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Current issues and perspectives in hypoplasia of the left heart

  • David Sedmera (a1), Andrew C. Cook (a2), Girish Shirali (a3) and Tim C. McQuinn (a1) (a3)

Abstract

Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.

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Correspondence to: David Sedmera, Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, BSB 603 Charleston, SC 29425, USA. Tel: +1 843 792 6329; Fax: +1 843 792 0664; E-mail: sedmerad@musc.edu

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Current issues and perspectives in hypoplasia of the left heart

  • David Sedmera (a1), Andrew C. Cook (a2), Girish Shirali (a3) and Tim C. McQuinn (a1) (a3)

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