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Comorbidity with Axis I Anxiety Disorders in Remitted Psychotic Patients 1 Year After Hospitalization

  • Antonio Ciapparelli, Rosemma Paggini, Donatella Marazziti, Claudia Carmassi, Maria Bianchi, Claudia Taponecco, Giorgio Consoli, Valentina Lombardi, Gabriele Massimetti and Liliana Dell'Osso...

Abstract

Introduction

Comorbid anxiety disorders are frequently encountered in psychoses and mainly assessed during the hospitalization.

Methods

Comorbidity was investigated in 98 patients with schizophrenia, schizoaffective, or bipolar disorder, previously hospitalized for psychotic symptoms. Assessments, including Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Brief Psychiatric Rating Scale, and Clinical Global Impressions Scale, were performed during hospitalization (t0) and subsequently in a phase of remission (t1). Comorbidity was assessed at t1 only.

Results

One or more comorbid anxiety diagnoses were made in 46 (46.9%) patients. Of these, 15 (32.6%) received multiple anxiety diagnoses, while 31 (67.4%) single anxiety diagnoses. Schizophrenic patients had a rate of social anxiety disorder (SAD) higher (P<.05) than the others. Patients assessed with panic disorder or with obsessive-compulsive disorder at t1 showed significantly greater severity of illness at t0; patients with SAD demonstrated greater severity at t1. No significant differences in the rates of individual anxiety disorders were found in patients treated with typical or atypical antipsychotics or with both.

Conclusion

Anxiety disorders, particularly obsessive-compulsive disorder, panic disorder and SAD, seem to be frequently comorbid in remitted psychotic patients; SAD would be more prevalent in schizophrenia and might negatively impact the course of the illness.

Copyright

Corresponding author

Please direct all correspondence to: Rosemma Paggini, MD, University of Pisa, Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, via Roma 67, 1-56100 Pisa, Italy; Tel: 39 050 835423, Fax: 39 050 21581; E-mail: rosemma_paggini@yahoo.it.

References

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Comorbidity with Axis I Anxiety Disorders in Remitted Psychotic Patients 1 Year After Hospitalization

  • Antonio Ciapparelli, Rosemma Paggini, Donatella Marazziti, Claudia Carmassi, Maria Bianchi, Claudia Taponecco, Giorgio Consoli, Valentina Lombardi, Gabriele Massimetti and Liliana Dell'Osso...

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