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The relationship between Interleukin-27 gene polymorphisms and Kawasaki disease in a population of Chinese children

  • Feifei Si (a1), Yao Wu (a2), Xianmin Wang (a1), Fang Gao (a1), Dan Yang (a3) (a4), Ruixi Liu (a2) and Qijian Yi (a2)...

Abstract

Background

Kawasaki disease is the leading cause of acquired heart disease in children from developed countries. The Interleukin-6/ Interleukin-12 cytokine family has many members, including the paradoxical anti- and pro-inflammatory Interleukin-27. Recent studies have demonstrated that Interleukin-27 plays a role in immune diseases. Given this, we sought to evaluate the association between Interleukin-27 genetic polymorphisms and Kawasaki disease in Chinese children.

Methods and results

Interleukin-27 was genotyped in 100 Kawasaki disease children and 98 healthy children (controls), resulting in the direct sequencing of eight Single-nucleotide Polymorphisms: rs17855750, rs40837, rs26528, rs428253, rs4740, rs4905, rs153109, and rs181206). There were no significant differences in Interleukin-27 genotypes between Kawasaki disease and control groups. Of the eight Single-nucleotide Polymorphisms, there was a significant increase in the risk of Kawasaki disease with coronary arterial lesions in children with the rs17855750 (T>G), rs40837 (A>G), rs4740 (G>A), rs4905 (A>G), rs153109 (T>C), and rs26528 (A>G) Single-nucleotide Polymorphisms. This was particularly true for rs17855750 (T>G), which had a greater frequency in Kawasaki disease children with coronary arterial aneurysm.

Conclusion

These findings may be used as risk factors when assessing a child’s likelihood of developing Kawasaki disease, as well as for the development of future therapeutic treatments for Kawasaki disease.

Copyright

Corresponding author

Author for correspondence: Q. Yi, Department of Cardiovascular Medicine, Children’s Hospital of Chongqing Medical University, Chongqing 400014, People’s Republic of China; Tel: +86 023 6362 4344; Fax: +86 023 6362 4344; E-mail: qjyi2003@hotmail.com

Footnotes

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Cite this article: Si F, Wu Y, Wang X, Gao F, Yang D, Liu R, Yi Q. (2018). The relationship between Interleukin-27 gene polymorphisms and Kawasaki disease in a population of Chinese children. Cardiology in the Young 28: 1123–1128. doi: 10.1017/S1047951118000914

Footnotes

References

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Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
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