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Cortical hyperostosis as a side-effect of prolonged use of prostaglandins

  • Natalia Rivero Jiménez (a1), Montserrat Bret-Zurita (a2) and Luis García-Guereta Silva (a1)


Cortical hyperostosis is a very uncommon side-effect of prolonged prostaglandin therapy with distinctive radiological signs that may be accompanied by painful swelling of the limbs and responds rapidly to withdrawal of therapy.


Corresponding author

Correspondence to: N. R. Jiménez, Department of Pediatric Cardiology, La Paz Hospital, 261 Paseo de la Castellana, Madrid 28046, Spain. Tel: +61 990 5837; Fax: 91 727 70 50; E-mail:


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1. Jorgensen, HR, Svanholm, H, Host, A. Bone formation induced in an infant by systemic prostaglandin E2 administration. Acta Orthop Scand 1988; 59: 464466.



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