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The development of thought problems: A longitudinal family risk study of offspring of bipolar, unipolar, and well parents

  • Bonnie Klimes-Dougan (a1), Christopher David Desjardins (a1), Matthew G. James (a1), Angela J. Narayan (a1), Jeffrey D. Long (a2), Kathryn R. Cullen (a1), Philip W. Gold (a3) and Pedro E. Martinez (a3)...

Abstract

There is growing evidence that many offspring of parents with bipolar disorder (BD) will develop moderate to severe forms of psychopathology during childhood and adolescence, including thought problems. The purpose of this study was to evaluate the developmental progression of thought problems within the context of a family risk study. Repeated assessments of thought problems, spanning approximately 15 years, were conducted in offspring (N = 192 from 98 families) of parents diagnosed with BD (O-BD), unipolar depression (O-UNI), or no significant psychiatric or medical problems (O-WELL). Survival analysis showed that the O-BD group had the greatest estimated probability of developing thought problems over time, followed by O-UNI, and then O-WELL and O-BD exhibiting higher levels of persistence than O-WELL. Parent-reported thought problems in childhood and adolescence predicted a range of problems in young adulthood. Disturbances in reality testing and other atypical behaviors are likely to disrupt progression through important developmental periods and to associate with poor outcomes. These findings are likely relevant to preventing the occurrence or progression of problems in offspring of bipolar parents. The study of thought problems across development represents an important area of continued research in children at risk for development of affective disorders.

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Corresponding author

Address correspondence and reprint requests to: Bonnie Klimes-Dougan, Psychology Department, University of Minnesota, 75 East River Road, 412 Elliot Hall, Minneapolis, MN 55455; E-mail: klimes@umn.edu.

References

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Abdellaoui, A., Bartels, M., Hudziak, J. J., Rizzu, P., van Beijsterveldt, T. C., & Broomsma, D. I. (2008). Genetic influences on thought problems in 7-year-olds: A twin-study of genetic, environmental, and rater effects. Twin Research and Human Genetics, 11, 571578.
Abdellaoui, A., de Moor, M. H. M., Geels, L. M., van Beek, J. H. D. A., Willemsen, G., & Boomsma, D. I. (2012). Thought problems from adolescence to adulthood: Measurement invariance and longitudinal heritability. Behavior Genetics, 42, 1929.
Achenbach, T. M. (1991). Manual for the Child Behavior Checklist/4–18 and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M. (1997). Manual for the Young Adult Behavior Checklist and Young Adult Self-Report. Burlington, VT: University of Vermont, Department of Psychiatry.
Adrian, C., & Hammen, C. (1993). Stress exposure and stress generation in children of depressed mothers. Journal of Consulting and Clinical Psychology, 61, 354359.
Bartels, M., van de Aa, N., van Beijsterveldt, C. E. M., Middledorp, C. M., & Boomsma, D. I. (2011). Adolescent self-report of emotional and behavioral problems: Interactions of genetic factors with sex and age. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 20, 3552.
Bates, D., & Maechler, M. (2010). Lme4: Linear mixed-effects models using S4 classes. R package version 0.999375-33 [Computer software]. Retrieved from http://cran.r-project.org/web/packages/lme4/index.html
Birmaher, B., Axelson, D., Goldstein, B., Monk, K., Kalas, C., Obreja, M., et al. (2010). Psychiatric disorders in preschool offspring of parents with bipolar disorder: The Pittsburgh Bipolar Offspring Study (BIOS). American Journal of Psychiatry, 167, 321330.
Bolte, S., Dickhut, H., & Poustka, F. (1999). Patterns of parent-reported problems indicative in autism. Psychopathology, 32, 9397.
Bongers, I. L., Koot, H. M., van der Ende, J., & Verhulst, F. C. (2003). The normative development of child and adolescent problem behavior. Journal of Abnormal Psychology, 112, 179192.
Carlson, G. A., & Kelly, K. L. (1998). Manic symptoms in psychiatrically hospitalized children—What do they mean? Journal of Affective Disorders, 51, 123135.
Chang, K., Steiner, H., & Ketter, T. (2003). Studies of offspring of parents with bipolar disorder. American Journal of Medical Genetics, 123C, 2635.
Cicchetti, D. (2010). A developmental psychopathology perspective on bipolar disorder. In J Miklowitz, D. & Cicchetti, D. (Eds.), Understanding bipolar disorder: A developmental psychopathology perspective (pp. 132). New York: Cambridge University Press.
Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597600.
Craddock, N., & Jones, I. (2001). Molecular genetics of bipolar disorder. British Journal of Psychiatry, 178, 128133.
DelBello, M. P., & Geller, B. (2001). Review of studies of child and adolescent offspring of bipolar parents. Bipolar Disorder, 3, 325334.
Dienes, K. A., Chang, K. D., Blasey, C. M., Adleman, N. E., & Steiner, H. (2002). Characterization of children of bipolar parents by parent report CBCL. Journal of Psychiatric Research, 36, 337345.
Diler, R. S., Birmaher, B., Axelson, D., Obreja, M., Monk, K., Hickey, M. B., et al. (2011). Dimensional psychopathology in offspring of parents with bipolar disorder. Bipolar Disorders, 13, 670678.
Diler, R. S., Birmaher, B., & Miklowitz, D. J. (2010). Clinical presentation and longitudinal course of bipolar spectrum disorders in children and adolescents. In J Miklowitz, D. & Cicchetti, D. (Eds.), Understanding bipolar disorder: A developmental psychopathology perspective (pp. 135165). New York: Cambridge University Press.
Djurovic, S., Gustafsson, O., Mattingsdal, M., Athanasiu, L., Bjella, T., Tesli, M., et al. (2010). A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. Journal of Affective Disorders, 126, 312316.
Duffy, A., Alda, M., Hajek, T., Sherry, S. B., & Grof, P. (2010). Early stages in the development of bipolar disorder. Journal of Affective Disorder, 121, 127135.
Duffy, A., Alda, M., Kutcher, S., Cavazzoni, P., Robertson, C., Grof, E., et al. (2002). A prospective study of offspring of bipolar parents responsive and nonresponsive to lithium treatment. Journal of Clinical Psychiatry, 63, 11711178.
Dunayevich, E., & Keck, P. E. (2000). Prevalence and description of psychotic features in bipolar mania. Current Psychiatry Reports, 2, 286290.
Endicott, J., Spitzer, R. L., Fleiss, J. L., & Cohen, J. (1976). The global assessment scale: A procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766771.
Ferdinand, R. F., & Verhulst, F. C. (1995). Psychopathology from adolescence into young adulthood: An 8-year follow-up study. American Journal of Psychiatry, 152, 15861594.
Fitzmaurice, G. M., Laird, N. M., & Ware, J. H. (2004). Applied longitudinal analysis. New York: Wiley.
Fonseca-Pedrero, E., Santarén-Rosell, M., Lemos-Giráldez, S., Paino, M., Sierra-Baigrie, S., & Muñiz, J. (2011). Psychotic-like experiences in the adolescent general population. Actas Españolas de Psiquiatría, 39, 155162.
Giles, L. L., DelBello, M. P., Stanford, K. E., & Strakowski, S. M. (2007). Child Behavior Checklist profiles of children and adolescents with and at high risk for developing bipolar disorder. Child Psychiatry and Human Development, 38, 4755.
Goldberg, J. F. (2010). A developmental perspective on the course of bipolar disorder in adulthood. In Miklowitz, D. J. & Cicchetti, D. (Eds.), Understanding bipolar disorder: A developmental psychopathology perspective (pp. 192222). New York: Cambridge University Press.
Goodman, S. H., & Gotlib, I. H. (2002). Children of depressed parents: Mechanisms of risk and implications for treatment. Washington, DC: American Psychological Association.
Grambsch, P. M., & Therneau, T. M. (1994). Proportional hazards tests and diagnostics based on weighted residuals. Biometrika, 81, 515526.
Hillegers, M. H. J., Burger, H., Wals, M., Reichart, C. G., Verhulst, F. C., Nolen, W. A., et al. (2004). Impact of stressful life events, familial loading and their interaction on the onset of mood disorders: Study in a high-risk cohort of adolescent offspring of parents with bipolar disorder. British Journal of Psychiatry, 185, 97101.
Hollingshead, A. B. (1975). Four-Factor Index of Social Status. New Haven, CT: Yale University, Sociology Department.
Hughes, E. K., & Gullone, E. (2010). Discrepancies between adolescent, mother, and father reports of adolescent internalizing symptom levels and their association with parent symptoms. Journal of Clinical Psychology, 66, 978995.
Ivarsson, T., & Larsson, B. (2008). The Obsessive–Compulsive Symptom (OCS) Scale of the Child Behavior Checklist: A comparison between Swedish children with obsessive–compulsive disorder from a specialized unit, regular outpatients and a school sample. Journal of Anxiety Disorders, 22, 11721179.
Ivarsson, T., Melin, K., & Wallin, L. (2008). Categorical and dimensional aspects of comorbidity in obsessive–compulsive disorder (OCD). European Journal of Adolescent Psychiatry, 17, 2031.
Karatekin, C., White, T., & Bingham, C. (2010). Shared and nonshared symptoms in youth-onset psychosis and ADHD. Journal of Attention Disorders, 14, 121131.
Kasius, M. C., Ferdinand, R. F., van den Berg, H., & Verhulst, F. C. (1997). Associations between different diagnostic approaches for child and adolescent psychopathology. Journal of Child Psychology and Psychiatry, 38, 625632.
Kelsoe, J. R. (2003). Arguments for the genetic basis of the bipolar spectrum. Journal of Affective Disorders, 73, 183197.
Klein, J. P., & Moeschberger, M. L. (2003). Survival analysis techniques for censored and truncated data (2nd ed.). New York: Springer.
Klimes-Dougan, B. (1998). Screening for suicidal ideation in children and adolescents: Methodological considerations. Journal of Adolescence, 21, 435444.
Klimes-Dougan, B., Desjardins, C. D., James, M. G., Narayan, A. J., Long, J. D., Cullen, K. R. et al. (2011). Disturbances in reality testing: Understanding risks for descendants of bipolar disorder. Paper presented at the American Academy of Child and Adolescent Psychiatry, Toronto, October.
Klimes-Dougan, B., Free, K., Ronsaville, D., Stilwell, J., Welsh, C. J., & Radke-Yarrow, M. (1999). Suicidal ideation and attempts: A longitudinal investigation of children of depressed and well mothers. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 651659.
Klimes-Dougan, B., Long, J. D., Lee, C. Y., Ronsaville, D. S., Gold, P. W., & Martinez, P. E. (2010). Continuity and cascade in offspring of bipolar parents: A longitudinal study of externalizing, internalizing, and thought problems. Development and Psychopathology, 22, 849866.
Kraepelin, E. (1906). Uber sprachstorungen im traume. Leizpig: Engelmann.
Lapalme, M., Hodgins, S., & LaRoche, C. (1997). Children of parents with bipolar disorder: A meta-analysis of risk for mental disorders. Canadian Journal of Psychiatry, 42, 623631.
Laursen, T. M., Agerbo, E., & Pedersen, C. B. (2009). Bipolar disorder, schizoaffective disorder, and schizophrenia overlap: A new comorbidity index. Journal of Clinical Psychiatry, 70, 14321438.
Macfie, J., Cicchetti, D., & Toth, S. L. (2001). The development of dissociation in maltreated preschool-aged children. Development and Psychopathology, 12, 233254.
Masten, A. S., Burt, K. B., & Coatsworth, J. D. (2006). Competence and psychopathology in development. In Ciccheti, D. & Cohen, D. (Eds.), Developmental psychopathology: Vol. 3. Risk, disorder, and adaptation (2nd ed., pp. 696738). Hoboken, NJ: Wiley.
McGuffin, P., Rijsdijk, F., Andrew, M., Sham, P., Katz, R., & Cardno, A. (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Archives of General Psychiatry, 60, 497502.
Meyer, S. E., Carlson, G. A., Wiggs, E. A., Martinez, P. E., Ronsaville, D. S., Klimes-Dougan, B., et al. (2004). A prospective study of the association among impaired executive functioning, childhood attentional problems, and the development of bipolar disorder. Development and Psychopathology, 16, 461476.
Miklowitz, D. J. (2011). Functional impairment, stress, and psychosocial intervention in bipolar disorder. Current Psychiatry Reports. Advance online publication.
Petresco, S., Gutt, E. K., Krelling, R., Lotufo Neto, F., Rohd, L. A., & Moreno, R. A. (2009). The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center. Revista Brazileira Psiquiatria, 31, 240246.
R Development Core Team. (2010). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Retrieved from http://www.R-project.org
Raadal, M., Milgrom, P., Cauce, A. M., & Mancl, L. (1994). Behavior problems in 5- to 11-year-old children from low-income families. Journal of the American Academy of Child & Adolescent Psychiatry, 33, 10171025.
Radke-Yarrow, M., & Klimes-Dougan, B. (1997). Children of depressed mothers: A developmental and interactional perspective. In Luthar, S., Burack, J., Cicchetti, D., & Weisz, J. (Eds.), Developmental psychopathology: Perspectives on adjustment, risk, and disorder. New York: Cambridge University Press.
Radke-Yarrow, M., & Klimes-Dougan, B. (2002). Parental depression and offspring disorders: A developmental perspective. In Goodman, S. H. & Gotlib, I. H. (Eds.), Children of depressed parents: Mechanisms of risk and implications for treatment. Washington, DC: American Psychological Association.
Radke-Yarrow, M., Martinez, P., Mayfield, A., & Ronsaville, D. (1998). Children of depressed mothers: From early childhood to maturity. Cambridge: Cambridge University Press.
Reichart, C. G., Wals, M., Hillegers, M. H. J., Ormel, J., Nolen, W. A., & Verhulst, F. C. (2004). Psychopathology in the adolescent offspring of bipolar parents. Journal of Affective Disorders, 78, 6771.
Richters, J., & Pellegrini, D. (1989). Depressed mothers’ judgements about their children: An examination of the depression–distortion hypothesis. Child Development, 60, 10681075.
Spitzer, R. L., & Endicott, J. (1977). The Schedule for Affective Disorders and Schizophrenia: Lifetime version. New York: New York State Psychiatric Institute.
Spitzer, R. L., Robins, E., & Endicott, J. (1978). Research diagnostic criteria (RDC) for a selected group of functional disorders. New York: New York State Psychiatric Institute.
Spitzer, R. L., Williams, J. B. W., Gibbon, M., & First, M. B. (1992). The Structured Clinical Interview for DSM-III-R (SCID) I: History, rationale, and description. Archives of General Psychiatry, 49, 624629.
Therneau, T. (2009). Coxme: Mixed Effects Cox Models. R package version 2.0 [Computer software]. Retrieved from http://CRAN.R-project.org/package=coxme
Tick, N. T., van der Ende, J., & Verhulst, F. C. (2008). Ten-year trends in self-reported emotional and behavioral problems of Dutch adolescents. Social Psychiatry Psychiatric Epidemiology, 43, 349355.
van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., & Krabbendam, L. (2009). A systematic review and meta-analysis of the psychosis continuum: Evidence for a psychosis proneness–persistence–impairment model of psychotic disorder. Psychological Medicine, 39, 179195.
Verhulst, F. C., van der Ende, J., & Koot, H. M. (1996). Handleiding voor de CBCL/4–18 [Manual for the CBCL/4–18]. Sophia, The Netherlands: Afdeling Kinder-en Jeugdpsychiatrie.
Volkmar, F. R., Becker, D. F., King, R. A., & McGlashan, T. H. (1995). Psychotic processes. In Cicchetti, D., & Cohen, D. J. (Eds.), Developmental psychopathology: Vol. 2. Risk, disorder, and adaptation (pp. 512534). New York: Wiley.
Wals, M., Reichart, C. G., Hillegers, M. H. J., Nolen, W. A., Van Os, J., Ormel, J., et al. (2006). Prediction of change in level of problem behavior among children of bipolar parents. Acta Psychiatrica Scandinavia, 113, 2330.
Wilcutt, E., & McQueen, M. (2010). Genetic and environmental vulnerability in bipolar spectrum disorders. In Miklowitz, D. J. & Cicchetti, D. (Eds.), Understanding bipolar disorder: A developmental psychopathology perspective (pp. 225259). New York: Cambridge University Press.

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