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Risk of parental psychiatric disorders among adolescents with major depressive disorder according to response to antidepressant treatment: does the type of antidepressant matter?

Published online by Cambridge University Press:  06 January 2023

Shih-Jen Tsai ,
Ju-Wei Hsu ,
Kai-Lin Huang ,
Ya-Mei Bai ,
Tung-Ping Su ,
Tzeng-Ji Chen  and
Mu-Hong Chen Open the ORCID record for Mu-Hong Chen[Opens in a new window]
Shih-Jen Tsai*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Ju-Wei Hsu
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Kai-Lin Huang
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Ya-Mei Bai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Tung-Ping Su
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Psychiatry, General Cheng Hsin Hospital, Taipei, Taiwan
Tzeng-Ji Chen
Affiliation:
Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Family Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu, Taiwan
Mu-Hong Chen*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
*
*Authors for correspondence: Shih-Jen Tsai, MD and Mu-Hong Chen, MD, PhD Emails: tsai610913@gmail.com; kremer7119@gmail.com
*Authors for correspondence: Shih-Jen Tsai, MD and Mu-Hong Chen, MD, PhD Emails: tsai610913@gmail.com; kremer7119@gmail.com
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Abstract

Background

The genetic load for major depressive disorder (MDD) may be higher in people who develop MDD earlier in life. This study aimed to investigate whether the parents of adolescents with MDD were more likely to have MDD, bipolar disorder (BD), schizophrenic disorder (SZ), alcohol use disorder, or substance use disorder than the parents of adolescents without MDD. We also examined whether the response to antidepressant treatment predicted the likelihood of parental psychiatric disorders.

Methods

In all, 1,758 adolescents aged 12–19 years with antidepressant-resistant depression, 7,032 (1:4) age-/sex-matched adolescents with antidepressant-responsive depression and 7,032 (1:4) age-/sex-matched controls were included. Parental psychiatric disorders of individuals enrolled were assessed.

Results

The parents of the adolescents with MDD were more likely to be diagnosed with MDD, BD, SZ, alcohol use disorder, or substance use disorder than the parents of the control group. The parents of adolescents who were antidepressant resistant and the mothers of adolescents who were either treatment resistant or treatment responsive were more likely to be diagnosed with a psychiatric disorder.

Discussion

Our study demonstrated that parents of adolescents with MDD may be more likely to be diagnosed with MDD, BD, SZ, alcohol use disorder, or substance use disorder than parents of adolescents without MDD, suggesting the within-disorder transmission and cross-disorder transmission of these psychiatric disorders. Furthermore, the parent’s sex and the response to antidepressant treatment may affect the within-disorder transmission of MDD.

Keywords

Adolescentsantidepressant-resistant depressionantidepressant-responsive depressionmental disordersgenetic inheritance
Type
Original Research
Information
CNS Spectrums , First View , pp. 1 - 6
Copyright
© The Author(s), 2023. Published by Cambridge University Press

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