Donofrio, MT, Duplessis, AJ, Limperopoulos, C. Impact of congenital heart disease on fetal brain development and injury. Curr Opin Pediatr
2011; 23: 502–511.
Mahle, WT, Wernovsky, G. Neurodevelopmental outcomes in hypoplastic left heart syndrome. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu
2004; 7: 39–47.
Sarajuuri, A, Jokinen, E, Puosi, R, et al. Neurodevelopment in children with hypoplastic left heart syndrome. J Pediatr
2010; 157: 414–420; e414.
Gaynor, JW, Gerdes, M, Nord, AS, et al. Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?
2010; 140: 1230–1237.
Davidson, J, Gringras, P, Fairhurst, C, Simpson, J. Physical and neurodevelopmental outcomes in children with single-ventricle circulation. Arch Dis Child
2015; 100: 449–453.
Gaynor, JW, Stopp, C, Wypij, D, et al. Neurodevelopmental outcomes after cardiac surgery in infancy. Pediatrics
2015; 135: 816–825.
Shillingford, AJ, Ittenbach, RF, Marino, BS, et al. Aortic morphometry and microcephaly in hypoplastic left heart syndrome. Cardiol Young
2007; 17: 189–195.
Wypij, D, Newburger, JW, Rappaport, LA. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg
2003; 126: 1397–1403.
Hirsch, JC, Jacobs, ML, Andropoulos, D, et al. Protecting the infant brain during cardiac surgery: a systematic review. Ann Thorac Surg
2012; 94: 1365–1373.
von Rhein, M, Dimitropoulos, A, Valsangiacomo Buechel, ER, Landolt, MA, Latal, B. Risk factors for neurodevelopmental impairments in school-age children after cardiac surgery with full-flow cardiopulmonary bypass. J Thorac Cardiovasc Surg
2012; 144: 577–583.
Kempny, A, Dimopoulos, K, Gatzoulis, MA. Single-ventricle physiology in the UK: an ongoing challenge of growing numbers and of growing complexity of congenital heart disease. Heart
2014; 100: 1315–1316.
Ballweg, JA, Wernovsky, G, Gaynor, JW. Neurodevelopmental outcomes following congenital heart surgery. Pediatr Cardiol
2007; 28: 126–133.
Laskowitz, DT, Lynch, JR, Warner, DS. Apolipoprotein E modulates the CNS response to injury. J Neurochem
2002; 81 (Suppl 1): 31.
Forbess, JM, Visconti, KJ, Bellinger, DC, Howe, RJ. Neurodevelopmental outcomes after biventricular repair of congenital heart defects. J Thorac Cardiovasc Surg
2002; 123: 631–639.
Kucik, JE, Nembhard, WN, Donohue, P, et al. Community socioeconomic disadvantage and the survival of infants with congenital heart defects. Am J Public Health
2014; 104: e150–e157.
Miller, SP, McQuillen, PS, Hamrick, S, et al. Abnormal brain development in newborns with congenital heart disease. N Engl J Med
2007; 357: 1928–1938.
Owen, M, Shevell, M, Majnemer, A, Limperopoulos, C. Abnormal brain structure and function in newborns with complex congenital heart defects before open heart surgery: a review of the evidence. J Child Neurol
2011; 26: 743–755.
Hunter, LE, Simpson, JM. Prenatal screening for structural congenital heart disease. Nat Rev Cardiol
2014; 11: 323–334.
Rychik, J, Szwast, A, Natarajan, S, et al. Perinatal and early surgical outcome for the fetus with hypoplastic left heart syndrome: a 5-year single institutional experience. Ultrasound Obstet Gynecol
2010; 36: 465–470.
Marino, BS. New concepts in predicting, evaluating, and managing neurodevelopmental outcomes in children with congenital heart disease. Curr Opin Pediatr
2013; 25: 574–584.
Norwood, WI, Lang, P, Casteneda, AR, Campbell, DN. Experience with operations for hypoplastic left heart syndrome. J Thorac Cardiovasc Surg
1981; 82: 511–519.
Majnemer, A, Limperopoulos, C, Shevell, MI, Rohlicek, C, Rosenblatt, B, Tchervenkov, C. A new look at outcomes of infants with congenital heart disease. Pediatr Neurol
2009; 40: 197–204.
Hoffman, GM, Brosig, CL, Mussatto, KA, Tweddell, JS, Ghanayem, NS. Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome. J Thorac Cardiovasc Surg
2013; 146: 1153–1164.
Knirsch, W, Liamlahi, R, Hug, MI, et al. Mortality and neurodevelopmental outcome at 1 year of age comparing hybrid and Norwood procedures. Eur J Cardiothorac Surg
2012; 42: 33–39.
Newburger, JW, Sleeper, LA, Bellinger, DC, et al. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation
2012; 125: 2081–2091.
Limperopoulos, C, Majnemer, A, Shevell, MI, Rosenblatt, B, Rohlicek, C, Tchervenkov, C. Neurologic status of newborns with congenital heart defects before open heart surgery. Pediatrics
1999; 103: 402–408.
Limperopoulos, C, Majnemer, A, Shevell, MI, Rosenblatt, B, Rohlicek, C, Tchervenkov, C. Neurodevelopmental status of newborns and infants with congenital heart defects before and after open heart surgery. J Pediatr
2000; 137: 638–645.
Heymann, MA, Rudolph, AM. Effects of congenital heart disease on fetal and neonatal circulations. Prog Cardiovasc Dis
1972; 15: 115–143.
Rosenthal, GL. Patterns of prenatal growth among infants with cardiovascular malformations: possible fetal hemodynamic effects. Am J Epidemiol
1996; 143: 505–513.
Donofrio, MT, Massaro, AN. Impact of congenital heart disease on brain development and neurodevelopmental outcome. Int J Pediatr
2010; 2010: 359390.
Petrossian, RA, Kuehl, KS, Loffredo, CA. Relationship of birth weight with congenital cardiovascular malformations in a population-based study. Cardiol Young
2015; 25: 1086–1092.
Hinton, RB, Andelfinger, G, Sekar, P, et al. Prenatal head growth and white matter injury in hypoplastic left heart syndrome. Pediatr Res
2008; 64: 364–369.
Sakazaki, S, Masutani, S, Sugimoto, M, et al. Oxygen supply to the fetal cerebral circulation in hypoplastic left heart syndrome: a simulation study based on the theoretical models of fetal circulation. Pediatr Cardiol
2014; 36: 677–684.
Donofrio, MT, Bremer, YA, Schieken, RM, et al. Autoregulation of cerebral blood flow in fetuses with congenital heart disease: the brain sparing effect. Pediatr Cardiol
2003; 24: 436–443.
Arduini, M, Rosati, P, Caforio, L, et al. Cerebral blood flow autoregulation and congenital heart disease: possible causes of abnormal prenatal neurologic development. J Matern Fetal Neonatal Med
2011; 24: 1208–1211.
Dubiel, M, Gunnarsson, GO, Gudmundsson, S. Blood redistribution in the fetal brain during chronic hypoxia. Ultrasound Obstet Gynecol
2002; 20: 117–121.
Szwast, A, Tian, Z, McCann, M, Soffer, D, Rychik, J. Comparative analysis of cerebrovascular resistance in fetuses with single-ventricle congenital heart disease. Ultrasound Obstet Gynecol
2012; 40: 62–67.
Masoller, N, Sanz-Cortés, M, Crispi, F, et al. Mid-gestation brain Doppler and head biometry in fetuses with congenital heart disease predict abnormal brain development at birth. Ultrasound Obstet Gynecol
2016; 47: 65–73.
Yamamoto, Y, Khoo, NS, Brooks, PA, Savard, W, Hirose, A, Hornberger, LK. Severe left heart obstruction with retrograde arch flow influences fetal cerebral and placental blood flow. Ultrasound Obstet Gynecol
2013; 42: 294–299.
Williams, IA, Fifer, C, Jaeggi, E, Levine, JC, Michelfelder, EC, Szwast, AL. The association of fetal cerebrovascular resistance with early neurodevelopment in single ventricle congenital heart disease. Am Heart J
2013; 165: 544–550; e541.
Glauser, TA, Rorke, LB, Weinberg, PM, Clancy, RR. Congenital brain anomalies associated with the hypoplastic left heart syndrome. Pediatrics
1990; 85: 984–990.
Licht, DJ, Shera, DM, Clancy, RR, et al. Brain maturation is delayed in infants with complex congenital heart defects. J Thorac Cardiovasc Surg
2009; 137: 529–536; discussion 536–537.
Block, AJ, McQuillen, PS, Chau, V, et al. Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. J Thorac Cardiovasc Surg
2010; 140: 550–557.
Peyvandi, S, De Santiago, V, Chakkarapani, E, et al. Association of prenatal diagnosis of critical congenital heart disease with postnatal brain development and the risk of brain injury. JAMA Pediatr
2016; 170: e154450.
Massaro, AN. MRI for neurodevelopmental prognostication in the high-risk term infant. Semin Perinatol
2015; 39: 159–167.
Andropoulos, DB, Ahmad, HB, Haq, T, et al. The association between brain injury, perioperative anesthetic exposure, and 12-month neurodevelopmental outcomes after neonatal cardiac surgery: a retrospective cohort study. Paediatr Anaesth
2014; 24: 266–274.
Licht, DJ, Wang, J, Silvestre, DW, et al. Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects. J Thorac Cardiovasc Surg
2004; 128: 841–849.
Limperopoulos, C, Tworetzky, W, McElhinney, DB, et al. Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation
2010; 121: 26–33.
Beca, J, Gunn, JK, Coleman, L, et al. New white matter brain injury after infant heart surgery is associated with diagnostic group and the use of circulatory arrest. Circulation
2013; 127: 971–979.
von Rhein, M, Buchmann, A, Hagmann, C, et al. Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease. Brain
2014; 137 (Pt 1): 268–276.
Andropoulos, DB, Hunter, JV, Nelson, DP, et al. Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. J Thorac Cardiovasc Surg
2010; 139: 543–556.
Wernovsky, G. Current insights regarding neurological and developmental abnormalities in children and young adults with complex congenital cardiac disease. Cardiol Young
2006; 16 (Suppl 1): 92–104.
Ahmed, BI. The new 3D/4D based spatio-temporal imaging correlation (STIC) in fetal echocardiography: a promising tool for the future. J Matern Fetal Neonatal Med
2014; 27: 1163–1168.
Gholipour, A, Estroff, JA, Barnewolt, CE, et al. Fetal MRI: a technical update with educational aspirations. Concepts Magn Reson Part A Bridg Educ Res
2014; 43: 237–266.
Kainz, B, Malamateniou, C, Murgasova, M, et al. Motion corrected 3D reconstruction of the fetal thorax from prenatal MRI. Med Image Comput Comput Assist Interv
2014; 17 (Pt 2): 284–291.
Seed, M, van Amerom, JFP, Yoo, SJ, et al. Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson
2012; 14: 79.
Sun, L, Macgowan, CK, Sled, JG, et al. Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation
2015; 131: 1313–1323.
Rutherford, M, Ramenghi, LA, Edwards, AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic–ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol
2010; 9: 39–45.
Rutherford, M, Biarge, MM, Allsop, J, Counsell, S. MRI of perinatal brain injury. Pediatr Radiol
2010; 40: 819–833.
Porayette, P, Sun, L, Jaeggi, E, et al. MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease. J Cardiovasc Magn Reson
2015; 17 (Suppl 1): O55.
McElhinney, DB, Tworetzky, W, Lock, JE. Current status of fetal cardiac intervention. Circulation
2010; 121: 1256–1263.
Allan, LD, Huggon, IC. Counselling following a diagnosis of congenital heart disease. Prenat Diagn
2004; 24: 1136–1142.