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Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months


Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother–infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire—Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis–stress model at 36 months.


Corresponding author

Address correspondence and reprint requests to: Ashley Wazana, Centre for Child Development and Mental Health, Jewish General Hospital, 4335 Cote Sainte Catherine Road, Montreal, QC H3T 1E4, Canada; E-mail:


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This research was made possible by grants from the Canadian Institutes of Health Research, the March of Dimes Foundation, and the Fonds de Research du Quebec. The Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN) project has been supported by funding from the McGill Faculty of Medicine, the Blema & Arnold Steinberg Family Foundation, and the Canadian Institutes for Health Research. We thank all members and participants of the MAVAN project for their time and commitment to this research. We also thank David Brownlee, Vincent Jolivet, Amber Rider, Patricia Szymkow, and Michael Pluess for their contributions.



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Atella, L. D., DiPietro, J. A., Smith, B. A., & St. James-Roberts, I. (2003). More than meets the eye: Parental and infant contributors to maternal and paternal reports of early infant difficultness. Parenting: Science and Practice, 3, 265284. doi:10.1207/s15327922par0304_1
Auerbach, J., Geller, V., Lezer, S., Shinwell, E., Belmaker, R. H., & Levine, J., et al. (1999). Dopamine D4 receptor (DRD4) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Molecular Psychiatry, 4, 369373.
Auerbach, J. G., Benjamin, J., Faroy, M., Geller, V., & Ebstein, R. (2001). DRD4 related to infant attention and information processing: A developmental link to ADHD? Psychiatric Genetics, 11, 3135.
Auerbach, J. G., Faroy, M., Ebstein, R., Kahana, M., & Levine, J. (2001). The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament and 12-month-old infants. Journal of Child Psychology and Psychiatry, 42, 777783. doi:10.1111/1469-7610.00774
Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011). Differential susceptibility to rearing environment depending on dopamine-related genes: New evidence and a meta-analysis. Development and Psychopathology, 23, 3952.
Barker, D. J. P. (2004). The developmental origins of adult disease. Journal of the American College of Nutrition, 23, 588S595S. doi:10.1080/07315724.2004.1071942
Bayley, N. (1993). Bayley Scales of Infant Development (2nd ed.). San Antonio, TX: Psychological Corporation.
Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300304. doi:10.1111/j.1467-8721.2007.00525.x
Belsky, J., & Beaver, K. M. (2011). Cumulative-genetic plasticity, parenting and adolescent self-regulation. Journal of Child Psychology and Psychiatry, 52, 619626. doi:10.1111/j.1469-7610.2010.02327.x
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885908. doi:10.1037/a0017376
Belsky, J., Pluess, M., & Widaman, K. F. (2013). Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses. Journal of Child Psychology and Psychiatry, 54, 11351143. doi:10.1111/jcpp.12075
Blair, J., Mitchell, D., & Blair, K. (2005). The psychopath: Emotion and the brain. Oxford: Blackwell.
Bouchard, T. J. (1994). Genes, environment, and personality. Science, 264, 17001701.
Bouvette-Turcot, A. A., Fleming, A., Wazana, A., Sokolowski, M., Gaudreau, H., Gonzalez, A., et al. (2016). Maternal childhood adversity and child temperament: An association moderated by child SLC6A4 genotype. Manuscript submitted for publication.
Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity. Development and Psychopathology, 2, 271301. doi:10.1017/S0954579405050145
Braithwaite, E. C., Ramchandani, P. G., O'Connor, T. G., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Glover, V., et al. (2013). No moderating effect of 5-HTTLPR on associations between antenatal anxiety and infant behavior. Journal of the American Academy of Child & Adolescent Psychiatry, 52, 519526. doi:10.1016/j.jaac.2013.02.010
Canli, T., & Lesch, K. P. (2007). Long story short: The serotonin transporter in emotion regulation and social cognition. Nature Neuroscience, 10, 11031109. doi:10.1038/nn1964
Canli, T., Omura, K., Haas, B. W., Fallgatter, A., Constable, R. T., & Lesch, K. P. (2005). Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences, 102, 1222412229. doi:10.1073/pnas.0503880102
Caspi, A., Sugden, K., Moffit, T., Taylor, A., Craig, I., Harrington, H., et al. (2003). Influences of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386389. doi:10.1126/science.1083968
Chang, F. M., Kidd, J. R., Livak, K. J., Pakstis, A. J., & Kidd, K. K. (1996). The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Human Genetics, 98, 91101. doi:10.1007/s004390050166
Cools, R., Nakamura, K., & Daw, N. D. (2011). Serotonin and dopamine: Unifying affective, activational, and decision functions. Neuropsychopharmacology, 36, 98113. doi:10.1038/npp.2010.121
Cooper, W. O., Willy, M. E., Pont, S. J., & Ray, W. A. (2007). Increasing use of antidepressants in pregnancy. American Journal of Obstetrics and Gynecology, 196, 544-e1. doi:10.1016/j.ajog.2007.01.033
Davis, E. P., Glynn, L. M., Schetter, C. D., Hobel, C., Chicz-Demet, A., & Sandman, C. A. (2007). Prenatal exposure to maternal depression and cortisol influences infant temperament. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 737746. doi:10.1097/chi.0b013e318047b775
Davis, E. P., & Sandman, C. A. (2010). The timing of prenatal exposure to maternal cortisol and psychosocial stress is associated with human infant cognitive development. Child Development, 81, 131148. doi:10.1111/j.1467-8624.2009.01385.x
Davis, E. P., Snidman, N., Wadhwa, P. D., Glynn, L. M., Dunkel Schetter, C., & Sandman, C. A. (2004). Prenatal maternal anxiety and depression predict negative behavioral reactivity in infancy. Infancy, 6, 319331. doi:10.1207/s15327078in0603_1
Degnan, K. A., Almas, A. N., & Fox, N. A. (2010). Temperament and the environment in the etiology of childhood anxiety. Journal of Child Psychology and Psychiatry, 51, 497517. doi:10.1111/j.1469-7610.2010.02228.x
De Luca, A., Rizzardi, M., Buccino, A., Alessandroni, R., Salvioli, G. P., Filograsso, N., et al. (2003). Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants. Neurogenetics, 4, 207212.
de Weerth, C., Hees, Y., & Buitelaar, J. K. (2003). Prenatal maternal cortisol levels and infant behaviour during the first 5 months. Early Human Development, 74, 139151. doi:10.1016/S0378-3782(03)00088-4
Dray, A., Gonye, T. J., Oakley, N. R., & Tanner, T. (1976). Evidence for the existence of a raphe projection to the substantia nigra in rat. Brain Research, 113, 4557.
Duncan, L. E. (2013). Paying attention to all results, positive and negative. Journal of the American Academy of Child & Adolescent Psychiatry, 52, 462465. doi:10.1016/j.jaac.2013.02.007
Ebstein, R. P., Levine, J., Geller, V., Auerbach, J., Gritsenko, I., & Belmaker, R. H. (1998). Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament. Molecular Psychiatry, 3, 238246.
Eisenberg, N., Valiente, C., Spinrad, T. L., Cumberland, A., Liew, J., Reiser, M., et al. (2009). Longitudinal relations of children's effortful control, impulsivity, and negative emotionality to their externalizing, internalizing, and co-occurring behavior problems. Developmental Psychology, 45, 988. doi:10.1037/a0016213
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Differential susceptibility to the environment: An evolutionary–neurodevelopmental theory. Development and Psychopathology, 23, 728.
Field, T. (2011). Prenatal depression effects on early development: A review. Infant Behaviour and Development, 34, 114. doi:10.1016/j.infbeh.2010.09.008
Field, T., Diego, M., Dieter, J., Hernandez-Reif, M., Schanberg, S., Kuhn, C., et al. (2004). Prenatal depression effects on the fetus and the newborn. Infant Behavior and Development, 27, 216229. doi:10.1016/j.infbeh.2003.09.010
Fox, N. A., Henderson, H. A., Rubin, K. H., Calkins, S. D., & Schmidt, L. A. (2001). Continuity and discontinuity of behavioral inhibition and exuberance: Psychophysiological and behavioral influences across the first four years of life. Child Development, 72, 121. doi:10.1111/1467-8624.00262
Fox, N. A., Nichols, K. E., Henderson, H. A., Rubin, K., Schmidt, L., Hamer, D., et al. (2005). Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. Psychological Science, 16, 921926. doi:10.1111/j.1467-9280.2005.01637.x
Gartstein, M. A., & Rothbart, M. K. (2003). Studying infant temperament via the Revised Infant Behavior Questionnaire. Infant Behavior and Development, 26, 6486. doi:10.1016/S0163-6383(02)00169-8
Geva, R., & Feldman, R. (2008). A neurobiological model for the effects of early brainstem functioning on the development of behavior and emotion regulation in infants: Implications for prenatal and perinatal risk. Journal of Child Psychology and Psychiatry, 49, 10311041. doi:10.1111/j.1469-7610.2008.01918.x
Glover, V. (2011). Annual Research Review: Prenatal stress and the origins of psychopathology: An evolutionary perspective. Journal of Child Psychology and Psychiatry, 52, 356367. doi:10.1111/j.1469-7610.2011.02371.x
Goldsmith, H. H., & Lemery, K. S. (2000). Linking temperamental fearfulness and anxiety symptoms: A behavior-genetic perspective. Biological Psychiatry, 48, 11991209. doi:10.1016/S0006-3223(00)01003-9
Gonda, X., Fountoulakis, K. N., Juhasz, G., Rihmer, Z., Lazary, J., Laszik, A., et al. (2009). Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. European Archives of Psychiatry and Clinical Neuroscience, 259, 106113. doi:10.1007/s00406-008-0842-7
Goodman, S. H., Rouse, M. H., Connell, A. M., Broth, M. R., Hall, C. M., & Heyward, D. (2011). Maternal depression and child psychopathology: A meta-analytic review. Clinical Child and Family Psychology Review, 11, 127. doi:10.1007/s10567-010-0080-1
Gordon Green, C., Babineau, V., Bouvette-Turcot, A. A., Jolicoeur-Martineau, A., Minde, K., St-Andre, M., et al. (2014). Prenatal depression and polygenic risk: Early contributors of childhood negative emotionality. Poster session presented at the World Congress on Brain, Behavior and Emotions, Montreal.
Grant, K. A., Sandman, C. A., Wing, D. A., Dmitrieva, J., & Davis, E. P. (2015). Prenatal programming of postnatal susceptibility to memory impairments a developmental double jeopardy. Psychological Science, 26, 10541062. doi:10.1177/0956797615580299
Hariri, A. R., & Holmes, A. (2006). Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences, 10, 182191. doi:10.1016/j.tics.2006.02.011
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400403. doi:10.1126/science.1071829
Hayden, E. P., Dougherty, L. R., Maloney, B., Durbin, C. E., Olino, T. M., Nurnberger, J. I. Jr., et al. (2007). Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: A multimethod association study. Psychiatric Genetics, 17, 135142. doi:10.1097/YPG.0b013e3280147847
Hayden, E. P., Klein, D. N., Sheikh, H. I., Olino, T. M., Dougherty, L. R., Dyson, M. W., et al. (2010). The serotonin transporter promoter polymorphism and childhood positive and negative emotionality. Emotion, 10, 696. doi:10.1037/a0019527
Hill, J., Breen, G., Quinn, J., Tibu, F., Sharp, H., & Pickles, A. (2013). Evidence for interplay between genes and maternal stress in utero: Monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5 weeks. Genes, Brain and Behavior, 12, 388396. doi:10.1111/gbb.12033.
Hoaglin, D. C., & Welsch, R. E. (1978). The hat matrix in regression and ANOVA. American Statistician, 32, 1722. doi:10.2307/2683469
Holmboe, K., Nemoda, Z., Fearon, R. M. P., Sasvari-Szekely, M., & Johnson, M. H. (2011). Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament. Genes, Brain and Behavior, 10, 513522. doi:10.1111/j.1601-183X.2010.00669.x
Hu, X. Z., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., et al. (2006). Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive-disorder. American Journal of Human Genetics, 78, 815826. doi:10.1086/503850
Hyde, J. S., Mezulis, A. H., & Abramson, L. Y. (2008). The ABCs of depression: Integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression. Psychological Review, 115, 291. doi:10.1037/0033-295X.115.2.291
Kochanska, G., Philibert, R. A., & Berry, R. A. (2009). Interplay of genes and early mother-child relationship in the development of self-regulation from toddler to preschool age. Journal of Child Psychology and Psychiatry, 50, 13311338. doi:10.1111/j.1469-7610.2008.02050.x
Kramer, M. S., Wilkins, R., Gouler, L., Seguin, L., Lydon, J., Kahn, S. R., et al. (2009). Investigating socio-economic disparities in preterm birth: Evidence for selective study participants and selection bias. Paediatric and Perinatal Epidemiology, 23, 301309. doi:10.1111/j.1365-3016.2009.01042.x
Lakatos, K., Nemoda, Z., Birkas, E., Ronai, Z., Kovacs, E., Ney, K., et al. (2003). Association of D4 dopamine receptor gene and serotonin transporter promoter polymorphisms with infants’ response to novelty. Molecular Psychiatry, 8, 9097.
Lemery, K. S., Goldsmith, H. H., Klinnert, M. D., & Mrazek, D. A. (1999). Developmental models of infant and childhood temperament. Developmental Psychology, 35, 189204. doi:10.1037/0012-1649.35.1.189
Masarik, A. S., Conger, R. D., Donnellan, M. B., Stallings, M. C., Martin, M. J., Schofield, T. J., et al. (2014). For better and for worse: Genes and parenting interact to predict future behavior in romantic relationships. Journal of Family Psychology, 3, 357367.
McGrath, J. M., Records, K., & Rice, M. (2008). Maternal depression and infant temperament characteristics. Infant Behavior and Development, 31, 7180. doi:10.1016/j.infbeh.2007.07.001
Meaney, M. J. (2009). Epigenetics and the biological definition of gene x environment interactions. Child Development, 81, 4179. doi:10.1111/j.1467-8624.2009.01381.x
Oak, J. N., Oldenhof, J., & Van Tol, H. H. (2000). The dopamine D4 receptor: One decade of research. European Journal of Pharmacology, 405, 303327.
O'Connor, T., Heron, J., & Glover, V. (2002). Antenatal anxiety predicts child behavioural/emotional problems independently of postnatal depression. Journal of the American Academy of Child & Adolescent Psychiatry, 41, 14701477. doi:10.1097/00004583-200212000-00019
O'Connor, T. G., Heron, J., Golding, J., Beveridge, M., & Glover, V. (2002). Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years: Report from the Avon Longitudinal Study of Parents and Children. British Journal of Psychiatry, 180, 502508. doi:10.1192/bjp.180.6.502
O'Connor, T. G., Monk, C., & Fitelson, E. M. (2014). Practitioner Review: Maternal mood in pregnancy and child development—Implications for child psychology and psychiatry. Journal of Child Psychology and Psychiatry, 55, 99111. doi:10.1111/jcpp.12153
Odgerel, Z., Talatil, A., Hamilton, S. P., Levinson, D. F., & Weissman, M. M. (2013). Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health's Collaborative Center for Genomic Studies. Translational Psychiatry, 3, e307. doi:10.1038/tp.2013.80
O'Donnell, K., Gaudreau, H., Colalillo, S., Steiner, M., Atkinson, L., Moss, E., et al. (2014). The Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) Project: Theory and methodology. Canadian Journal of Psychiatry, 9, 497.
Parade, S. H., & Leerkes, E. M. (2008). The reliability and validity of the Infant Behaviour Questionnaire—Revised. Infant Behavior and Development, 31, 637646. doi:10.1016/j.infbeh.2008.07.009
Pauli-Pott, U., Friedl, S., Hinney, A., & Hebebrand, J. (2009). Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood. Journal of Neural Transmission, 116, 503512. doi:10.1007/s00702-008-0171-z
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulated-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828834. doi:10.1038/nn1463
Phillips, B. M., Lonigan, C. J., Driscoll, K., & Hooe, E. S. (2002). Positive and negative affectivity in children: A multitrait-multimethod investigation. Journal of Clinical Child and Adolescent Psychology, 31, 465479. doi:10.1207/S15374424JCCP3104_6
Plomin, R. (2013). Child development and molecular genetics: 14 years later. Child Development, 84, 104120. doi:10.1111/j.1467-8624.2012.01757.x
Pluess, M. (2015). Individual differences in environmental sensitivity. Child Development Perspectives, 9, 138143. doi:10.1111/cdep.12120
Pluess, M., Belsky, J., & Neuman, R. J. (2009). Prenatal smoking and attention-deficit/hyperactivity disorder: DRD4-7R as a plasticity gene. Biological Psychiatry, 66, 56. doi:10.1016/j.biopsych.2009.04.019
Pluess, M., Velders, P. F., Belsky, J., van IJzendoorn, M. H., Bakermns-Kranenburg, M. J., Jaddoe, V. W. V., et al. (2011). Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality. Biological Psychiatry, 69, 520525. doi:10.1016/j.biopsych.2010.10.006
Praschak-Rieder, N., Kennedy, J., Wilson, A. A., Hussey, D., Boovariwala, A., Willeit, M., et al. (2007). Novel 5-HTTLPR allele associates with higher serotonin transporter binding in Putamen: A [11C] DASB positron emission tomography study. Biological Psychiatry, 62, 327331. doi:10.1016/j.biopsych.2006.09.022
Putnam, S. P., Ellis, L. K., & Rothbart, M. K. (2001). The structure of temperament from infancy through adolescence. Advances in research on temperament (pp. 165182). Lengerich, Germany: Pabst Science.
Putnam, S. P., Gartstein, M. A., & Rothbart, M. K. (2006). Measurement of fine-grained aspects of toddler temperament: The Early Childhood Behavior Questionnaire. Infant Behavior and Development, 29, 386401. doi:10.1016/j.infbeh.2006.01.004
Putnam, S. P., Rothbart, M. K., & Gartstein, M. A. (2008). Homotypic and heterotypic continuity of fine-grained temperament during infancy, toddlerhood, and early childhood. Infant and Child Development, 17, 387405. doi:10.1002/ICD.582
Qiu, A., Anh, T. T., Li, Y., Chen, H., Rifkin-Graboi, A., Broekman, B. F. P., et al. (2015). Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants. Translational Psychiatry, 5, e508. doi:10.1038/tp.2015.3
Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385401. doi:10.1177/014662167700100306
Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B. R., Sim, L. W., Tint, M. T., et al. (2013). Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth. Biological Psychiatry, 74, 837844. doi:10.1016/j.biopsych.2013.06.019
Rothbart, M. (1981). Measurement of temperament in infancy. Child Development, 53, 569578.
Sameroff, A., Gutman, L. M., & Peck, S. C. (2003). Adaptation among youth facing multiple risks: Prospective research findings. In Luthar, S. (Ed.), Resilience and vulnerability: Adaptation in context of childhood adversities (pp. 364391). New York: Cambridge University Press.
Sandman, C. A., Buss, C., Head, K., & Davis, E. P. (2015). Fetal exposure to maternal depressive symptoms is associated with cortical thickness in late childhood. Biological Psychiatry, 77, 324334. doi:10.1016/j.biopsych.2014.06.025
Saudino, K. J. (2009). The development of temperament from a behavioural genetics perspective. Advances in Child Development and Behaviour, 37, 201231. doi:10.1016/S0065-2407(09)03705-7
Seifer, R., Sameroff, A. J., Barrett, L. C., & Krafchuk, E. (1994). Infant temperament measured by multiple observations and mothers report. Child Development, 65, 14781490. doi:10.1111/j.1467-8624.1994.tb00830.x
Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics, 127B, 8589. doi:10.1002/ajmg.b.20158
Smith, H. J., Sheikh, H. I., Dyson, M. W., Olino, T. M., Laptook, R. S., Durbin, C. E., et al. (2012). Parenting and child DRD4 genotype interact to predict children's early emerging effortful control. Child Development, 83, 19321944.
Sonuga-Barke, E. J., Oades, R. D., Psychogiou, L., Chen, W., Franke, B., Buitelaar, J., et al. (2009). Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: The case of conduct and emotional problems in attention deficit/hyperactivity disorder. Journal of Child Psychology and Psychiatry, 50, 10521063. doi:10.1111/j.1469-7610.2009.02095.x
Stevens, J. (1986). Applied multivariate statistics for the social sciences. Hillsdale, NJ: Erlbaum.
Susman, E. J., Schmeelk, K. H., Ponirakis, A., & Gariepy, J. L. (2001). Maternal prenatal, postpartum, and concurrent stressors and temperament in 3-year-olds: A person and variable analysis. Developmental Psychopathology, 13, 629652.
Tsai, C. T. (1989). Involvement of serotonin in mediation of inhibition of substantia nigra neurons by noxious stimuli. Brain Research Bulletin, 23, 121127.
Uher, R. (2008). The implications of gene-environment interactions in depression: Will cause inform cure? Molecular Psychiatry, 13, 10701078. doi:10.1038/mp.2008.92
Vadovicova, K., & Gasparotti, R. (2014). Reward and adversity processing circuits: Their competition and interaction with dopamine and serotonin signalling. Science Open Research. Advance online publication. doi:10.14293/S2199-1006.1.SOR-LIFE.AEKZPZ.v12
van Batenburg-Eddes, T., Brion, M. J., Henrichs, J., Jaddoe, V. W. V., Hofman, A., Verhulst, F. C., et al. (2013). Parental depressive and anxiety symptoms during pregnancy and attention problems in children: A cross-cohort consistency study. Journal of Child Psychology and Psychiatry, 54, 591600. doi:10.1111/jcpp.12023
van Buuren, S., Boshuizen, H. C., & Knook, D. L. (1999). Multiple imputation of missing blood pressure covariates in survival analysis. Statistics in Medicine, 18, 681694.
van Buuren, S., & Groothuis-Oudshoorn, K. (2011). MICE: Multivariate imputation by chained equations in R. Journal of Statistical Software, 45, 167.
Widaman, K. F., Helm, J. L., Castro-Schilo, L., Pluess, M., Stallings, M. C., & Belsky, J. (2012). Distinguishing ordinal and disordinal interactions. Psychological Methods, 17, 615622. doi:10.1037/a0030003
Weikum, W. M., Brain, U., Chau, C. M., Grunau, R. E., Boyce, W. T., Diamond, A., et al. (2013). Prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and serotonin transporter promoter genotype (SLC6A4) influence executive functions at 6 years of age. Frontiers in Cellular Neuroscience, 7, 180. doi:10.3389/fncel.2013.00180
Wong, M. Y., Day, N. E., Luan, J. A., Chan, K. P., & Wareham, N. J. (2003). The detection of gene–environment interaction for continuous traits: Should we deal with measurement error by bigger studies or better measurement? International Journal of Epidemiology, 2, 5157. doi:10.1093/ije/dyg002
Zohsel, K., Buchmann, A. F., Blomeyer, D., Hohm, E., Schmidt, M. H., Esser, G., et al. (2014). Mothers’ prenatal stress and their children's antisocial outcomes—A moderating role for the dopamine D4 receptor (DRD4) gene. Journal of Child Psychology and Psychiatry, 55, 6976. doi:10.1111/jcpp.12138

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Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months


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