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Delirium Following Ingestion of Marijuana Present in Chocolate Cookies

Published online by Cambridge University Press:  07 November 2014

Charles André ,
Jorge A. Jaber-Filho ,
Rafael M.A. Bento ,
Lúcia M.P. Damasceno  and
Francisco R. Aquino-Neto
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Abstract

Objective: To describe a case of marijuanainduced delirium and the techniques used to detect psychoactive agents and metabolites in urine.

Methods: A case of delirium following involuntary ingestion of cannabis is described. A urine sample was analyzed applying various chemical procedures, using high-resolution gas chromatography coupled with mass spectrometry technique. 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid was quantified by the methodology for steroids and cannabis.

Results: A 26-year-old man was hospitalized with severe agitation and psychotic behavior 36 hours after suspected involuntary ingestion of cannabis contained in a brigadeiro, a typical Brazilian cookie, consumed during a party. Treatment with neuroleptics resulted in complete regression of the symptoms over 2 weeks. The urine sample revealed marijuana ingestion, demonstrated by the presence of its metabolite, 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in

Conclusion: Severe delirium can follow oral ingestion of cannabis integrated into homemade cookies.

Type
Original Research
Information
CNS Spectrums , Volume 11 , Issue 4 , April 2006 , pp. 262 - 264
Copyright
Copyright © Cambridge University Press 2006

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References

REFERENCES

1.Degenhardt, L, Hall, W, Lynskey, M. Testing hypotheses about the relation between cannabis use and psychosis. Drug Alcohol Depend. 2003;71:37–48.CrossRefGoogle ScholarPubMed
2.Donike, M. Steroid profile in Cologne. In: Schänzer, W, Geyer, H, Gotzmann, A, Mareck-Engelke, U, eds. Proceedings 10th Cologne Workshop on Dope Analysis [German]. KöIn: Sport und Buch Strauβ. 1993;47:68.Google Scholar
3.Gordon, E, Devinsky, O. Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy. Epilepsia. 2001;42:1266–1272.CrossRefGoogle ScholarPubMed
4.Huestis, MA, Cone, EJ. Urinary excretion half-life of 11-nor-9-carboxy-delta9-tetra-hydrocannabinol in humans. Ther Drug Monit 1998;20:570–576.CrossRefGoogle ScholarPubMed
5.Imade, AG, Ebie, JC. A retrospective study of symptom patterns of cannabis-induced psychosis. Acta Psychiatr Scand. 1991;83:134–136.CrossRefGoogle ScholarPubMed
6.Palsson, A, Thulin, SO, Tunving, K. Cannabis psychosis in South Sweden. Acta Psychiatr Scand. 1982;66:311–321.Google Scholar
7.Smith-Kielland, A, Skuterud, B, Morland, J. Urinary excretion of 11-nor-9-carboxydelta9-tetrahydrocannabinol and cannabinoids in frequent and infrequent drug users. J Anal Toxicol. 1999;23:323–332.CrossRefGoogle ScholarPubMed
8.Solans, A, Carnicero, M, de La Torre, R, Segura, J. Comprehensive screening procedure for detection of stimulants, narcotics, adrenergics drugs, and their metabolites in human urine. J Anal Toxicol. 1995;19:104–114.Google Scholar
9.Thacore, VR, Shukla, SR. Cannabis psychosis and paranoid schizophrenia. Arch Gen Psychiatry. 1976;33:383–386.Google Scholar
10.van Os, J, Bak, M, Hanssen, M, Bijl, RV, de Graaf, R, Verdoux, H. Cannabis use and psychosis: a longitudinal population-based study. Am J Epidemiol. 2002;156:319–327.Google Scholar
11.Zachariah, SB. Stroke after heavy marijuana smoking. Stroke. 1991;22:406–409.Google Scholar
12.Grech, A, Van Os, J, Jones, PB, Lewis, SW, Murray, RM. Cannabis use and outcome of recent onset psychosis. Eur Psychiatry. 2005;20:349–353.CrossRefGoogle ScholarPubMed