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Unusual cause of aborted sudden cardiac death in a teen athlete: homozygosity for the 4G allele of the plasminogen activase inhibitor type 1 gene

Published online by Cambridge University Press:  12 December 2014

Susie B. Phillips ,
Sarosh Batlivala  and
Jarrod D. Knudson
Susie B. Phillips
Affiliation:
Department of Pediatrics, Children’s Heart Center, Children’s of Mississippi, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Sarosh Batlivala
Affiliation:
Department of Pediatrics, Children’s Heart Center, Division of Cardiology, Children’s of Mississippi, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Jarrod D. Knudson*
Affiliation:
Department of Pediatrics, Children’s Heart Center, Division of Critical Care, Children’s of Mississippi, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
*
Correspondence to: Assistant Professor J. D. Knudson, MD, PhD, FAAP, FACC, Department of Pediatrics, Children’s Heart Center, Division of Critical Care, Children’s of Mississippi, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States of America. Tel: +601 815 8173; Fax: +601 984 5982; E-mail: jknudson@umc.edu; jarrodknudson@gmail.com
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Abstract

Common aetiologies of sudden cardiac death in children include coronary anomalies, channelopathies, and cardiomyopathies. Less frequently, hypercoagulable states cause sudden arrest. We report an unusual case of aborted sudden cardiac death in a teenager, ultimately found to have homozygosity for the 4G allele of the plasminogen activase inhibitor type 1 gene.

Keywords

Sudden cardiac deathplasminogen activase inhibitorcoronary ischaemia
Type
Brief Reports
Information
Cardiology in the Young , Volume 25 , Issue 7 , October 2015 , pp. 1428 - 1430
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Copyright
© Cambridge University Press 2014 

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References

1. Rubart, M, Zipes, DP. Mechanisms of sudden cardiac death. J Clin Invest 2005; 115: 2305–2315.CrossRefGoogle ScholarPubMed
2. Young, KD, Seidel, JS. Pediatric cardiopulmonary resuscitation: a collective review. Ann Emerg Med 1999; 33: 195–205.CrossRefGoogle ScholarPubMed
3. Atkins, DL, Everson-Stewart, S, Sears, GK, et al. Epidemiology and outcomes from out-of-hospital cardiac arrest in children: the resuscitation outcomes consortium epistry-cardiac arrest. Circulation 2009; 119: 1484–1491.Google Scholar
4. Daniels, LB, Gordon, JB, Burns, JC. Kawasaki disease: late cardiovascular sequelae. Curr Opin Cardiol 2012; 27: 572–577.Google Scholar
5. French, JK, Van de Water, NS, Sutton, TM, et al Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction. Am Heart J 2003; 145: 118–124.Google Scholar
6. Antman, EM, Cohen, M, Bernink, PJ, et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. J Am Med Assoc 2000; 284: 835–842.Google Scholar
7. Hoekstra, T, Geleijnse, JM, Kluft, C, Giltay, EJ, Kok, FJ, Schouten, EG. 4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly. Stroke 2003; 34: 2822–2828.CrossRefGoogle ScholarPubMed
8. Isordia-Salas, I, Leanos-Miranda, A, Sainz, IM, Reyes-Maldonado, E, Borrayo-Sanchez, G. Association of the plasminogen activator inhibitor-1 gene 4G/5G polymorphism with ST elevation acute myocardial infarction in young patients. Rev Esp Cardiol 2009; 62: 365–372.Google Scholar
9. De Lucia, V, Andreassi, MG, Sabatini, L, Ait-Ali, L, Spadoni, I, Giusti, S. Myocardial infarction and arterial thrombosis in identical newborn twins with homozygosity for the PAI-1 4G/5G polymorphism. Int J Cardiol 2009; 137: e1–e4.Google Scholar
10. Leander, K, Wiman, B, Hallqvist, J, Sten-Linder, M, de Faire, U. PAI-1 level and the PAI-1 4G/5G polymorphism in relation to risk of non-fatal myocardial infarction: results from the Stockholm Heart Epidemiology Program (SHEEP). Thromb Haemost 2003; 89: 1064–1071.Google ScholarPubMed