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Vascular endothelial growth factor and its soluble receptor in infants with congenital cardiac disease

  • Anja Pohl-Schickinger (a1), Petra Koehne (a1), Thomas Schmitz (a1), Katharina R. L. Schmitt (a2), Michael Hübler (a3), Matthias Redlin (a4), Felix Berger (a5) and Brigitte Stiller (a2) (a6)...

Abstract

Patients with cyanotic congenital cardiac disease often develop major aortopulmonary collaterals. Vascular endothelial growth factor is a key promoter of angiogenesis. Its soluble receptor-1 acts as a potent antagonist. We studied 30 infants with cyanotic congenital cardiac disease and 27 infants with acyanotic congenital cardiac disease. Central venous plasma vascular endothelial growth factor and soluble vascular endothelial growth factor receptor-1 levels were measured before, and 24 and 96 hours after surgery. There was no difference between plasma vascular endothelial growth factor levels in infants with cyanotic and those with acyanotic congenital cardiac disease. In cyanotic infants, the soluble vascular endothelial growth factor receptor-1 levels tended to be higher than in the acyanotic infants. In conclusion, there is no significant difference in the plasma levels of vascular endothelial growth factor and its soluble receptor-1 between infants with cyanotic and those with acyanotic congenital cardiac disease.

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Corresponding author

Correspondence to: Dr A. Pohl-Schickinger, Department of Neonatology, Charité University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. Tel: 0049 30 450 566 122; Fax: 0049 30 450 566 922; E-mail: anja.pohl@charite.de

References

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1. Ootaki, Y, Yamaguchi, M, Yoshimura, N, Oka, S, Yoshida, M, Hasegawa, T. Vascular endothelial growth factor in children with congenital heart disease. Ann Thorac Surg 2003; 75: 15231526.
2. Suda, K, Matsumura, M, Miyanish, S, Uehara, K, Sugita, T, Matsumoto, M. Increased vascular endothelial growth factor in patients with cyanotic congenital heart diseases may not be normalized after a Fontan type operation. Ann Thorac Surg 2004; 78: 942946; discussion 946–947.
3. Klagsbrun, M, D’Amore, PA. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev 1996; 7: 259270.
4. Kendall, RL, Thomas, KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA 1993; 90: 1070510709.
5. Shibuya, M. Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis 2006; 9: 225230; discussion 231.
6. Starnes, SL, Duncan, BW, Kneebone, JM, et al. Vascular endothelial growth factor and basic fibroblast growth factor in children with cyanotic congenital heart disease. J Thorac Cardiovasc Surg 2000; 119: 534539.
7. Himeno, W, Akagi, T, Furui, J, et al. Increased angiogenic growth factor in cyanotic congenital heart disease. Pediatr Cardiol 2003; 24: 127132.
8. Webb, NJ, Bottomley, MJ, Watson, CJ, Brenchley, PE. Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: implications for measurement of circulating VEGF levels in clinical disease. Clin Sci (Lond) 1998; 94: 395404.
9. Hormbrey, E, Gillespie, P, Turner, K, et al. A critical review of vascular endothelial growth factor (VEGF) analysis in peripheral blood: is the current literature meaningful? Clin Exp Metastasis 2002; 19: 651663.
10. Arena, E, Ferrero, S. Pitfalls in the measurement of serum VEGF in children with congenital heart disease. Ann Thorac Surg 2004; 78: 18841885.
11. Hamada, H, Ebata, R, Higashi, K, et al. Serum vascular endothelial growth factor in cyanotic congenital heart disease functionally contributes to endothelial cell kinetics in vitro. Int J Cardiol 2007; 120: 6671.

Keywords

Vascular endothelial growth factor and its soluble receptor in infants with congenital cardiac disease

  • Anja Pohl-Schickinger (a1), Petra Koehne (a1), Thomas Schmitz (a1), Katharina R. L. Schmitt (a2), Michael Hübler (a3), Matthias Redlin (a4), Felix Berger (a5) and Brigitte Stiller (a2) (a6)...

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