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Specific memory impairment in a multiple disabled male with fragile X syndrome and temporal lobe epilepsy

  • Heidi Wouters (a1), Annick Fonteyne (a1), Lieven Lagae (a2) and Peter Stiers (a1)

Abstract

Evaluation of the cognitive repercussions of an epileptic disorder and its treatment are important issues in clinical follow-up. This especially holds true for temporal lobe epilepsy (TLE) where resective surgery can be a valid treatment option. However, in patients where TLE coexists with another neurocognitive disorder, questions can arise about the precise nature of the neuropsychological deficits. The aim of the present study was to evaluate memory impairments, found in a male aged 12 years who had the dual pathology of fragile X syndrome and refractory TLE. Memory functions of this child were compared with those of a male aged 11 years 7 months with fragile X syndrome matched for intellectual functioning as indicated by highly comparable verbal (5y 5mo vs 5y 9mo) and non-verbal (7y 2mo vs 6y 1mo) cognitive age equivalents. Performance on each neuropsychological measure was evaluated twice, separately with normative data based on chronological age and on verbal or non-verbal cognitive level. A specific, distinguishable profile of task performance could be found only when controlling for general level of cognitive functioning. This made it possible to accurately evaluate neuropsychological abilities before and 6 months after anterior temporal lobe resection even in this male with a complex neurological pathology.

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Corresponding author

Laboratorium voor Neuropsychologie, KU Leuven, Medical School, Campus Gasthuisberg, Herestraat 49 – O&N Bus 504, B-3000 Leuven, Belgium. E-mail: Heidi.Wouters@med.kuleuven.be

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Specific memory impairment in a multiple disabled male with fragile X syndrome and temporal lobe epilepsy

  • Heidi Wouters (a1), Annick Fonteyne (a1), Lieven Lagae (a2) and Peter Stiers (a1)

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