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Role of CD46 Polymorphisms in the Occurrence of Disease in Young Chinese Men With Human Adenovirus Type 55 Infection

Published online by Cambridge University Press:  20 September 2016

Qi Lv
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Hui Ding
Affiliation:
Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Zi-quan Liu
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Hong-wei Gao
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Bao-guo Yu
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Zhou-wei Wu
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China
Hao-jun Fan
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Shi-ke Hou
Affiliation:
Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of the Chinese People’s Armed Police Force (PAP), Tianjin, China Key Laboratory of Emergency and Disaster Medicine in the Chinese People’s Liberation Army (PLA), Tianjin, China.
Corresponding

Abstract

Objective

Human adenovirus type 55 (HAdV-55) has recently caused multiple outbreaks. This study examined polymorphisms in CD46 to determine their involvement in HAdV-55 infection.

Methods

A total of 214 study subjects infected with HAdV-55 were included in our study. The study subjects were divided into those with silent infections (n=91), minor infections (n=85), and severe infections (n=38). Ten single nucleotide polymorphisms (SNPs) from CD46 were examined.

Results

Compared with the AA genotype, the TT genotype at rs2724385 (CD46, A/T) was associated with a protective effect against disease occurrence, with an odds ratio (95% confidence interval) of 0.20 (0.04-0.97) (P=0.038). There were no significant differences between the patients with minor and severe infection and those who had silent HAdV-55 infection in the other CD46 SNPs. We next compared the polymorphisms of these genes according to disease severity in HAdV-55-infected patients with clinical symptoms. The results showed that there were no significant differences between minor infections and severe infections.

Conclusions

Our results suggested that the CD46 SNP at rs2724385 is associated with the occurrence of disease in HAdV-55-infected patients. A much larger number of samples is required to understand the role of CD46 polymorphisms in the occurrence and progression of infection by HAdV-55. (Disaster Med Public Health Preparedness. 2018;12:427–430)

Type
Brief Report
Copyright
Copyright © Society for Disaster Medicine and Public Health, Inc. 2016 

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Role of CD46 Polymorphisms in the Occurrence of Disease in Young Chinese Men With Human Adenovirus Type 55 Infection
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