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Leeuwenhoek’s disease: diaphragmatic flutter in a cardiac patient

  • Himabindu Samardhi (a1), Dorothy J. Radford (a1) and Kwun M. Fong (a2)


A 15-year-old girl gave a recent history of dyspnoea and “funny turns”. She had congenital aortic stenosis, previous valvotomies, a mechanical valve replacement, permanent pacemaker, atrial tachyarrhythmias, impaired ventricular function, systemic hypotension, pulmonary hypertension, and anxiety. The diagnosis of diaphragmatic flutter was delayed due to all the differential diagnoses and rarity of the condition. It was confirmed by observation, respiratory band monitoring, volume-time spirogram and fluoroscopy during an attack.


Corresponding author

Correspondence to: Dr D. J. Radford, MD, FRACP, Department of Cardiology, The Prince Charles Hospital, Rode Road, Chermside, Queensland, 4032, Australia. Tel: 61 7 3139 4000; Fax: 61 7 3139 4715; E-mail:


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1. Leeuwenhoek, A. De globulorum sanguineorum magnitudine. Philos Trans Lond 1723; 32: 341, 438.
2. Rigatto, M, De Medeiros, NP. Diaphragmatic flutter. Report of a case and review of literature. Am J Med 1962; 32: 103109.
3. Chen, R, Remtulla, H, Bolton, CF. Electrophysiological study of diaphragmatic myoclonus. Journal Neurol Neurosurgery Psychiatry 1995; 58: 480483.
4. Cvietusa, PJ, Nimmagadda, SR, Wood, R, Liu, AH. Diaphragmatic flutter presenting as inspiratory Stridor. Chest 1995; 107: 872875.
5. Jinnai, K, Takahashi, K, Shundo, F, Komine, Y, Gotoh, K, Fujita, T. Respiratory myoclonus. Report of a case with electromyographic study. Jap J Med 1986; 25: 288292.
6. Philips, JR, Eldridge, FL. Respiratory myoclonus: Leeuwenhoek’s disease. N Engl J Medicine 1973; 289: 13901395.
7. Nakajima, M, Hirayama, K, Suzuki, J, Shinotoh, H, Yamada, T. Diaphragmatic myoclonus of spinal origin. Clin Neurol (Tokyo) 1986; 26: 1318.
8. Scheifley, CH, Saslaw, MS. Diaphragmatic spasm associated with recurrent left pneumothorax. Ann Inter Med 1947; 26: 129.
9. Soderstrom, N. Clonic spasm of the diaphragm: observation in three cases with special attention to the ECG findings. Acta Med Scand 1950; 137: 2736.
10. Kondo, T, Tamaya, S, Ohta, Y, Yamabayashi, H. Dual-respiratory rhythms. A key to diagnosis of diaphragmatic flutter in patients with hyperventilation syndrome. Chest 1989; 96: 106109.


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Leeuwenhoek’s disease: diaphragmatic flutter in a cardiac patient

  • Himabindu Samardhi (a1), Dorothy J. Radford (a1) and Kwun M. Fong (a2)


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