Skip to main content Accessibility help
×
Home

Congenital cardiovascular lesions in children with trisomy 21 at the Bustamante Hospital for Children

  • Tamra W. Tomlinson (a1), Charmaine H. Scott (a1) and Helen L. M. Trotman (a2)

Abstract

Objective

To describe the cardiac lesions seen in children with trisomy 21, the outcome of these children and rates of access to corrective surgery at the Bustamante Hospital for Children.

Methods

A 10-year retrospective review of the records of trisomy 21 patients with cardiac lesions referred to the Bustamante Hospital for Children was conducted.

Results

A total of 76 patients were enrolled in the study, 30 (40%) males and 46 (60%) females; among these 110 cardiac lesions were detected. A total of 20 (26%) patients died, 48 (63%) survived, and for 8 (11%) the status was unknown. The most common lesion was the atrioventricular septal defect, which accounted for 41 (37%) of all the lesions and occurred as a single defect in 24 (53%) patients. At presentation, 33 (46%) patients had one or more medical complication; 30 (91%) had cardiac failure, 10 (30%) had pneumonia and 5 (15%) had evidence of systemic pulmonary arterial pressures. Cardiac catheterisation was recommended for 43 (56%) patients but only 10 (23%) had the procedure done. Surgery was recommended for 60 (79%) patients; of these 6 (10%) patients had the procedure done. The median time of survival was 88 months (7.3 years). The age of presentation was not found to significantly affect outcome.

Conclusion

Trisomy 21 patients with cardiac lesions have high morbidity and mortality. This morbidity and mortality could be reduced if surgical intervention was offered routinely.

Copyright

Corresponding author

Correspondence to: Dr Helen Trotman Department of Obstetrics, Gynaecology and Child Health, University of the West Indies, Mona, St Andrew, Jamaica. Tel: 876-970-0329; Fax: 876-927-1446; E-mail: helen.trotmanedwards@uwimona.edu.jm.

References

Hide All
1. Leshin, L. The Story of Down Syndrome, 2003. Available at URL: http://www.ds-health.com (accessed February, 2005).
2. Benke, PJ, Carver, V, Donahue, R. Risk and Recurrence Risk of Down Syndrome. University of Miami school of Medicine, 1995. Available at URL: http://www.ds-health.com/benke.htm (accessed February, 2005).
3. Jones, KL (ed.). Smith’s Recognizable Patterns of Human Malformation, 5th edn, Saunders Philadelphia, Pennsylvania, 1997, pp 810.
4. Huret, JL, Sinet, PM. Trisomy 21. Atlas Genet Cytogenet Oncol Haematol August, 2000. Available at URL: http://AtlasGeneticsOncology.org/Educ/PolyTri21Eng.html (accessed February, 2005).
5. Park, MK. Pediatric Cardiology for Practitioners, 4th edn, Mosby, St. Louis, Misouri, 2002, pp 10.
6.The Heart Center Encyclopedia, Cincinatti Children’s posting. Heart Related Syndromes: Down Syndrome (Trisomy 21), 1999. Available at URL: http://www.cincinnatichildren's.org/health/heart-encyclopedia (accessed February, 2005).
7. Hayes, C, Johnson, Z, Thornton, L, et al. Ten year survival of Down syndrome births. Int J Epidemiol 1997; 26: 822829.
8. Park, SC, Matthews, RA, Zuberbuhler, JR, Rowe, RD, Neches, WH, Lennox, CC. Down syndrome with congenital heart malformation. Am J Dis Child 1977; 131: 2933.
9. Lo, NS, Leung, PM, Lau, KC, Yeung, CY. Congenital cardiovascular malformations in Chinese children with Down’s syndrome. Chin Med J (Engl) 1989; 102: 382386.
10. Grech, V, Gatt, M. Syndromes and malformations associated with congenital heart disease in a population-based study. Int J Cardiol 1999; 68: 151156.
11. Vida, VL, Barnoya, J, Larrazabal, LA, de Maria Garcia, F, Castaneda, AR. Congenital cardiac disease in children with Down’s syndrome in Guatemala. Cardiol Young 2005; 15: 286290.
12. Matthew, P, Moodie, D, Sterba, R, Murphy, D, Rosenkranz, E, Homa, A. Long term follow up of children with Down syndrome with cardiac lesions. Clin Pediatr (Phila) 1991; 30: 128.
13.Ministry of Health, Jamaica. Bustamante Hospital for Children Monthly Hospital Statistical Report 2004 (unpublished).
14. Parvathy, U, Balakrishnan, KR, Ranjith, MS, Saldanha, R, Sai, S, Vakamudi, M. Surgical experience with congenital heart disease in Down’s syndrome. Indian Heart J 2000; 52: 438441.
15. Jaiyesimi, O, Baichoo, V. Cardiovascular malformations in Omani Arab children with Down’s syndrome. Cardiol Young 2007; 17: 166171.

Keywords

Congenital cardiovascular lesions in children with trisomy 21 at the Bustamante Hospital for Children

  • Tamra W. Tomlinson (a1), Charmaine H. Scott (a1) and Helen L. M. Trotman (a2)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed