Skip to main content Accessibility help

Role of CD46 Polymorphisms in the Occurrence of Disease in Young Chinese Men With Human Adenovirus Type 55 Infection

  • Qi Lv (a1) (a2), Hui Ding (a2), Zi-quan Liu (a1) (a2), Hong-wei Gao (a1) (a2), Bao-guo Yu (a1) (a2), Zhou-wei Wu (a1), Hao-jun Fan (a1) (a2) and Shi-ke Hou (a1) (a2)...



Human adenovirus type 55 (HAdV-55) has recently caused multiple outbreaks. This study examined polymorphisms in CD46 to determine their involvement in HAdV-55 infection.


A total of 214 study subjects infected with HAdV-55 were included in our study. The study subjects were divided into those with silent infections (n=91), minor infections (n=85), and severe infections (n=38). Ten single nucleotide polymorphisms (SNPs) from CD46 were examined.


Compared with the AA genotype, the TT genotype at rs2724385 (CD46, A/T) was associated with a protective effect against disease occurrence, with an odds ratio (95% confidence interval) of 0.20 (0.04-0.97) (P=0.038). There were no significant differences between the patients with minor and severe infection and those who had silent HAdV-55 infection in the other CD46 SNPs. We next compared the polymorphisms of these genes according to disease severity in HAdV-55-infected patients with clinical symptoms. The results showed that there were no significant differences between minor infections and severe infections.


Our results suggested that the CD46 SNP at rs2724385 is associated with the occurrence of disease in HAdV-55-infected patients. A much larger number of samples is required to understand the role of CD46 polymorphisms in the occurrence and progression of infection by HAdV-55. (Disaster Med Public Health Preparedness. 2018;12:427–430)


Corresponding author

Correspondence and reprint requests to Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistic University of Chinese People’s Armed Police Force (PAP), Chenglin Road 220, Hedong District, Tianjin, 300162 (e-mail: [Hao-jun Fan]; [Shi-ke Hou]).


Hide All
1. Lenaerts, L, De Clercq, E, Naesens, L. Clinical features and treatment of adenovirus infections. Rev Med Virol. 2008;18(6):357-374.
2. Seto, D, Chodosh, J, Brister, JR, et al. Using the whole-genome sequence to characterize and name human adenoviruses. J Virol. 2011;85(11):5701-5702.
3. Hierholzer, JC, Pumarola, A, Rodriguez-Torres, A, et al. Occurrence of respiratory illness due to an atypical strain of adenovirus type 11 during a large outbreak in Spanish military recruits. Am J Epidemiol. 1974;99:434-442.
4. Chmielewicz, B, Benzler, J, Pauli, G, et al. Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey. J Med Virol. 2005;77(2):232-237.
5. Walsh, MP, Seto, J, Jones, MS, et al. Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen. J Clin Microbiol. 2010;48(3):991-993.
6. Zhu, Z, Zhang, Y, Xu, S, et al. Outbreak of acute respiratory disease in China caused by B2 species of adenovirus type 11. J Clin Microbiol. 2009;47(3):697-703.
7. Gu, L, Liu, Z, Li, X, et al. Severe community-acquired pneumonia caused by adenovirus type 11 in immunocompetent adults in Beijing. J Clin Virol. 2012;54(4):295-301.
8. Chen, WW, Nie, WM, Xu, W, et al. Cross-sectional study of the relationship of peripheral blood cell profiles with severity of infection by adenovirus type 55. BMC Infect Dis. 2014;14(1):147.
9. Xie, YX, Tu, B, Chen, WW, et al. Clinical characteristics of 80 hospitalized cases of human adenovirus type 55 infection. Infect Dis Info. 2013;26:45-47. Chinese.
10. Chen, RF, Lee, CY. Adenoviruses types, cell receptors and local innate cytokines in adenovirus infection. Int Rev Immunol. 2014;33(1):45-53.
11. Fleischli, C, Sirena, D, Lesage, G, et al. Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor. J Gen Virol. 2007;88(11):2925-2934.
12. Rowe, W, Huebner, R, Gilmore, L, et al. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med. 1953;84(3):570-573.
13. Horwitz, MS. Adenoviruses. Field Virol. 2001;2:2149-2171.
14. Hong, JY, Lee, HJ, Piedra, PA, et al. Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis. Clin Infect Dis. 2001;32(10):1423-1429.
15. Bergelson, JM, Cunningham, JA, Droguett, G, et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 1997;275(5304):1320-1323.
16. Bewley, MC, Springer, K, Zhang, YB, et al. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science. 1999;286(5444):1579-1583.
17. Seya, T, Hirano, A, Matsumoto, M, et al. Human membrane cofactor protein (MCP, CD46): multiple isoforms and functions. Int J Biochem Cell Biol. 1999;31(11):1255-1260.
18. Sirena, D, Lilienfeld, B, Eisenhut, M, et al. The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. J Virol. 2004;78(9):4454-4462.



Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed