Skip to main content Accessibility help
×
Home

What Does Imaging Add to the Management of Alzheimer's Disease?

  • Gary W. Small

Abstract

The prevalence of Alzheimer's disease (AD) and dementia continues to rise. However, a significant number of patients are undiagnosed or untreated. Given the complexities of detecting cognitive impairment and the early signs of AD, this review discusses how advances in brain imaging can help assist in improving overall management. Imaging techniques and surrogate markers may provide unique opportunities to diagnose accurately AD in presymptomatic stages with practical consequences for patients, caregivers, and physicians. The possible outcomes for using imaging and surrogate markers as adjuncts to clinical examination and as screening tools for AD, as well as tangible and intangible advantages to early diagnosis and treatment, will be discussed. The specific value of using advanced serial imaging in patients with a genetic disposition to AD will be evaluated. If neurons can be protected from neurodegenerative damage in early stages, this may preserve patient cognition, function, and quality of life, and may confer considerable societal healthcare benefits.

Copyright

Corresponding author

Please direct all correspondence to: Gary W. Small, MD, Neuropsychiatric Institute, University of California, Los Angeles, 760 Westwood Plaza, no. 88201NPI, Los Angeles, CA 90024. Tel: 310-825-0291; Fax: 310-825-3910; E-mail: gsmall@mednet.ucla.

References

Hide All
1.Knopman, DS, DeKosky, ST, Cummings, JL, et al.Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:11431153.
2.Bookheimer, SY, Strojwas, MH, Cohen, MS, et al.Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med. 2000;343:450456.
3.Silverman, DH, Small, GW, Chang, CY, et al.Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA. 2001;286:21202127.
4.Lim, A, Tsuang, D, Kukull, W, et al.Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. J Am Geriatr Soc. 1999:47:564569.
5.Small, GW, Ercoli, LM, Silverman, DH, et al.Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Nad Acad Sri U S A. 2000;97:60376042.
6.Small, GW. The Memory Bible. New York, NY: Hyperion. 2002.
7.Shoghi-Jadid, K, Small, GW, Agdeppa, ED, et al.Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002;10:2435.

Related content

Powered by UNSILO

What Does Imaging Add to the Management of Alzheimer's Disease?

  • Gary W. Small

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.