Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-20T03:48:13.479Z Has data issue: false hasContentIssue false
  • English
  • Français

New Methods of Brain Stimulation Are Improving Research and Therapy in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014

Mark S. George
Get access Rights & Permissions [Opens in a new window]

Abstract

Over the past decade, new functional neuroimaging tools have enabled researchers to identify the specific brain regions involved in obsessive-compulsive disorder (OCD). More recently, researchers have perfected several new techniques for stimulating the brain. With some exceptions, these new brain stimulation techniques are regionally specific and less invasive than older methods. As a class, these “somatic interventions” build on prior neuroanatomic information about OCD. This article reviews the past and current status of these brain stimulation methodologies, which promise to revolutionize neuropsychiatric research and therapy over the next 10 to 20 years. As the brain circuits in OCD and the pharmacology within those circuits become better understood, these brain stimulation techniques hold particular promise in helping to understand and perhaps treat OCD.

Type
Academic Supplement
Information
CNS Spectrums , Volume 5 , supplement S4: Proceedings From the Fourth Annual IOCDC , June 2000 , pp. 12 - 17
Copyright
Copyright © Cambridge University Press 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Greenberg, BD, Rauch, SL. TMS in anxiety disorders. In: MS, George, RH, Belmaker, eds. Transcranial Magnetic Stimulation in Neuropsychiatry. Washington, DC: American Psychiatric Press; 2000:209–222.Google Scholar
2.Marangell, LB, George, MS, Callahan, AM, et al.Effects of intrathecal thyrotropin-releasing hormone (TRH) in refractory depressed patients. Arch Gen Psychiatry. 1997;54:214–222.CrossRefGoogle ScholarPubMed
3.Impastato, DJ. The story of electroshock treatment. Am J Psychiatry. 1960;116:1113–1114.CrossRefGoogle Scholar
4.Lisanby, SH, Sackeim, HA. Therapeutic brain interventions and the nature of emotion. In: Borod, J, ed. The Neuropsychology of Emotion. New York, NY: Oxford University Press; 2000.Google Scholar
5.Sackeim, HA, Prudic, J, Devanand, DP, et al.Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. N Engl J Med. 1993;328:839–846.CrossRefGoogle ScholarPubMed
6.Nobler, MS, Sackeim, HA, Prohovnik, I, et al: Regional cerebral blood flow in mood disorders: Treatment and clinical response. Arch Gen Psychiatry. 1994;51:884–897.CrossRefGoogle ScholarPubMed
7.Lisanby, SH, Luber, BM, Finck, D, et al.Magnetic stimulation therapy: a novel convulsive technique. Biol Psychiatry. 1999: Abstract.Google Scholar
8.George, MS, Belmaker, RH. Transcranial Magnetic Stimulation in Neuropsychiatry. Washington, DC: American Psychiatric Press; 2000.Google Scholar
9.George, MS, Lisanby, SH, Sackeim, HA. Transcranial magnetic stimulation: applications in neuropsychiatry. Arch Gen Psychiatry. 1999;56:300–311.CrossRefGoogle ScholarPubMed
10.George, MS, Wassermann, EM, Post, RM. Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century. J Neuropsychiatry Clin Neurosci. 1996;8:373–382.Google Scholar
11.George, MS, Wassermann, EM, Williams, W, et al.Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996;8:172–180.Google ScholarPubMed
12.Pascual-Leone, A, Catala, MD, Pascual, AP. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood. Neurology. 1996;46:499–502.CrossRefGoogle ScholarPubMed
13.Martin, JD, George, MS, Greenberg, BD, et al.Mood effects of prefrontal repetitive high-frequency TMS in healthy volunteers. CNS Spectrums. 1997;2:53–68.CrossRefGoogle Scholar
14.George, MS, Nahas, Z, Bohning, DE, et al.Transcranial magnetic stimulation and neuroimaging. In: MS, George, RH, Belmaker, eds. Transcranial Magnetic Stimulation in Neuropsychiatry. Washington, DC: American Psychiatric Press; 2000:253–268.Google Scholar
15.Greenberg, BD, George, MS, Dealing, J, et al.Effect of pre-frontal repetitive transcranial magnetic stimulation (rTMS) in obsessive compulsive disorder: a preliminary study. Am J Psychiatry. 1997;154:867–869.Google Scholar
16.Karp, BI, Wassermann, EM, Porter, S, et al: Transcranial Magnetic Stimulation Acutely Decrease Motor Tics. Neurol 1997;48:A397: Abstract.Google Scholar
17.Ziemann, U, Paulus, W, Rothenberger, A. Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulation. Am J Psychiatry. 1997;154:1277–1284.Google ScholarPubMed
18.Ziemann, U, Hallett, M: Basic Neurophysiological Studies with TMS. In: MS, George, RH, Belmaker, Eds. Transcranial Magnetic Stimulation in Neuropsychiatry. Washington, DC: American Psychiatric Press; 2000:45–98.Google Scholar
19.Greenberg, BD, Ziemann, U, Harmon, A, et al.Reduced intracortical inhibition in obsessive-compulsive disorder on transcranial magnetic stimulation. Lancet. 1998;352:881–882.CrossRefGoogle Scholar
20.Greenberg, BD, Ziemann, U, Cora-Locatelli, G, et al.Altered cortical excitability in obsessive-compulsive disorder. Neurology. 2000;54:142–147.CrossRefGoogle ScholarPubMed
21.Rothenberger, A, Moll, GH, Wischer, S, et al.Deficient motor inhibition in children with tic disorder: evidence from transcranial magnetic stimulation. Third International Scientific Symposium on Tourette Syndrome. New York, NY: Aug 1999; abstract.Google Scholar
22.Schachter, SC, Saper, CB. Vagus nerve stimulation. Epilepsia. 1998;39:677–686.CrossRefGoogle ScholarPubMed
23.George, MS, Sackeim, HA, Rush, AJ, et al.Vagus nerve stimulation: a new tool for brain research and therapy. Biol Psychiatry. 2000;47:287–295.CrossRefGoogle ScholarPubMed
24.Zabara, J.Inhibition of experimental seizures in canines by repetitive vagal stimulation. Epilepsia. 1992;33:1005–1012.CrossRefGoogle ScholarPubMed
25.The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology. 1995;224:230.Google Scholar
26.Okuma, T, Kishimoto, A, Inoue, K, et al: Anti-manic and prophylactic effects of carbamazepine (tegretol) on manic depressive psychosis. Folia Psychiatrica Neurologica. 1973; 27:283–297.Google ScholarPubMed
27.Ballenger, JC, Post, RM. Theraputic effects of carbamazepine in affective illness: a preliminary report. Comm Psychopharmacol. 1978;2:159–175.Google Scholar
28.Youssef, HA, Waddington, JL. Primitive (developmental) reflexes and diffuse cerebral dysfunction in schizophrenia and bipolar affective disorder: overrepresentation in patients with tardive dyskinesia. Biol Psychiatry. 1988; 23:791–796.CrossRefGoogle ScholarPubMed
29.Swann, AC, Bowden, CL, Morris, D, et al.Depression during mania. Treatment response to lithium or divalproex. Arch Gen Psychiatry. 1997;54:37–42.CrossRefGoogle ScholarPubMed
30.Fatemi, SH, Rapport, DJ, Calabrese, JR, et al.Lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry. 1997; 58:522–527.CrossRefGoogle ScholarPubMed
31.Rush, AJ, George, MS, Sackeim, HA, et al.Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry. 2000; 47:276–286.CrossRefGoogle ScholarPubMed
32.Heath, RG. Pleasure response of human subjects to direct stimulation of the brain: physiologic and psychodynamic considerations. In: RG, Heath, ed. The Role of Pleasure in Behavior. New York, NY: Hoeber; 1964:219–243.Google Scholar
33.Heath, RG, Dempsey, CW, Fontana, CJ, et al.Cerebellar stimulation: effects on septal region, hippocampus, and amygdala of cats and rats. Biol Psychiatry. 1978;13:501–529.Google ScholarPubMed
34.Heath, RG, Mickle, WA: Evaluation of seven years experience with depth electrode studies in human patients. In: ER, Ramey, O'Doherty, D, eds. Electrical Studies of the Unanesthetized Brain. New York, NY: Hoeber, 1960:14–247.Google Scholar
35.Limousin, P, Krack, P, Pollak, P, et al.Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med. 1998;339:1105–1111.CrossRefGoogle ScholarPubMed
36.Damier, P. The stimulation of deep cerebral structures in the treatment of Parkinson's disease. Eur Neuropsychopharmacol. 1998;8:abstract.CrossRefGoogle Scholar
37.Nuttin, B, Cosyns, P, Demeulemeester, H, et al.Electrical stimulation on anterior limbs of internal capsule in patients with obsessive-compulsive disorder. Lancet. 1999;354:1526.CrossRefGoogle Scholar
38.George, MS, Melvin, JA, Kellner, CH. Obsessive-compulsive symptoms in neurologic disease: a review. Behav Neurol. 1992; 5:19–30.CrossRefGoogle ScholarPubMed
39.George, MS. Obsessive-compulsive disorder. Int Clin Psychopharmacol. 1991;6:57s–68s.CrossRefGoogle ScholarPubMed