Hostname: page-component-546b4f848f-fhndm Total loading time: 0 Render date: 2023-05-30T22:38:51.178Z Has data issue: false Feature Flags: { "useRatesEcommerce": true } hasContentIssue false
  • English

Risk of parental psychiatric disorders among adolescents with major depressive disorder according to response to antidepressant treatment: does the type of antidepressant matter?

Published online by Cambridge University Press:  06 January 2023

Shih-Jen Tsai ,
Ju-Wei Hsu ,
Kai-Lin Huang ,
Ya-Mei Bai ,
Tung-Ping Su ,
Tzeng-Ji Chen  and
Mu-Hong Chen Open the ORCID record for Mu-Hong Chen[Opens in a new window]
Shih-Jen Tsai*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Ju-Wei Hsu
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Kai-Lin Huang
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Ya-Mei Bai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Tung-Ping Su
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Psychiatry, General Cheng Hsin Hospital, Taipei, Taiwan
Tzeng-Ji Chen
Affiliation:
Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Family Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu, Taiwan
Mu-Hong Chen*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
*
*Authors for correspondence: Shih-Jen Tsai, MD and Mu-Hong Chen, MD, PhD Emails: tsai610913@gmail.com; kremer7119@gmail.com
*Authors for correspondence: Shih-Jen Tsai, MD and Mu-Hong Chen, MD, PhD Emails: tsai610913@gmail.com; kremer7119@gmail.com
Get access Rights & Permissions[Opens in a new window]

Abstract

Background

The genetic load for major depressive disorder (MDD) may be higher in people who develop MDD earlier in life. This study aimed to investigate whether the parents of adolescents with MDD were more likely to have MDD, bipolar disorder (BD), schizophrenic disorder (SZ), alcohol use disorder, or substance use disorder than the parents of adolescents without MDD. We also examined whether the response to antidepressant treatment predicted the likelihood of parental psychiatric disorders.

Methods

In all, 1,758 adolescents aged 12–19 years with antidepressant-resistant depression, 7,032 (1:4) age-/sex-matched adolescents with antidepressant-responsive depression and 7,032 (1:4) age-/sex-matched controls were included. Parental psychiatric disorders of individuals enrolled were assessed.

Results

The parents of the adolescents with MDD were more likely to be diagnosed with MDD, BD, SZ, alcohol use disorder, or substance use disorder than the parents of the control group. The parents of adolescents who were antidepressant resistant and the mothers of adolescents who were either treatment resistant or treatment responsive were more likely to be diagnosed with a psychiatric disorder.

Discussion

Our study demonstrated that parents of adolescents with MDD may be more likely to be diagnosed with MDD, BD, SZ, alcohol use disorder, or substance use disorder than parents of adolescents without MDD, suggesting the within-disorder transmission and cross-disorder transmission of these psychiatric disorders. Furthermore, the parent’s sex and the response to antidepressant treatment may affect the within-disorder transmission of MDD.

Keywords

Adolescentsantidepressant-resistant depressionantidepressant-responsive depressionmental disordersgenetic inheritance
Type
Original Research
Information
CNS Spectrums , First View , pp. 1 - 6
Copyright
© The Author(s), 2023. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Costello, EJ, Egger, H, Angold, A. 10-year research update review: the epidemiology of child and adolescent psychiatric disorders: I. Methods and public health burden. J Am Acad Child Adolesc Psychiatry. 2005;44(10):972–986.CrossRefGoogle ScholarPubMed
Jane Costello, E, Erkanli, A, Angold, A. Is there an epidemic of child or adolescent depression? J Child Psychol Psychiatry Allied Discip. 2006;47(12):1263–1271.Google ScholarPubMed
Thapar, A, Collishaw, S, Pine, DS, Thapar, AK. Depression in adolescence. Lancet. 2012;379(9820):1056–1067.CrossRefGoogle ScholarPubMed
Siu, AL. Screening for depression in children and adolescents: U.S. preventive services task force recommendation statement. Ann Intern Med. 2016;164(5):360–366.CrossRefGoogle ScholarPubMed
Cousins, L, Goodyer, IM. Antidepressants and the adolescent brain. J Psychopharmacol. 2015;29(5):545–555.CrossRefGoogle ScholarPubMed
Teng, T, Zhang, Z, Yin, B, et al. Effect of antidepressants on functioning and quality of life outcomes in children and adolescents with major depressive disorder: a systematic review and meta-analysis. Transl Psychiatry. 2022;12(1):183.CrossRefGoogle ScholarPubMed
Zhou, X, Teng, T, Zhang, Y, et al. Comparative efficacy and acceptability of antidepressants, psychotherapies, and their combination for acute treatment of children and adolescents with depressive disorder: a systematic review and network meta-analysis. Lancet Psychiatry. 2020;7(7):581–601.CrossRefGoogle ScholarPubMed
Brent, D, Emslie, G, Clarke, G, et al. Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA. 2008;299(8):901–913.CrossRefGoogle ScholarPubMed
Curry, J, Rohde, P, Simons, A, et al. Predictors and moderators of acute outcome in the treatment for adolescents with depression study (TADS). J Am Acad Child Adolesc Psychiatry. 2006;45(12):1427–1439.CrossRefGoogle ScholarPubMed
Levinson, DF. The genetics of depression: a review. Biol Psychiatry. 2006;60(2):84–92.CrossRefGoogle ScholarPubMed
Sullivan, PF, Neale, MC, Kendler, KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry. 2000;157(10):1552–1562.CrossRefGoogle ScholarPubMed
Azorin, JM, Belzeaux, R, Fakra, E, Hantouche, EG, Adida, M. Characteristics of depressive patients according to family history of affective illness: findings from a French national cohort. J Affect Disord. 2016;198:15–22.CrossRefGoogle ScholarPubMed
Hardeveld, F, Spijker, J, De Graaf, R, et al. Recurrence of major depressive disorder across different treatment settings: results from the NESDA study. J Affect Disord. 2013;147(1–3):225–231.CrossRefGoogle Scholar
Patten, SB, Wang, JL, Williams, JV, Lavorato, DH, Khaled, SM, Bulloch, AG. Predictors of the longitudinal course of major depression in a Canadian population sample. Can J Psychiatry. 2010;55(10):669–676.CrossRefGoogle Scholar
Liang, CS, Bai, YM, Hsu, JW, et al. Associations of parental mental disorders and age with childhood mental disorders: a population-based cohort study with four million offspring. Eur Child Adolesc Psychiatry. 2021 Nov 21. doi: 10.1007/s00787-021-01914-3.CrossRefGoogle ScholarPubMed
Chen, MH, Hsu, JW, Huang, KL, et al. Risk and coaggregation of major psychiatric disorders among first-degree relatives of patients with bipolar disorder: a nationwide population-based study. Psychol Med. 2019;49(14):2397–2404.CrossRefGoogle ScholarPubMed
Cheng, CM, Chang, WH, Chen, MH, et al. Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study. Mol Psychiatry. 2018;23(8):1756–1763.CrossRefGoogle ScholarPubMed
Wang, HE, Cheng, CM, Bai, YM, et al. Familial coaggregation of major psychiatric disorders in first-degree relatives of individuals with autism spectrum disorder: a nationwide population-based study. Psychol Med. 2022;52(8):1437–1447.CrossRefGoogle ScholarPubMed
Chen, LC, Chen, YH, Bai, YM, Chen, TJ, Chen, MH, Su, TP. Antidepressant resistance in adolescents with major depressive disorder: a nationwide longitudinal study. J Affect Disord. 2020;262:293–297.CrossRefGoogle ScholarPubMed
Li, CT, Bai, YM, Huang, YL, et al. Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study. Br J Psychiatry. 2012;200(1):45–51.CrossRefGoogle ScholarPubMed
Liu, CY, Hung, YT, Chuang, YL, Chen, YJ, Weng, WS, Liu, JS. Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. J Health Management (Chin). 2006;4:1–22.Google Scholar
Thorup, AAE, Laursen, TM, Munk-Olsen, T, et al. Incidence of child and adolescent mental disorders in children aged 0-17 with familial high risk for severe mental illness—a Danish register study. Schizophr Res. 2018;197:298–304.CrossRefGoogle ScholarPubMed
van Santvoort, F, Hosman, CM, Janssens, JM, van Doesum, KT, Reupert, A, van Loon, LM. The impact of various parental mental disorders on children’s diagnoses: a systematic review. Clin Child Fam Psychol Rev. 2015;18(4):281–299.CrossRefGoogle ScholarPubMed
Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell. 2019;179(7):1469–1482.e1411.CrossRefGoogle Scholar
Lieb, R, Isensee, B, Höfler, M, Pfister, H, Wittchen, HU. Parental major depression and the risk of depression and other mental disorders in offspring: a prospective-longitudinal community study. Arch Gen Psychiatry. 2002;59(4):365–374.CrossRefGoogle ScholarPubMed
Maher, BS, Marazita, ML, Zubenko, WN, Kaplan, BB, Zubenko, GS. Genetic segregation analysis of alcohol and other substance-use disorders in families with recurrent, early-onset major depression. Am J Drug Alcohol Abuse. 2002;28(4):711–731.CrossRefGoogle ScholarPubMed
Huang, CC, Luo, Q, Palaniyappan, L, et al. Transdiagnostic and illness-specific functional dysconnectivity across schizophrenia, bipolar disorder, and major depressive disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(5):542–553.Google ScholarPubMed
Luttenbacher, I, Phillips, A, Kazemi, R, et al. Transdiagnostic role of glutamate and white matter damage in neuropsychiatric disorders: a systematic review. J Psychiatr Res. 2022;147:324–348.CrossRefGoogle ScholarPubMed
Jaffe, DH, Rive, B, Denee, TR. The humanistic and economic burden of treatment-resistant depression in Europe: a cross-sectional study. BMC Psychiatry. 2019;19(1):247.CrossRefGoogle ScholarPubMed
Kendler, KS, Gatz, M, Gardner, CO, Pedersen, NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry. 2006;163(1):109–114.CrossRefGoogle ScholarPubMed
Kendler, KS, Gardner, CO, Neale, MC, Prescott, CA. Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychol Med. 2001;31(4):605–616.CrossRefGoogle ScholarPubMed
Swartz, HA, Cyranowski, JM, Cheng, Y, Amole, M. Moderators and mediators of a maternal depression treatment study: impact of maternal trauma and parenting on child outcomes. Compr Psychiatry. 2018;86:123–130.CrossRefGoogle ScholarPubMed
Oladeji, BD, Gureje, O. Parental mental disorders and suicidal behavior in the Nigerian survey of mental health and well-being. Arch Suicide Res. 2011;15(4):372–383.CrossRefGoogle ScholarPubMed
Halonen, JI, Merikukka, M, Gissler, M, et al. Pathways from parental mental disorders to offspring’s work disability due to depressive or anxiety disorders in early adulthood-The 1987 Finnish birth cohort. Depress Anxiety. 2019;36(4):305–312.CrossRefGoogle ScholarPubMed
Chen, PY, Wang, SC, Poland, RE, Lin, KM. Biological variations in depression and anxiety between east and west. CNS Neurosci Ther. 2009;15(3):283–294.CrossRefGoogle ScholarPubMed