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Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis

Published online by Cambridge University Press:  14 June 2021

Satyajit Mohite ,
Haitham Salem ,
Thiago Cordeiro ,
Jonika Tannous ,
Benson Mwangi ,
Sudhakar Selvaraj ,
Jair C. Soares ,
Marsal Sanches Open the ORCID record for Marsal Sanches [Opens in a new window]  and
Antonio L. Teixeira
Satyajit Mohite
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA Department of Psychiatry and Psychology, Mayo Clinic Health System, Mankato, Minnesota, USA
Haitham Salem
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Thiago Cordeiro
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Jonika Tannous
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Benson Mwangi
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Sudhakar Selvaraj
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Jair C. Soares
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Marsal Sanches*
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
Antonio L. Teixeira
Affiliation:
Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, Texas, USA
*
*Author for correspondence: Marsal Sanches, MD, PhD Email: Marsal.Sanches@uth.tmc.edu
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Abstract

Background

Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain changes in euthymic patients with BD.

Methods

Euthymic patients with BD (n = 21) and healthy controls (n = 22) were enrolled in this exploratory study. Blood samples were collected on the same day of clinical assessment and neuroimaging. Cytokines were measured through cytometric bead array method. Neuroimaging data were acquired using a sagittal three-dimensional magnetic resonance imaging T1-weighted fast field echo sequence and was processed using FreeSurfer.

Results

Compared to controls, BD patients had significantly lower volumes in the cingulate, medial-orbitofrontal (MOF) and parahippocampal regions. We found a negative correlation between right MOF volume and interferon-gamma levels (β = −0.431, P = .049) and a positive correlation between interleukin-10 levels and left posterior cingulate volume (β = 0.457, P = .048).

Conclusion

Our results support the involvement of inflammatory pathways in structural brain changes in BD.

Keywords

Bipolar disorderneuroinflammationneuroimaginggray matterprefrontal cortexaccelerated aging
Type
Original Research
Information
CNS Spectrums , Volume 27 , Issue 5 , October 2022 , pp. 639 - 644
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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