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Brain Hemispheric Organization, Anxiety, and Psychoses

  • Silvana Galderisi, Armida Mucci and Mario Maj


Abnormalities of brain hemispheric organization have been found in a variety of psychiatric disorders. Despite the great amount of data collected and the number of theoretical models elaborated, the role of these abnormalities in the pathogenesis of these disorders remains controversial. This article briefly reviews current concepts of hemispheric functioning, discusses the role of abnormalities of brain hemispheric organization in schizophrenia and in two anxiety disorders (panic disorder and obsessive-compulsive disorder), and outlines a developmental perspective that accounts for the observed abnormalities.



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1.Otto, MW. Normal and abnormal information processing. Psychiatr Clin North Am. 1992;15:825848.
2.Gruzelier, JH. Syndromes of schizophrenia and schizotypy, hemispheric imbalance and sex differences: implications for developmental psychopathology. Int J Psychophysiol. 1994;18:167178.
3.Lohr, JB, Caligiuri, MP. Lateralized hemispheric dysfunction in the major psychotic disorders: historical perspectives and findings from a study of motor asymmetry in older patients. Schizophr Res. 1997;27:191198.
4.Coplan, JD, Lydiard, RB. Brain circuits in panic disorder. Biol Psychiatry. 1998;44:12641276.
5.Cohen, J. Theoretical interpretations of lateral asymmetries. In: Beaumont, JG, ed. Divided Visual Field Studies of Cerebral Organization. London, England: Academic Press; 1982:87111.
6.Bradshaw, JL, Nettleton, NC. The nature of hemispheric specialization in man. Behav Brain Sci. 1981;4:5191.
7.LeMay, M. Radiological, developmental and fossil asymmetries. In: Geschwind, N, Galaburda, AlM, eds. Cerebral Dominance. The Biological Foundations. Cambridge, Mass: Harvard University Press; 1984:2642.
8.Scheibel, AB. A dendritic correlate of human speech. In: Geschwind, N, Galaburda, AM, eds. Cerebral Dominance. The Biological Foundations. Cambridge, Mass: Harvard University Press; 1984:4352.
9.Szelag, E, Wasilewski, R, Fersten, E. Hemispheric differences in the perception of words and faces in deaf and hearing children. Scand J Psychol. 1992;33:111.
10.Szelag, E, Wasilewski, R. The effect of congenital deafness on cerebral asymetry in the perception of emotional and non-emotional faces. Acta Psychol. 1992;79:4557.
11.Grabowska, A, Herman, A, Nowicka, A, et al.Individual differences in the functional asymmetry of the human brain. Acta Neurobiol Exp. 1994;54:155162.
12.Levy, J. Psychological implications of bilateral asymmetry. In: Dimond, S, Beaumont, JG, eds. Hemisphere Function in the Human Brain. London, England: Paul Elek; 1974.
13.Levy, J, Gur, RC. Individual differences in psychoneurological organization. In: Herron, J, ed. The Neuropsychology of Left-handedness. New York, NY: Academic Press; 1980.
14.Semmes, J. Hemispheric specialization: a possible clue to mechanism. Neuropsychologia. 1968;6:1126.
15.Burgess, C, Simpson, GB. Cerebral hemispheric mechanisms in the retrieval of ambiguous word meanings. Brain Lang. 1988;33:86103.
16.Safer, MA, Leventhal, H. Ear differences in evaluating emotional tones of voice and verbal content. J Exp Psychol Hum Percept Perform. 1977;3:7582.
17.Tucker, DM, Williamson, PA. Asymmetric neural control systems in human self-regulation. Psychol Rev. 1984;91:185215.
18.Tucker, DM. Developing emotions and cortical networks. In: Gunner, MR, Nelson, CA, eds. Minnesota Symposium on Child Psychology. Vol 24. Hillsdale, NJ: Erlbaum; 1992:75128.
19.Milner, B. Some cognitive effects of frontal-lobe lesions in man. Philos Trans R Soc Lond B Biol Sci. 1982;298:211226.
20.Milner, B, Petrides, M. Behavioural effects of frontal lobe lesions in man. Trends Neurosci. 1984;7:403407.
21.Goldberg, E, Podell, K. Hemispheric specialization, cognitive novelty, and the frontal lobes. In: Jasper, H, Goldman-Rakic, PS, Riggio, S, eds. Epilepsy and the Functional Anatomy of the Frontal Lobe. New York, NY: Raven Press; 1994.
22.Flor-Henry, P. Lateralized temporo-limbic dysfunction and psychopathology. Ann N Y Acad Sci. 1976;280:777795.
23.Flor-Henry, P. Laterality, shifts of cerebral dominance, sinistrality and psychosis. In: Gruzelier, JH, Flor-Henry, P, eds. Hemisphere Asymmetries of Function in Psychopathology. Amsterdam, The Netherlands: Elsevier, 1979:319.
24.Galderisi, S, Maj, M, Mucci, A, et al.Lateralization patterns of verbal stimuli processing assessed by reaction time and event-related potentials in schizophrenic patients. Int J Psychophysiol. 1988;6:167176.
25.Crow, TJ, Ball, J, Bloom, SR, et al.Schizophrenia as an anomaly of development of cerebral, asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease. Arch Gen Psychiatry. 1989;46:11451150.
26.Gur, RE, Resnick, SM, Gur, RC. Laterality and frontality of cerebral blood flow and metabolism in schizophrenia: relationship to symptom specificity. Psychiatry Res. 1989;27:325334.
27.Kemali, D, Galderisi, S, Maj, M, et al.Lateralization patterns of event-related potential and performance indices in schizophrenia: relationship to clinical state and neuroleptic treatment. Int J Psychophysiol. 1991;10:225230.
28.Lohr, JB, Caligiuri, MP. Motor asymmetry, a neurobiologic abnormality in the major psychoses. Psychiatry Res. 1995;57:279282.
29.Boklage, CE. Schizophrenia, brain asymmetry development and twinning: cellular relationship with etiological and possibly prognostic implications. Biol Psychiatry. 1977;12:1935.
30.Gur, RE. Motoric laterality in schizophrenia. Arch Gen Psychiatry. 1977;34:3337.
31.Gur, RE. Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia. J Abnorm Psychol. 1978;87:226238.
32.Bracha, HS. Asymmetric rotational (circling) behavior, a dopamine-related asymmetry: preliminary findings in unmedicated and never-medicated schizophrenic patients. Biol Psychiatry. 1987;22:9951002.
33.Lerner, J, Nachson, I, Carmon, A. Responses of paranoid and nonparanoid schizophrenia in a dichotic listening task. J New Ment Dis. 1977;164:247252.
34.Lishman, W, Toone, B, Colbourn, C, et al.Dichotic listening in psychotic patients. Br J Psychiatry. 1978;132:333341.
35.Galderisi, S, Mucci, A, Maj, M, Kemali, D. Abnormalities of hemispheric lateralization in schizophrenic patients: a study using event-related potentials. New Trends Exp Clin Psychiatr. 1994;10:2529.
36.Wexler, BE, Giller, EL, Southwick, S. Cerebral laterality, symptoms, and diagnosis in psychotic patients. Biol Psychiatry. 1991;29:103116.
37.Posner, MI, Early, TS, Reiman, E, et al.Asymmetries in hemispheric control of attention in schizophrenia. Arch Gen Psychiatry. 1988;45:814821.
38.Early, TS, Posner, I, Reiman, EM, et al.Hyperactivity of the left striato-pallidal projection: part I. lower level theory. Psychiatr Dev. 1989;2:85108.
39.Wigal, SB, Potkin, SG, Raja, P, et al.Asymmetries in attention filtering in left and right visual fields in schizophrenic patients. Schizophr Res. 1991;27:396.
40.Luchins, DJ, Weinberger, DR, Wyatt, RJ. Schizophrenia: evidence for a subgroup with reversed cerebral asymmetry. Arch Gen Psychiatry. 1979;36:13091311.
41.Luchins, DJ, Weinberger, DR, Wyatt, RJ. Schizophrenia and cerebral asymmetry detected by computed tomography. Am J Psychiatry. 1982;139:753757.
42.Barta, PE, Pearlson, GD, Powers, RE, et al.Auditory hallucinations and smaller superior temporal gyrus volume in schizophrenia. Am J Psychiatry. 1990;147:14571462.
43.Rossi, A, Stratta, P, Di Michele, V, et al.Temporal lobe structure by magnetic resonance in bipolar affective disorders and schizophrenia. J Affect Disord. 1991;21:1922.
44.Shenton, M, Kikinis, R, Jolsz, FA, et al.Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. N Engl J Med. 1992;327:604612.
45.Falkai, P, Bogerts, B, Benno, G, et al.Loss of Sylvian fissure asymmetry in schizophrenia: a quantitative postmortem study. Schizophr Res. 1992;7:2332.
46.DeLisi, LE, Hoff, AL, Neale, C, et al.Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophr Res. 1994;12:1928.
47.Bullmore, E, Brammer, M, Harvey, I, et al.Cerebral hemispheric asymmetry revisited: effects of handedness, gender and schizophrenia measured by radius of gyration in magnetic resonance images. Psychol Med. 1995;25:349363.
48.Maj, M, Galderisi, S, Conforti, R, et al.Gross reversal of brain parieto-occipital asymmetry in a case of DSM-IV simple schizophrenia. Schizophr Res. 1995;14:265266.
49.Petty, RG, Barta, PE, Pearlson, GD, et al.Reversal of asymmetry of the planum temporale in schizophrenia. Am J Psychiatry. 1995;152:715721.
50.Tiihonen, J, Katila, H, Pekkonen, E, et al.Reversal of cerebral asymmetry in schizophrenia measured with magnetoencephalography. Schizophr Res. 1998;30:209219.
51.Faux, SF, Shenton, ME, McCarley, RW, et al.Differentiation of schizophrenics and normal controls is enhanced by the Goodin subtraction procedure. Int J Neurosci. 1988;39:117135.
52.Holinger, DP, Faux, SF, Shenton, ME, et al.Reversed temporal region asymmetries of P300 topography in left- and right-handed schizophrenic subjects. Electroencephalogr Clin Neurophysiol. 1992;84:532537.
53.McCarley, RW, Faux, SF, Shenton, ME, et al.Is there P300 asymmetry in schizophrenia? Arch Gen Psychiatry. 1991;48:380381.
54.McCarley, RW, Shenton, ME, O'Donnel, BF, et al.Auditory P300 abnormalities and left posterior superior temporal gyrus volume reduction in schizophrenia. Arch Gen Psychiatry. 1993;50:190197.
55.Strik, WK, Dierks, T, Franzek, E, et al.P300 asymmetries in schizophrenia revisited with reference-independent methods. Psychiatry Res. 1994;55:153166.
56.Rockstroh, B, Clementz, BA, Pantev, C, et al.Failure of dominant left-hemispheric activation to right-ear stimulation in schizophrenia. Neuroreport. 1998;9:38193822.
57.Cutting, J. The Psychology of Schizophrenia. Edinburgh, Scotland: Churchill Livingstone; 1985.
58.Cutting, J. The Right Cerebral Hemisphere and Psychiatric Disorders. Oxford, England: Oxford University Press; 1990.
59.Pfefferbaum, A, Ford, JM, White, PM, et al.P3 in schizophrenia is affected by stimulus modality, response requirements, medication and negative symptoms. Arch Gen Psychiatry. 1989;46:10351044.
60.Persaud, R, Cutting, J. Lateralized anomalous perceptual experiences in schizophrenia. Psychopathology. 1991;24:365368.
61.Cutting, J. The role of right hemisphere dysfunction in psychiatric disorders. Br J Psychiatry. 1992;160:583588.
62.Cutting, J. Evidence for right hemisphere dysfunction in schizophrenia. In: David, AS, Cutting, J, eds. The Neuropsychology of Schizophrenia. Hove, England: Lawrence Erlbaum Associates; 1994:231242.
63.Torrey, EF, Ragland, JD, Gold, JM, et al.Handedness in twins with schizophrenia: was Boklage correct? Schizophr Res. 1993;9:8385.
64.David, AS, Cutting, JC. The Neuropsychology of Schizophrenia. Hove, England: Lawrence Erlbaum Associates Ltd; 1994.
65.Sakuma, M, Hoff, AL, DeLisi, LE. Functional laterality and cognitive ability. Schizophr Res. 1996;18:213214.
66.Cowell, PE, Fitch, RH, Denenberg, VH. Laterality in animals: relevance to schizophrenia. Schizophr Bull. 1999;25:4162.
67.Ragland, JD, Gur, RE, Klimas, BC, et al.Neuropsychological laterality indices of schizophrenia: interactions with gender. Schizophr Bull. 1999;25:7989.
68.Jerussi, TP, Taylor, CA. Bilateral asymmetry in striatal dopamine metabolism: implications for pharmacotherapy of schizophrenia. Brain Res. 1982;246:7175.
69.Gruzelier, JH. Functional neuropsychophysiological asymmetry in schizophrenia: a review and reorientation. Schizophr Bull. 1999;25:91120.
70.Magara, F, Mucci, A, Galderisi, S, et al.Sex differences in hemispheric asymmetries in schizophrenic patients and normal controls. Neurosci Lett. 1990;39:S132.
71.Galderisi, S. The influence of gender on cognitive event-related potentials in schizophrenics and healthy controls. J Psychophysiol. 1995;9:85.
72.Galderisi, S, Mucci, A, Mignone, ML, et al.Lateralizzazione emisferica ed eterogeneità legata al sesso nella schizofrenia. Rivista di Psichiatria. 1995;30:121127.
73.Galderisi, S, Maj, M, Mignone, ML, et al.Brain functional asymmetries, gender and schizophrenia. Curr Opin Psychiatry. 1999;suppl 1:68.
74.Cowell, PE, Kostianovsky, DJ, Gur, RC, et al.Sex differences in neuroanatomical and clinical correlations in schizophrenia. Am J Psychiatry. 1996;153:799805.
75.Lewine, RRJ, Walker, EF, Shurett, R, et al.Sex differences in neuropsychological functioning among schizophrenic patients. Am J Psychiatry. 1996;153:11781184.
76.Reite, M, Sheeder, J, Teale, P, et al.Magnetic source imaging evidence of sex differences in cerebral lateralization in schizophrenia. Arch Gen Psychiatry. 1997;54:433440.
77.Lewine, RJ. Sex differences in schizophrenia–timing or sub-types? Psychol Bull. 1981;90:432444.
78.Seeman, MV. Current outcome in schizophrenia: women vs men. Acta Psychiatr Scand. 1986;73:609617.
79.Goldstein, JM, Tsuang, MT. Gender and schizophrenia: an introduction and synthesis of findings. Schizophr Bull. 1990;10:179183.
80.Flor-Henry, P. Influence of gender in schizophrenia as related to other psychopathological syndromes. Schizophr Bull. 1990;16:211227.
81.Hafner, H, Maurer, K, Loffler, W, et al.The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry. 1993;162:8086.
82.Gur, RE, Petty, RG, Turetsky, BI, et al.Schizophrenia throughout life: sex differences in severity and profile of symptoms. Schizophr Res. 1996;21:112.
83.Heidrich, A, Strik, W. Auditory P300 topography and neuropsychological test performance: evidence for left hemispheric dysfunction in schizophrenia. Biol Psychiatry. 1997;41:327335.
84.Gruzelier, JH. Hemispheric imbalance: syndromes of schizophrenia, premorbid personality, and neurodevelopmental influences. In: Steinhauer, S, Gruzelier, JH, Zubin, J, et al, eds. Neuropsychology, Psychophysiology and Information Processing. Vol 5. Amsterdam, The Netherlands: Elsevier; 1991:599650.
85.Gruzelier, JH, Richardson, AJ. Patterns of cognitive asymmetry and psychosis proneness. Int J Psychophysiol. 1994;18:217225.
86.Gruzelier, JH, Burgess, A, Stygall, J, et al.Patterns of cognitive asymmetry and syndromes of schizotypal personality. Psychiatry Res. 1995;56:7179.
87.Kemali, D, Maj, M, Galderisi, S, et al.Conditional associative learning in drug-free schizophrenic patients. Neuropsychobiology. 1987;17:3034.
88.Galderisi, S, Mucci, A, Mignone, ML, et al.Hemispheric asymmetry and psychopathological dimensions in drug-free patients with schizophrenia. Int J Psychophysiol. 1999;34:293301.
89.Bilder, RM, Lieberman, JA, Kim, Y, et al.Methylphenidate and neuroleptic effects on oral word production in schizophrenia. Neuropsychiatr Neuropsychol Behav Neurol. 1992;5:262.
90.Gruzelier, JH. Hemispheric imbalances in schizophrenia. Int J Psychophysiol. 1984;1:227240.
91.Gur, RE. Is Schizophrenia a lateralized disorder? Editor's introduction. Schizophr Bull. 1999;25:79.
92.Tamlyn, D, McKenna, PJ, Mortimer, AM, et al.Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character. Psychol Med. 1992;22:101115.
93.Duffy, L, O'Carrol, R. Memory impairment in schizophrenia–a comparison with that observed in the Alcoholic Korsakoff Syndrome. Psychol Med. 1994;24:155165.
94.Sullivan, EV, Shear, PK, Zipursky, RB, et al.A deficit profile of executive, memory, and motor functions in schizophrenia. Biol Psychiatry. 1994;36:641653.
95.Grillon, C, Ameli, R, Goddard, A, et al.Baseline and fear-potentiated startle in panic disorder patients. Biol Psychiatry. 1994;35:431439.
96.Edlund, MJ, Swann, AC, Clothier, J. Patients with panic attacks and abnormal EEG results. Am J Psychiatry. 1987;144:508509.
97.Abraham, H, Duffy, F. Computed EEG abnormalities in panic disorder with and without premorbid drug abuse. Biol Psychiatry. 1991;29:687690.
98.Dantendorfer, K, Prayer, D, Kramer, J, et al.High frequency of EEG and MRI brain abnormalities in panic disorder. Psychiatry Res. 1996;68:4153.
99.Lucas, JA, Telch, MJ, Bigler, ED. Memory functioning in panic disorder: a neuropsychological perspective. J Anxiety Dis. 1991;51:20.
100.Asmundson, GJG, Stein, MB, Larsen, DK, et al.Neurocognitive function in panic disorder and social phobia patients. Anxiety. 1995;1:201207.
101.Roth, M, Harper, M. Temporal lobe epilepsy and the phobic anxiety-depersonalization syndrome. Part II: practical and theoretical considerations. Compr Psychiat. 1962;3:215226.
102.McLachlan, RS, Blume, WT. Isolated fear in complex partial status epilepticus. Ann Neurol. 1980;8:639641.
103.Wall, M, Tuchman, M, Mielke, D. Panic attacks and temporal lobe seizures associated with a right temporal lobe arteriovenous malformation. J Clin Psychiatry. 1985;46:143145.
104.Wall, M, Mielke, D, Luther, JS. Panic attacks and psychomotor seizures following right temporal lobectomy [letter]. J Clin Psychiatry. 1986;47:219.
105.Ghadirian, AM, Gauthier, S, Bertrand, L. Anxiety attacks in a patient with a right temporal lobe meningioma. J Clin Psychiatry. 1986;47:270271.
106.Fontaine, R, Breton, G, Dery, R, et al.Temporal lobe abnormalities in panic disorder: an MRI study. Biol Psychiatry. 1990;27:304310.
107.Stewart, RS, Devous, MD, Rush, AJ, et al.Cerebral blood flow changes during sodium-lactate-induced panic attacks. Am J Psychiatry. 1988;145:442449.
108.Reiman, EM, Raichle, ME, Robins, E, et al.Neuroanatomical correlates of lactate-induced anxiety attack. Arch Gen Psychiatry. 1989;46:493500.
109.Nordahl, TE, Semple, WE, Gross, M, et al.Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology. 1990;3:261272.
110.Nordahl, TE, Stein, MB, Benkelfat, C, et al.Regional cerebral metabolic asymmetries replicated in an independent group of patients with panic disorder. Biol Psychiatry. 1998;44:9981006.
111.Galderisi, S, Bucci, P, Mucci, A, et al.Brain electrical microstates in subjects with panic disorder. Brain Res Bull. In Press.
112.Lehmann, D. Principles of spatial analysis. In: Gevins, AS, Remond, A, eds. Methods of Analysis of Brain Electrical and Magnetic Signals. Handbook of Electroencephalography and Clinical Neurophysiology. Amsterdam, The Netherlands: Elsevier; 1987:309354.
113.Koenig, T, Lehmann, D. Microstates in language-related brain potential maps show noun-verb differences. Brain Lang. 1996;53:169182.
114.Koenig, T, Kochi, K, Lehmann, D. Event-related electric microstates of the brain differ between words with visual and abstract meaning. Electroencephalogr Clin Neurophysiol. 1998;106:534546.
115.Smith, ME, Halgren, E, Sokolik, M, et al.The intracranial topography of the P3 event-related potential elicited during auditory oddball. Electroencephalogr Clin Neurophysiol. 1990;76:235248.
116.Wood, C, McCarty, G, Squires, N, et al.Anatomical and physiological substrates of event-related potentials. Brain Inform. 1984;425:681721.
117.Halgren, E, Marinkovic, K, Chauvel, P. Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalogr Clin Neurophysiol. 1998;106:156164.
118.Donchin, E, Ritter, W, McCallum, WC. Cognitive psychophysiology: the endogenous components of the ERP. In: Callaway, E, Tueting, P, Koslow, S, eds. Event-related Brain Potentials in Man. New York, NY: Academic Press; 1978:349442.
119.Pritchard, WS. Psychophysiology of P300. Psychol Bull. 1981;89:506540.
120.Halgren, E. The P3: a view from the brain. Behav Brain Sci. 1988;113:381383.
121.Molnar, M, Skinner, JE, Csépe, V, et al.Correlation dimension changes accompanying the occurrence of the mismatch negativity and the P3 event related potential component. Electroencephalogr Clin Neurophysiol. 1995;95:118126.
122.Garcìa-Larrea, L, Cezanne-Bert, G. P3, Positive slow wave and working memory load: a study on the functional correlates of slow wave activity. Electroencephalogr Clin Neurophysiol. 1998;108:260273.
123.Barlow, DH. Behavioral conception and treatment of panic. Psychopharmacol Bull. 1986;22:802806.
124.Clark, DMA. Cognitive approach to panic. Behav Res Ther. 1986;24:461470.
125.Harvey, JM, Richards, JC, Dziadosz, T. Misinterpretation of ambiguous stimuli in panic disorder. Cog Ther Res. 1993;17:235248.
126.Margraf, J, Ehlers, A, Roth, WT. Biological models of panic disorder and agoraphobia—a review. Behav Res Ther. 1986;24:553567.
127.McNally, RJ, Foa, EB. Cognition and agoraphobia: bias in the interpretation of threat. Cog Ther Res. 1987;11:567581.
128.Zeitlin, SB, McNally, RJ. Alexithymia and anxiety sensitivity in panic disorder and obsessive-compulsive disorder. Am J Psychiatry. 1993;150:658660.
129.Cox, CL, Fedio, P, Rapoport, JL. Neuropsychological testing of obsessive adolescents. In: Rapoport, JL, ed. Obsessive-Compulsive Disorder in Children and Adolescents. Washington, DC: American Psychiatric Press; 1989:7385.
130.Boone, KB, Ananth, J, Philpott, L, et al.Neuropsychological characteristics of nondepressed adults with obsessive-compulsive disorder. Neuropsychiatry, Neuropsychol, Behav Neurol. 1991;4:96109.
131.Zielinski, CM, Taylor, MA, Juzwin, KR. Neuropsychological deficits in obsessive-compulsive disorder. Neuropsychiatry, Neuropsychol, Behav Neurol. 1991;4:110126.
132.Christensen, KJ, Kim, SW, Dysken, MW, et al.Neuropsychological performance in obsessive-compulsive disorder. Biol Psychiatry. 1992;31:418.
133.Dirson, S, Bouvard, M, Cottraux, J, et al.Visual memory impairment in patients with obsessive-compulsive disorder: a controlled study. Psychother Psychosom. 1995;63:2231.
134.Flor-Henry, P, Yeudall, LT, Koles, ZJ, et al.Neuropsychological and power spectral EEG investigations of the obsessive-compulsive syndrome. Biol Psychiatry. 1979;14:119130.
135.Insel, TR, Donnelly, EF, Lalakea, ML, et al.Neurological and neuropsychological studies of patients with obsessive-compulsive disorder. Biol Psychiatry. 1983;18:741751.
136.Garber, HJ, Ananth, JV, Chiu, LC, et al.Nuclear magnetic resonance study of obsessive compulsive disorder. Am J Psychiatry. 1989;146:10011005.
137.Kuskowski, MA, Malone, SM, Kim, SW, et al.Quantitative EEG in obsessive-compulsive disorder. Biol Psychiatry. 1993;33:423430.
138.Baxter, LR, Phelps, ME, Mazziotta, JC, et al.Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Arch Gen Psychiatry. 1987;44:211218.
139.Swedo, SE, Schapiro, MB, Grady, CL, et al.Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry. 1989;46:518523.
140.Guidano, VF. The Self in Process. New York, NY: Guilford Press; 1991.
141.Reed, GF. Some formal qualities of obsessional thinking. Psychiatr Clin. 1968;1:382392.
142.Persons, J, Foa, E. Processing of fearful and neutral information by obsessive compulsives. Behav Res Ther. 1984;22:259265.
143.Rapoport, J, Elkins, R, Langer, DH, et al.Childhood obsessive-compulsive disorder. Am J Psychiatry. 1981;138:15451554.
144.Ludlow, CL, Bassaich, CJ, Connor, NP, et al.Psycholinguistic testing in obsessive compulsive adolescents. In: Rapoport, JL, ed. Obsessive-Compulsive Disorder in Children and Adolescents. Washington, DC: American Psychiatric Association; 1989:87106.
145.Wexler, BE, Goodman, WK. Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder. Biol Psychiatry. 1991;29:900908.
146.Galderisi, S, Mucci, A, Catapano, F, et al.Neuropsychological slowness in obsessive compulsive patients: is it confined to tests involving the fronto-sub-cortical system? Br J Psychiatry. 1995;167:394398.
147.Veale, DM, Sahakian, BJ, Owen, AM, et al.Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder. Psychol Med. 1996;26:12611269.
148.Reed, GF. Obsessional Experience and Compulsive Behaviour. A Cognitive-Structural Approach. London, England: Academic Press Inc; 1985.
149.Salkovskis, P. Frontiers of Cognitive Therapy: The State of the Art and Beyond. New York, NY: Guilford Press; 1996.
150.Rubin, KH, Rose-Krasnor, L. Social-cognitive and social behavioral perspectives on problem solving. In: Perlmutter, M, ed. Cognitive Perspectives on Children's Social and Behavioral Development: Minnesota Symposium on Child Psychology. Vol 18. Hillsdale, NJ: Erlbaum; 1986.
151.Mischel, HN, Mischel, W. The development of children's knowledge of self-control strategies. Child Dev. 1983;54:603619.


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