Skip to main content Accessibility help

Wolff–Parkinson–White syndrome presenting with steroid-induced bradycardia in a patient with acute rheumatic fever

  • Ali Orgun (a1), Hazım A. Gursu (a1) and Ibrahim I. Cetin (a1)


Steroids are used in the treatment of acute rheumatic fever with moderate-to-severe carditis. Corticosteroids have several cardiovascular side affects that are more common in adults than in children. Corticosteroid-related bradycardia is a rarely seen side effect. Children with bradycardia following oral corticosteroid use are rarely reported previously. We present a child who developed bradycardia after oral corticosteroid treatment and concurrent Wolff–Parkinson–White pattern.


Corresponding author

Author for correspondence: A. H. Gursu, Associate Professor Department of Pediatric Cardiology, Ankara Child Health and Diseases, Hematology Oncology Training and Research Hospital, University of Health Sciences, 06110 Ankara, Turkey. Tel: +90 505 561 87 99; Fax: +09 312 347 23 30; E-mail:


Hide All
1. Gewitz, MH, Baltimore, RS, Tani, LY, et al. Revision of the Jones criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association. Circulation 2015; 131: 18061818.
2. Klein-Gitelman, MS, Pachman, LM. Intravenous corticosteroids: adverse reactions are more variable than expected in children. J Rheumatol 1998; 25: 19952002.
3. Taylor, MR, Gaco, D. Symptomatic sinus bradycardia after a treatment course of high-dose oral prednisone. J Emerg Med 2013; 45: e55e58.
4. Vasheghani-Farahani, A, Sahraian, MA, Darabi, L, Aghsaie, A, Minagar, A. Incidence of various cardiac arrhythmias and conduction disturbances due to high dose intravenous methylprednisolone in patients with multiple sclerosis. J Neurol Sci 2011; 309: 7578.
5. Kucukosmanoglu, O, Karabay, A, Ozbarlas, N, Noyan, A, Anarat, A. Marked bradycardia due to pulsed and oral methylprednisolone therapy in a patient with rapidly progressive glomerulonephritis. Nephron 1998; 80: 484.
6. Akikusa, JD, Feldman, BM, Gross, GJ, Silverman, ED, Schneider, R. Sinus bradycardia after intravenous pulse methylprednisolone. Pediatrics 2007; 119: e778e782.
7. Al Shibli, A, Al Attrach, I, Hamdan, MA. Bradycardia following oral corticosteroid use: case report and literature review. Arab J Nephrol Transplant 2012; 5: 4749.
8. Van der Gugten, A, Bierings, M, Frenkel, J. Glucocorticoid-associated bradycardia. J Pediatr Hematol Oncol 2008; 30: 172175.
9. Olgin, JE, Zipes, D. Specific arrhythmias: diagnosis and treatment. In Libby P,, Bonow RO, Mann DL, Zipes DP, (eds) Braunwald’s Heart Disease – A text book of Cardiovascular Medicine, 8th edn. Saunders, Philadelphia, PA, 2008: 884893.
10. Pappone, C, Santinelli, V. Electrophysiology testing and catheter ablation are helpful when evaluating asymptomatic patients with Wolff-Parkinson-White pattern: the pro perspective. Card Electrophysiol Clin 2015; 7: 371376.



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed