Immunization of Guinea-Pigs Passively Immunized with Homologous Antitoxic Serum

  • J. H. Mason (a1), Mary Robinson (a1) and P. Agerholm Christensen (a1)

Summary

Groups of guinea-pigs were passively immunized against diphtheria toxin with homologous antitoxic serum so that their sera contained, at the start of the experiment, 1·0, 0·1, 0·01 or 0·001 unit/ml, respectively. They were then actively immunized with one, or two spaced, injections of 0·1 Lf of A.D.F. Two control groups were included, one passively immunized only and the other actively immunized only.

Passively produced serum titres of 0·01 and 0·001 unit/ml. did not interfere with active immunization in any demonstrable way.

A titre of 0·1 unit/ml. did interfere with active immunization, markedly 4 weeks after the primary, slightly 2 weeks after the secondary, and markedly 14 weeks after the secondary, stimulus.

A titre of 1·0 unit/ml. interfered with active immunization, markedly 4 weeks after the primary, and 2 and 14 weeks after the secondary, stimulus. This titre, however, did not completely annul the effect of the primary stimulus. The highest observed serum titre was obtained at the 32nd, instead of at the 4th week, as in the guinea-pigs actively immunized only.

In large measure the results confirm those of Barr and her colleagues who found that, in human babies, an initial ‘passive’ titre of 0·04 unit/ml. serum did not interfere with active immunization, whereas a titre of 0·1 unit/ml, led to unsatisfactory immunization.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The Active Immunization of Guinea-Pigs Passively Immunized with Homologous Antitoxic Serum
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The Active Immunization of Guinea-Pigs Passively Immunized with Homologous Antitoxic Serum
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The Active Immunization of Guinea-Pigs Passively Immunized with Homologous Antitoxic Serum
      Available formats
      ×

Copyright

References

Hide All
Barr, M., Glenny, A. T. & Randall, K. J. (1949). Concentration of diphtheria antitoxin in cord blood and rate of loss in babies. Lancet, ii, 324–6.
Barr, M. (1950). A cord-blood survey of diphtheria immunity. Comparison of two populations. Lancet, i, 1110–12.
Barr, M., Glenny, A. T. & Randall, K. J. (1950). Diphtheria immunization in young babies. A study of some factors involved. Lancet, i, 610.
Barr, M., Glenny, A. T. & Parish, H. J. (1951). Diphtheria antitoxin in cord-blood. Survey of samples from 15 areas of British Isles. Lancet, i, 713–16.
Mason, J. H. (1950). Alkali-dissolved diphtheria toxoid-antitoxin floccules adsorbed on aluminium carriers. J. Hyg., Camb., 48, 418–30.

The Active Immunization of Guinea-Pigs Passively Immunized with Homologous Antitoxic Serum

  • J. H. Mason (a1), Mary Robinson (a1) and P. Agerholm Christensen (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.