Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-25T03:55:20.567Z Has data issue: false hasContentIssue false

Body Mass Index as a Predictor of Symptom Duration in COVID-19 Outpatients

Published online by Cambridge University Press:  04 August 2022

Parnian Jabbari
Affiliation:
Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Nazanin Taraghikhah
Affiliation:
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Forouq Jabbari
Affiliation:
Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
Saied Ebrahimi
Affiliation:
Research Department of Rajaei Heart Center, Iran University of Medical Sciences, Tehran, Iran
Nima Rezaei*
Affiliation:
Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
*
Corresponding author: Nima Rezaei, Email: rezaei_nima@tums.ac.ir, rezaei_nima@yahoo.com

Abstract

Background:

Obesity is a risk factor for various diseases and can affect the disease course. Studies have shown detrimental effects of obesity on patients affected with SARS-CoV-2 including increased hospitalization and more severe disease. This study aims to investigate the effects of obesity on symptom duration in patients with COVID-19, and also explore the possibility of using BMI as a predictor of symptom duration in outpatient settings.

Methods:

Patients diagnosed with COVID-19 between June and October 2020, who had no other comorbidities, and were planned to receive treatment in the outpatient setting were enrolled in the study. Duration of the symptoms was determined based on participants’ self-report of their symptoms. Linear regression was used to create predictive models based on participants’ BMI, age, sex, disease presentation, and their self-reported symptom duration.

Results:

A total of 210 patients were included in the final analysis. Patients with higher BMI had significantly longer symptom duration. Linear regression models showed highest correlation between BMI and symptom duration compared to other covariates.

Conclusion:

Low error in predictions and high coverage of data variability showed BMI can be used as a predictive factor for symptom duration in COVID-19 patients treated in outpatient settings.

Type
Original Research
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of Society for Disaster Medicine and Public Health, Inc.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Grant, MC, Geoghegan, L, Arbyn, M, et al. The prevalence of symptoms in 24410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): a systematic review and meta-analysis of 148 studies from 9 countries. PloS One. 2020;15(6):e0234765. doi: 10.1371/journal.pone.0234765 CrossRefGoogle Scholar
Pathak, SK, Pandey, S, Pandey, A, et al. Focus on uncommon symptoms of COVID-19: potential reason for spread of infection. Diabetes Metab Syndr. 2020;14(6):1873-1874. doi: 10.1016/j.dsx.2020.09.017 CrossRefGoogle ScholarPubMed
Callender, LA, Curran, M, Bates, SM, et al. The impact of pre-existing comorbidities and therapeutic interventions on COVID-19. Front Immunol. 2020;11:1991. doi: 10.3389/fimmu.2020.01991 CrossRefGoogle ScholarPubMed
Sanyaolu, A, Okorie, C, Marinkovic, A, et al. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med. 2020;2(8):1069-1076. doi: 10.1007/s42399-020-00363-4 CrossRefGoogle ScholarPubMed
R Core Team (2020) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.r-project.org/.Google Scholar
Pi-Sunyer, X. The medical risks of obesity. Postgrad Med. 2009;121(6):21-33. doi: 10.3810/pgm.2009.11.2074 CrossRefGoogle ScholarPubMed
Zhang, X, Lewis, AM, Moley, JR, Brestoff, JR. A systematic review and meta-analysis of obesity and COVID-19 outcomes. Sci Rep. 2021 Mar 30;11(1):7193. doi: 10.1038/s41598-021-86694-1 CrossRefGoogle ScholarPubMed
Lighter, J, Phillips, M, Hochman, S, et al. Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission. Clin Infect Dis. 2020;71(15):896-897. doi: 10.1093/cid/ciaa415 CrossRefGoogle ScholarPubMed
Bhasin, A, Nam, H, Yeh, C, et al. Is BMI higher in younger patients with COVID-19? Association between BMI and COVID-19 hospitalization by age. Obesity (Silver Spring). 2020;28(10):1811-1814. doi: 10.1002/oby.22947 CrossRefGoogle ScholarPubMed
Pettit, NN, MacKenzie, EL, Ridgway, JP, et al. Obesity is associated with increased risk for mortality among hospitalized patients with COVID-19. Obesity (Silver Spring). 2020;28(10):1806-1810. doi: 10.1002/oby.22941 CrossRefGoogle ScholarPubMed
Ong, SWX, Young, BE, Leo, Y-S, Lye, DC. Association of higher body mass index with severe coronavirus disease 2019 (COVID-19) in younger patients. Clin Infect Dis. 2020;71(16):2300-2302. doi: 10.1093/cid/ciaa548 CrossRefGoogle ScholarPubMed
Tenforde, MW, Kim, SS, Lindsell, CJ, et al. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network—United States, March–June 2020. MMWR. 2020;69(30):993-998. doi: 10.15585/mmwr.mm6930e1 Google Scholar
O’Keefe, JB, Tong, DC, O’Keefe, GAD. Symptom course in COVID-19 outpatients. medRxiv. 2020.Google Scholar
Bramante, CT, Buse, J, Tamaritz, L, et al. Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity. J Med Virol. 2021;93(7):4273-4279. doi: 0.1002/jmv.26873 CrossRefGoogle ScholarPubMed
Lange, SJ, Kompaniyets, L, Freedman, DS, et al. Longitudinal trends in Body Mass Index before and during the COVID-19 pandemic among persons aged 2–19 Years — United States, 2018–2020. MMWR. 2021;70(37):1278-1283. doi: 10.15585/mmwr.mm7037a3 Google ScholarPubMed