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Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study

  • Konstantinos N. Fountoulakis (a1), Elena Dragioti (a2) (a3), Antonis T. Theofilidis (a1), Tobias Wiklund (a2) (a3), Xenofon Atmatzidis (a2) (a3), Ioannis Nimatoudis (a1), Erik Thys (a4), Martien Wampers (a4) (a5), Luchezar Hranov (a6), Trayana Hristova (a6), Daniil Aptalidis (a6), Roumen Milev (a7), Felicia Iftene (a7), Filip Spaniel (a8), Pavel Knytl (a8), Petra Furstova (a8), Tiina From (a9), Henry Karlsson (a9), Maija Walta (a9), Raimo K.R. Salokangas (a9), Jean-Michel Azorin (a10) (a11), Justine Bouniard (a10) (a11), Julie Montant (a10) (a11), Georg Juckel (a12), Ida S. Haussleiter (a12), Athanasios Douzenis (a13), Ioannis Michopoulos (a13), Panagiotis Ferentinos (a13), Nikolaos Smyrnis (a14), Leonidas Mantonakis (a14), Zsófia Nemes (a15), Xenia Gonda (a16), Dora Vajda (a16), Anita Juhasz (a16), Amresh Shrivastava (a17), John Waddington (a18), Maurizio Pompili (a19), Anna Comparelli (a19), Valentina Corigliano (a19), Elmars Rancans (a20), Alvydas Navickas (a21) (a22) (a23), Jan Hilbig (a21) (a22) (a23), Laurynas Bukelskis (a21) (a22) (a23), Lidija I. Stevovic (a24) (a25) (a26), Sanja Vodopic (a24) (a25) (a26), Oluyomi Esan (a27), Oluremi Oladele (a27), Christopher Osunbote (a27), Janusz Κ. Rybakowski (a28), Pawel Wojciak (a28), Klaudia Domowicz (a28), Maria L. Figueira (a29), Ludgero Linhares (a29), Joana Crawford (a29), Anca-Livia Panfil (a30), Daria Smirnova (a31), Olga Izmailova (a31), Dusica Lecic-Tosevski (a32) (a33), Henk Temmingh (a34), Fleur Howells (a34), Julio Bobes (a35), Maria P. Garcia-Portilla (a35), Leticia García-Alvarez (a35), Gamze Erzin (a36), Hasan Karadağ (a36), Avinash De Sousa (a37), Anuja Bendre (a37), Cyril Hoschl (a8), Cristina Bredicean (a38), Ion Papava (a38), Olivera Vukovic (a39), Bojana Pejuskovic (a40), Vincent Russell (a40), Loukas Athanasiadis (a41), Anastasia Konsta (a41), Dan Stein (a42), Michael Berk (a43) (a44) (a45) (a46), Olivia Dean (a43) (a44) (a45) (a46), Rajiv Tandon (a47), Siegfried Kasper (a48) and Marc De Hert (a4) (a5) (a49)...

Abstract

Background.

The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.

Methods.

Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.

Results.

The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.

Conclusions.

The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct “cores” of schizophrenia, the “Positive” and the “Negative,” while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.

Copyright

Corresponding author

Konstantinos N. Fountoulakis, Email: kfount@med.auth.gr

References

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Keywords

Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study

  • Konstantinos N. Fountoulakis (a1), Elena Dragioti (a2) (a3), Antonis T. Theofilidis (a1), Tobias Wiklund (a2) (a3), Xenofon Atmatzidis (a2) (a3), Ioannis Nimatoudis (a1), Erik Thys (a4), Martien Wampers (a4) (a5), Luchezar Hranov (a6), Trayana Hristova (a6), Daniil Aptalidis (a6), Roumen Milev (a7), Felicia Iftene (a7), Filip Spaniel (a8), Pavel Knytl (a8), Petra Furstova (a8), Tiina From (a9), Henry Karlsson (a9), Maija Walta (a9), Raimo K.R. Salokangas (a9), Jean-Michel Azorin (a10) (a11), Justine Bouniard (a10) (a11), Julie Montant (a10) (a11), Georg Juckel (a12), Ida S. Haussleiter (a12), Athanasios Douzenis (a13), Ioannis Michopoulos (a13), Panagiotis Ferentinos (a13), Nikolaos Smyrnis (a14), Leonidas Mantonakis (a14), Zsófia Nemes (a15), Xenia Gonda (a16), Dora Vajda (a16), Anita Juhasz (a16), Amresh Shrivastava (a17), John Waddington (a18), Maurizio Pompili (a19), Anna Comparelli (a19), Valentina Corigliano (a19), Elmars Rancans (a20), Alvydas Navickas (a21) (a22) (a23), Jan Hilbig (a21) (a22) (a23), Laurynas Bukelskis (a21) (a22) (a23), Lidija I. Stevovic (a24) (a25) (a26), Sanja Vodopic (a24) (a25) (a26), Oluyomi Esan (a27), Oluremi Oladele (a27), Christopher Osunbote (a27), Janusz Κ. Rybakowski (a28), Pawel Wojciak (a28), Klaudia Domowicz (a28), Maria L. Figueira (a29), Ludgero Linhares (a29), Joana Crawford (a29), Anca-Livia Panfil (a30), Daria Smirnova (a31), Olga Izmailova (a31), Dusica Lecic-Tosevski (a32) (a33), Henk Temmingh (a34), Fleur Howells (a34), Julio Bobes (a35), Maria P. Garcia-Portilla (a35), Leticia García-Alvarez (a35), Gamze Erzin (a36), Hasan Karadağ (a36), Avinash De Sousa (a37), Anuja Bendre (a37), Cyril Hoschl (a8), Cristina Bredicean (a38), Ion Papava (a38), Olivera Vukovic (a39), Bojana Pejuskovic (a40), Vincent Russell (a40), Loukas Athanasiadis (a41), Anastasia Konsta (a41), Dan Stein (a42), Michael Berk (a43) (a44) (a45) (a46), Olivia Dean (a43) (a44) (a45) (a46), Rajiv Tandon (a47), Siegfried Kasper (a48) and Marc De Hert (a4) (a5) (a49)...

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