Skip to main content Accessibility help
×
Home

Repetitive TMS as a Probe of Mood In Health and Disease

  • Mark S. George (a1) (a2) (a3), Andrew M. Speer (a1), Eric M. Wassermann (a3), Timothy A. Kimbrell (a4), Wendol A. William (a5), Charles H. Kellner (a1), S. Craig Risch (a1), Laurie Stallings (a2) and Robert M. Post (a4)...

Abstract

Recent advances in functional neuroimaging (including positron emission tomography, single-photon emission tomography, and fast magnetic resonance imaging) have allowed better understanding of the brain regions involved in regulating normal and pathological moods. Repetitive transcranial magnetic stimulation (rTMS) has the ability to stimulate or temporarily impair brain regions, which makes it a powerful tool for directly testing theories of the neurologic basis of mood regulation.

Copyright

References

Hide All
1.George, MS, Ketter, TA, Post, RM. What functional imaging studies have revealed about the brain basis of mood and emotion. In: Panksepp, J, ed. Advances in Biological Psychiatry. Greenwich, Conn: JAI Press; 1997:63113.
2.Ketter, TA, George, MS, Kimbrell, TA, et al.Functional brain imaging, limbic function, and affective disorders. The Neuroscientist. 1996;2:5565.
3.George, MS, Post, RM, Ketter, TA, et al.Neural mechanisms of mood disorders. Current Review of Mood and Anxiety Disorders. 1997;1:7183.
4.George, MS, Ketter, TA, Post, RM. Prefrontal cortex dysfunction in clinical depression. Depression. 1994;2:5972.
5.Nobler, MS, Sackeim, HA, Prohovnik, I, et al.Regional cerebral blood flow in mood disorders: III. treatment and clinical response. Arch Gen Psychiatry. 1994;51:884897.
6.Baxter, LR Jr, Phelps, ME, Mazziotta, JC, et al.Cerebral metabolic rates for glucose in mood disorders: studies with positron emission tomography and fluorodeoxyglucose F 18. Arch Gen Psychiatry. 1985;42:441447.
7.Baxter, LR Jr, Schwartz, JM, Phelps, ME, et al.Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243250.
8.Andreason, PJ, Altemus, M, Zametkin, AJ, et al.Regional cerebral glucose metabolism in bulimia nervosa. Am J Psychiatry. 1992;149:15061513.
9.Drevets, WC, Videen, TO, Preskorn, SH, et al.A functional anatomical study of unipolar depression. J Neuroscience. 1992;12:36283641.
10.Stevens, JR, Mark, VH, Ervin, F, et al.Deep temporal stimulation in man. Arch Neurol. 1969;21:157.
11.Halgren, E, Walter, RD, Cherlow, DG, et al.Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain. 1978;101:83117.
12.Heath, RG. Pleasure response of human subjects to direct stimulation of the brain: physiologic and psychodynamic considerations. In: Heath, RG, ed. The Role of Pleasure in Behavior. New York, NY: Paul B. Hoeber; 1964:219243.
13.Penfield, W, Perot, P. The brain's record of auditory and visual experience: a final summary and discussion. Brain. 1963;86:595696.
14.Heath, RG. Activity of the human brain during emotional thought. In: Heath, RG, ed. The Role of Pleasure in Behavior. New York, NY: Paul B. Hoeber; 1994:
15.Heath, RG, Mickie, WA. Evaluation of seven years experience with depth electrode studies in human patients. In: Ramey, ER, O'Doherty, D, eds. Electrical Studies of the Unanesthetized Brain. New York, NY: Paul B. Hoeber, 1960:214247.
16.Ketter, TA, Andreason, PJ, George, MS, Herscovitch, P, Post, RM. Paralimbic rCBF increases during procaine-induced psychosensory and emotional experiences. Biol Psychiatry. 1993;33:66A. [Abstract 107]
17.Kellner, CH, Post, RM, Putnam, F, et al.Intravenous procaine as a probe of limbic system activity in psychiatric patients and normal controls. Biol Psychiatry. 1987;22:11071126.
18.Parekh, PI, Spencer, JW, George, MS, et al.Procaine-induced increases in limbic rCBF correlate positively with increases in occipital and temporal EEG fast activity. Brain Topogr. 1995;7:209216.
19.Ketter, TA, Andreason, PJ, George, MS, et al.Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry. 1996;53:5969.
20.Papez, JW. A proposed mechanism of emotion. Arch Neurol Psychiatry. 1937;38:725743.
21.Ketter, TA, Andreason, PJ, George, MS, Pazzaglia, PJ, Marangell, LM, Post, RM. Blunted CBF response to procaine in mood disorders. Presented at the American Psychiatric Association Annual Meeting; Philadelphia, PA. [134; Abstract NR297]
22.Trivedi, MH, Blackburn, T, Lewis, S, et al.Effects of amphetamine in major depressive disorder using functional MRI. Biol Psychiatry. 1995;37:657. Abstract.
23.Pardo, JV, Pardo, PJ, Raichle, ME. Neural correlates of self-induced dysphoria. Am J Psychiatry. 1993;150:713719.
24.George, MS, Ketter, TA, Parekh, PI, et al.Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995;152:341351.
25.Ross, ED, Homan, RW, Buck, R. Differential hemispheric lateralization of primary and social emotions: implications for developing a comprehensive neurology for emotions, repression and the subconscious. Neuropsychiatry, Neuropsychology, and Behavioral Neurology. 1994;7:119.
26.Sackeim, HA, Greenberg, MS, Weiman, AL, et al.Hemispheric asymmetry in the expression of positive and negative emotions: neurologic evidence. Arch Neurol. 1982;39:210218.
27.Sackeim, HA, Gur, RC. Lateral asymmetry in intensity of emotional expression. Neuropsychologia. 1978;163:473481.
28.Sackeim, HA, Gur, RC, Saucy, MC. Emotions are expressed more intensely on the left side of the face. Science. 1978;202:434436.
29.Wada, J, Rasmussen, T. Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance: experimental and clinical observations. J Neurosurg. 1960;17:266282.
30.Christianson, SA, Saisa, J, Garvill, J, et al.Hemispheric inactivation and mood-state changes. Brain Cogn. 1993;23:127144.
31.George, MS, Parekh, PI, Rosinsky, N, et al.Understanding emotional prosody activates right hemisphere regions. Arch Neurol. 1996;53:665670.
32.House, A, Dennis, M, Warlow, C, et al.Mood disorders after stroke and their relation to lesion location. Brain. 1990;113:11131129.
33.Sharpe, M, Hawton, K, House, A, et al.Mood disorders in long-term survivors of stroke: associations with brain lesion location and volume. Psychol Med. 1990;20:815828.
34.Sackeim, HA. Emotion, disorders of mood, and hemispheric functional specialization. In: Carroll, BJ, Barrett, JE, eds. Psychopathology and the Brain. New York, NY: Raven Press; 1991:209242.
35.George, MS, Wassermann, EM, Williams, W, et al.Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996;8:172180.
36.Pascual-Leone, A, Catala, MD, Pascual, AP. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood. Neurology. 1996;46:499502.
37.Greenberg, BD, George, MS, Dearing, J, et al.Effect of repetitive transcranial magnetic stimulation on mood, anxiety and obsessive compulsive symptoms in OCD. APA New Research Program. 1995;191. [Abstract]
38.Hoflich, G, Kasper, S, Hufnagel, A, et al.Application of transcranial magnetic stimulation in treatment of drug-resistant major depression: a report of two cases. Human Psychopharmacology. 1993;8:361365.
39.Grisaru, N, Yarovslavsky, U, Abarbanel, J, et al.Transcranial magnetic stimulation in depression and schizophrenia. European Neuropsychopharmacology. 1994;4:287288.
40.Kolbinger, HM, Hoflich, G, Hufnagel, A, et al.Transcranial magnetic stimulation (TMS) in the treatment of major depression: a pilot study. Human Psychopharmacology. 1995;10:305310.
41.George, MS, Wassermann, EM. Rapid-rate transcranial magnetic stimulation (rTMS) and ECT. Convuls Ther. 1994;10:251253.
42.George, MS, Wassermann, EM, Williams, WA, et al.Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. NeuroReport. 1995;6:18531856.
43.Pascual-Leone, A, Rubio, B, Pallardo, F, et al.Beneficial effect of rapid-rate transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in drug-resistant depression. Lancet. 1996;347:233237.
44.George, MS, Wassermann, EM, Williams, WA, et al. Daily left prefrontal rTMS in outpatient depression: initial results of a double-blind placebo controlled crossover trial. Presented at the American Psychiatric Association Annual Meeting, New York, 1996. [Abstract]
45.Wassermann, EM, Wang, B, Zeffiro, TA, et al.Locating the motor cortex on the MR1 with transcranial magnetic stimulation and PET. Neuroimage. 1996;1:19.
46.George, MS, Wassermann, EM, Kimbrell, T, et al.An overview of initial studies combining conventional functional imaging (PET, SPECT, fMRI) with transcranial magnetic stimulation (TMS) to actively probe brain-behavior relationships. J Neuropsychiatry Clin Neurosci. [Abstract]
47.Roberts, DR, Vincent, DJ, Speer, AM, et al.Multi-modality mapping of motor cortex: comparing echoplanar BOLD fMRI and transcranial magnetic stimulation. J Neural Transm. In press.
48.George, MS, Wassermann, EM, Post, RM. Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century. J Neuropsychiatry Clin Neurosci. 1996;8:373382.

Related content

Powered by UNSILO

Repetitive TMS as a Probe of Mood In Health and Disease

  • Mark S. George (a1) (a2) (a3), Andrew M. Speer (a1), Eric M. Wassermann (a3), Timothy A. Kimbrell (a4), Wendol A. William (a5), Charles H. Kellner (a1), S. Craig Risch (a1), Laurie Stallings (a2) and Robert M. Post (a4)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.