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Quality of life in adolescents and young adults with CHD is not reduced: a systematic review and meta-analysis

  • Morten Schrøder (a1), Kirsten A. Boisen (a1), Jesper Reimers (a2), Grete Teilmann (a3) and Jesper Brok (a4)...



We performed a systematic review and meta-analysis of observational studies assessing quality of life in adolescents and young adults born with CHD compared with age-matched controls.


We carried out a systematic search of the literature published in Medline, Embase, PsychINFO, and the Cochrane Library’s Database (1990–2013); two authors independently extracted data from the included studies. We used the Newcastle–Ottawa scale for quality assessment of studies. A random effects meta-analysis model was used. Heterogeneity was assessed using the I2-test.


We included 18 studies with 1786 patients. The studies were of acceptable-to-good quality. The meta-analysis of six studies on quality of life showed no significant difference – mean difference: −1.31; 95% confidence intervals: −6.51 to +3.89, I2=90.9% – between adolescents and young adults with CHD and controls. Similar results were found in 10 studies not eligible for the meta-analysis. In subdomains, it seems that patients had reduced physical quality of life; however, social functioning was comparable or better compared with controls.


For the first time in a meta-analysis, we have shown that quality of life in adolescents and young adults with CHD is not reduced when compared with age-matched controls.


Corresponding author

Correspondence to: M. Schrøder, MD, Department of Pediatric and Adolescent Medicine, Center of Adolescent Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100-Denmark. Tel: +452 840 3244; Fax: +45 35454673; E-mail:


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