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The use of alteplase in a newborn with an aortic arch thrombus during extracorporeal membrane oxygenation

Published online by Cambridge University Press:  02 September 2019

Lijun Yang ,
Lifen Ye  and
Ru Lin Open the ORCID record for Ru Lin [Opens in a new window]
Lijun Yang
Affiliation:
Department of Extracorporeal Circulation and Extracorporeal Life Support, Heart Institute, Zhejiang University School of Medicine Children’s Hospital, Hangzhou, China
Lifen Ye
Affiliation:
Department of Extracorporeal Circulation and Extracorporeal Life Support, Heart Institute, Zhejiang University School of Medicine Children’s Hospital, Hangzhou, China
Ru Lin*
Affiliation:
Department of Extracorporeal Circulation and Extracorporeal Life Support, Heart Institute, Zhejiang University School of Medicine Children’s Hospital, Hangzhou, China
*
Author for correspondence: Ru Lin, Department of Extracorporeal Circulation and Extracorporeal Life Support, Heart Institute, Zhejiang University School of Medicine Children’s Hospital, 3333 Binsheng Road, Binjiang District, Hangzhou 310052, China. Tel: +86 13857148130; Fax: +86057186029132; E-mail: linru.008@zju.edu.cn
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Abstract

We report a neonatal case of the use of alteplase for the lysis of a large aortic arch thrombus formed during extracorporeal membrane oxygenation support. Alteplase (0.1–0.15 mg/kg/hour) was infused for thrombolysis, and meanwhile, unfractionated heparin was administrated at 5–10 U/kg/hour for the anticoagulation purpose. Alteplase was successfully administered to this neonate after the repair of congenital diaphragmatic hernia on extracorporeal membrane oxygenation, and the patient survived without apparent catastrophic long-term complications. It is reasonable to consider alteplase therapy during extracorporeal membrane oxygenation support in this setting.

Keywords

Alteplaseneonatalextracorporeal membrane oxygenationthrombus
Type
Brief Report
Information
Cardiology in the Young , Volume 29 , Issue 10 , October 2019 , pp. 1307 - 1309
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Copyright
© Cambridge University Press 2019 

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References

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