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Effect of Hybrid stage 1 procedure on ventricular function in infants with hypoplastic left heart syndrome*

  • Daisuke Kobayashi (a1), Girija Natarajan (a2), Daniel R. Turner (a1), Thomas J. Forbes (a1), Ralph E. Delius (a3), Henry L. Walters (a3) and Sanjeev Aggarwal (a1)...

Abstract

Objective

The effect of Hybrid stage 1 palliation for hypoplastic left heart syndrome on right ventricular function is unknown. We sought to compare right ventricular function in normal neonates and those with hypoplastic left heart syndrome before Hybrid palliation and to assess the effect of Hybrid palliation on right ventricular function, using the right ventricular myocardial performance index and the ratio of systolic and diastolic durations.

Methods

We carried out a retrospective review of echocardiographic data on 23 infants with hypoplastic left heart syndrome who underwent Hybrid palliation and 35 normal controls. Data were acquired before Hybrid and after Hybrid palliation – post 1, 0–4 days; post 2, 1 week; post 3, 2–3 weeks; post 4, 1–1.5 months following Hybrid palliation.

Results

Myocardial performance index and ratio of systolic and diastolic durations were higher in the pre-Hybrid hypoplastic left heart syndrome group (n=23) – 0.47±0.16 versus 0.25±0.07, p<0.001; 1.59±0.44 versus 1.09±0.14, p<0.0001 – compared with controls (n=35). There was no significant change in the myocardial performance index at any of the post-Hybrid time points. Ratio of systolic and diastolic durations increased significantly 2 weeks after Hybrid – post 3: 2.08±0.62 and post 4: 2.21±0.45 versus pre: 1.59±0.44, p=0.043 and 0.003. There were no significant differences in parameters between sub-groups of infants who died (n=10) and survivors (n=13).

Conclusions

Right ventricular myocardial performance index and ratio of systolic and diastolic durations were significantly higher in infants with hypoplastic left heart syndrome before intervention compared with controls. The ratio of systolic and diastolic durations increased significantly 2 weeks after Hybrid palliation. Our data suggest that infants with hypoplastic left heart syndrome have right ventricular dysfunction before intervention, which worsens over 2 weeks after Hybrid palliation.

Copyright

Corresponding author

Correspondence to: S. Aggarwal, MD, Associate Professor, Carman and Ann Adams Department of Pediatrics, Division of Cardiology, Wayne State University School of Medicine, Children’s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201-2119, United States of America. Tel: +1 313 745 6105; Fax: +1 313 993 0894; E-mail: ssanjeev@dmc.org

Footnotes

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*

All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Footnotes

References

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Keywords

Effect of Hybrid stage 1 procedure on ventricular function in infants with hypoplastic left heart syndrome*

  • Daisuke Kobayashi (a1), Girija Natarajan (a2), Daniel R. Turner (a1), Thomas J. Forbes (a1), Ralph E. Delius (a3), Henry L. Walters (a3) and Sanjeev Aggarwal (a1)...

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