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Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD

Published online by Cambridge University Press:  25 January 2021

Sara A. Heyn Open the ORCID record for Sara A. Heyn [Opens in a new window] ,
Collin Schmit ,
Taylor J. Keding ,
Richard Wolf  and
Ryan J. Herringa
Sara A. Heyn*
Affiliation:
Neuroscience and Public Policy Program, University of Wisconsin-Madison, Madison, WI, USA Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA
Collin Schmit
Affiliation:
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
Taylor J. Keding
Affiliation:
Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA
Richard Wolf
Affiliation:
Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA
Ryan J. Herringa
Affiliation:
Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA
*
Author for Correspondence: Sara Heyn, Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Blvd. Rm 1329, Madison, WI53719; E-mail: sheyn@wisc.edu
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Abstract

Despite broad evidence suggesting that adversity-exposed youth experience an impaired ability to recognize emotion in others, the underlying biological mechanisms remains elusive. This study uses a multimethod approach to target the neurological substrates of this phenomenon in a well-phenotyped sample of youth meeting diagnostic criteria for posttraumatic stress disorder (PTSD). Twenty-one PTSD-afflicted youth and 23 typically developing (TD) controls completed clinical interview schedules, an emotion recognition task with eye-tracking, and an implicit emotion processing task during functional magnetic resonance imaging )fMRI). PTSD was associated with decreased accuracy in identification of angry, disgust, and neutral faces as compared to TD youth. Of note, these impairments occurred despite the normal deployment of visual attention in youth with PTSD relative to TD youth. Correlation with a related fMRI task revealed a group by accuracy interaction for amygdala–hippocampus functional connectivity (FC) for angry expressions, where TD youth showed a positive relationship between anger accuracy and amygdala–hippocampus FC; this relationship was reversed in youth with PTSD. These findings are a novel characterization of impaired threat recognition within a well-phenotyped population of severe pediatric PTSD. Further, the differential amygdala–hippocampus FC identified in youth with PTSD may imply aberrant efficiency of emotional contextualization circuits.

Keywords

adolescentemotionfunctional neuroimagingposttraumatic stress disorders
Type
Regular Article
Information
Development and Psychopathology , Volume 34 , Issue 3 , August 2022 , pp. 946 - 956
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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